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205 research outcomes, page 1 of 21
  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | INTERACT (751404), ANR | ESCRTfission (ANR-14-CE09-0003), ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Preprint . Article . Other literature type . 2021
    Open Access English
    Authors:
    Uwizeye Clarisse; Mars Brisbin Margaret; Gallet Benoit; Chevalier Fabien; LeKieffre Charlotte; Schieber L. Nicole; Falconet Denis; Wangpraseurt Daniel; Schertel Lukas; Stryhanyuk Hryhoriy; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | CORBEL (654248), EC | ChloroMito (833184)

    International audience; Endosymbioses have shaped the evolutionary trajectory of life and remain ecologically important. Investigating oceanic photosymbioses can illuminate how algal endosymbionts are energetically exploited by their heterotrophic hosts and inform on pu...

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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Begoña Alburquerque-González; Ángel Bernabé-García; Manuel Bernabé-García; Javier Ruiz-Sanz; Fernando Feliciano López-Calderón; Leonardo Gonnelli; Lucia Banci; Jorge Peña-García; Irene Luque; Francisco José Nicolás; ...
    Persistent Identifiers
    Publisher: MDPI AG
    Project: EC | CORBEL (654248)

    Fundación Seneca 20988/PI/18 20646/JLI/18

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  • publication . Preprint . Article . Other literature type . 2021
    Open Access English
    Authors:
    Jarek Juraszek; Lucy Rutten; Sven Blokland; Pascale Bouchier; Richard Voorzaat; Tina Ritschel; Mark J G Bakkers; Ludovic Renault; Johannes P. M. Langedijk;
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Eleftherios Zarkadas; Hong Zhang; Wensheng Cai; Gregory Effantin; Jonathan Perot; Jacques Neyton; Christophe Chipot; Guy Schoehn; François Dehez; Hugues Nury;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), EC | PentaBrain (637733)

    Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea ...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Lucia Gigli; Enrico Ravera; Vito Calderone; Claudio Luchinat;
    Persistent Identifiers
    Publisher: MDPI AG

    Nature has evolved several molecular machineries to promote the formation at physiological conditions of inorganic materials, which would otherwise be formed in extreme conditions. The molecular determinants of this process have been established over the last decade, id...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Lynda Djerbal; Romain R. Vivès; Chrystel Lopin-Bon; Ralf P. Richter; Jessica C. F. Kwok; Hugues Lortat-Jacob;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    ABSTRACTSemaphorin 3A (Sema3A) is a secreted protein that signals to cells through binding to neuropilin and plexin receptors and provides neurons with guidance cues key for axon pathfinding, and also controls cell migration in several other biological systems. Sema3A i...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Valia Khodr; Paul Machillot; Elisa Migliorini; J.-B. Reiser; Catherine Picart;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Bone morphogenetic proteins (BMP) are an important family of growth factors playing a role in a large number of physiological and pathological processes, including bone homeostasis, tissue regeneration and cancers. In vivo , BMPs bind successively to both BMP receptors ...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Marcel Chris Conrady; Irina Suarez; Gergö Gogl; Desiree Isabella Frecot; Anna Bonhoure; Camille Kostmann; Alexandra Cousido-Siah; Andreá Mitschler; JiaWen Lim; Murielle Masson; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | Papillomavirus E6 Structu... (2R01CA134737-06A1)

    The degradation of p53 is a hallmark of high-risk human papillomaviruses (HPVs) of the alpha genus and HPV-related carcinogenicity. The oncoprotein E6 forms a ternary complex with the E3 ubiquitin ligase E6-associated protein (E6AP) and tumor suppressor protein p53 targ...

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  • publication . Other literature type . Article . 2020
    Open Access English
    Authors:
    Anaëlle Torres; Bastien Dalzon; Véronique Collin-Faure; Hélène Diemer; Daphna Fenel; Guy Schoehn; Sarah Cianférani; Marie Carrière; Thierry Rabilloud;
    Persistent Identifiers
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: ANR | CBH-EUR-GS (ANR-17-EURE-0003), ANR | PAIPITO (ANR-16-CE34-0011), ANR | SERENADE (ANR-11-LABX-0064)

    International audience; Synthetic amorphous silica is one of the most used nanomaterials, and numerous toxicological studies have studied its effects. Most of these studies have used an acute exposure mode to investigate the effects immediately after exposure. However, ...

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205 research outcomes, page 1 of 21