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12,753 Research products, page 1 of 1,276

  • Publications
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  • 2012-2021
  • Doctoral thesis
  • HAL-Inserm

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  • French
    Authors: 
    Troupinon, Maud;
    Publisher: HAL CCSD
    Country: France

    Aneuploidy is a hallmark of cancer cells, characterized by a chromosome’s number which is not a multiple of the haploid complement12,15. Aneuploidy is characterized by an unbalanced genomic content. Aneuploidy as a therapeutic target is promising because it is a hallmar...

  • French
    Authors: 
    Aouache, Rajaa;
    Publisher: HAL CCSD
    Country: France

    In France, 380,000 new cancer diagnoses are made each year and 60% of these cancers are treated by radiotherapy, which uses ionizing radiation to destroy tumor cells. Radiation therapy causes undesirable radiotoxic effects on healthy tissues located in the radiation fie...

  • Publication . Doctoral thesis . 2021
    French
    Authors: 
    Mercier, Julia;
    Publisher: HAL CCSD
    Country: France

    Cystic fibrosis (CF) is due to CFTR gene pathogenic variants and has no curative treatment to date. The main cause of morbidity and mortality in CF patients is respiratory failure, due to cycles of infection and inflammation responsible for progressive lung tissue degra...

  • French
    Authors: 
    Baron, Chloé;
    Publisher: HAL CCSD
    Country: France

    The transfer of a competent embryo into a uterine cavity during the implantion window is a major objective to ensure success in in vitro fertilization (IVF). My thesis work contributes to (i) the identification of new biomarkers for the evaluation of endometrial recepti...

  • English
    Authors: 
    Tselikas, Lambros;
    Publisher: HAL CCSD
    Country: France

    Local immunotherapy is a growing therapeutic strategy which requires a specific framework in order to perform effective translational research and evaluate properly the clinical outcomes. We report here the workflow and dedicated setting implemented in our institution f...

  • French
    Authors: 
    El Haddad, Chadia;
    Publisher: HAL CCSD
    Country: France

    Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and soci...

  • English
    Authors: 
    Puy, Laurent;
    Publisher: HAL CCSD
    Country: France

    Spontaneous intracerebral haemorrhage (ICH) is associated with a dramatic prognosis and remains devoid of specific treatment. Therefore, understanding the mechanisms of ICH pathology and repair is a matter of high priority. The peri-haemorrhagic zone, commonly called "p...

  • English
    Authors: 
    Tabbal, Judie;
    Publisher: HAL CCSD
    Country: France

    As a complex system, the brain flexibly processes information through dynamic reconfiguration of distributed brain regions at sub-second time scale. A major endeavor in neuroscience is to describe the spatiotemporal organization of the brain as a series of transient “fu...

  • French
    Authors: 
    Debat, Guillaume;
    Publisher: HAL CCSD
    Country: France

    Artificial intelligence covers all the techniques and theories that enable an artificial system to act in a so-called intelligent way, i.e., as a human or an animal would. This field of research has recently made significant progress which have enabled it to surpass man...

  • French
    Authors: 
    Franchineau, Guillaume;
    Publisher: HAL CCSD
    Country: France

    The monitoring of physiopathological consequences of the mechanical ventilation seems to be fundamental for the management of patients assisted with veno-venous ECMO for refractory acute respiratory distress syndrome (ARDS). Electrical impedance tomography (EIT) allows ...