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15 research outcomes, page 1 of 2
  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Lidia Ruiz; Zuzanna Kaczmarska; Tiago Gomes; Eric Aragón; Carles Torner; Regina Freier; Blazej Baginski; Pau Martin-Malpartida; Natàlia de Martin Garrido; José A. Márquez; ...
    Publisher: Elsevier BV
    Project: EC | iNEXT (653706), EC | PREBIST (754558), EC | PROBIST (754510)

    Highlights • MH1 domains of BMP-activated Smads populate a dimer-monomer equilibrium. • Swapping loop1 between BMP- and TGFβ Smads turns dimers into monomers and vice versa. • BMP-responsive genomic regions have a lower average count of motifs than TGFβ ones.

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  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Yannick Blum; Jan Mikelson; Maciej Dobrzyński; Hyunryul Ryu; Marc-Antoine Jacques; Noo Li Jeon; Mustafa Khammash; Olivier Pertz;
    Publisher: Cold Spring Harbor Laboratory
    Project: SNSF | Understanding single cell... (IZKSZ3_162195), EC | TRANSVAC2 (730964)

    Abstract Stimulation of PC‐12 cells with epidermal (EGF) versus nerve (NGF) growth factors (GFs) biases the distribution between transient and sustained single‐cell ERK activity states, and between proliferation and differentiation fates within a cell population. We rep...

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  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Benjamin G Butt; Danielle J Owen; Cy M. Jeffries; Lyudmila Ivanova; Jack W. Houghton; Firoz Ahmed; Robin Antrobus; Dmitri I. Svergun; John J. Welch; Colin M. Crump; ...
    Persistent Identifiers
    Publisher: bioRxiv
    Project: EC | BIOSTRUCT-X (283570), EC | iNEXT (653706), WT | Molecular mechanisms of m... (098406)

    AbstractHerpesviruses are an ancient family of highly-prevalent human and animal pathogens that acquire their membrane envelopes in the cytoplasm of infected cells. While multiple conserved viral proteins are known to be required for efficient herpesvirus production, ma...

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  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Iain M Hay; Gareth W. Fearnley; Pablo Rios; Maja Köhn; Hayley J. Sharpe; Janet E. Deane;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | BIOSTRUCT-X (283570), WT

    Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy re...

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  • publication . Conference object . Other literature type . Part of book or chapter of book . Preprint . 2019
    Open Access English
    Authors:
    Miriam Baglioni; Alessia Bardi; Argiro Kokogiannaki; Paolo Manghi; Katerina Iatropoulou; Pedro Príncipe; André Vieira; Lars Holm Nielsen; Harry Dimitropoulos; Ioannis Foufoulas; ...
    Publisher: Springer International Publishing, CH-6330 Cham (ZG), CHE
    Project: EC | OpenAIRE-Advance (777541), WT , EC | OpenAIRE-Connect (731011)

    First Online 30 August 2019

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Joao Ramos; Jayaraman Muthukumaran; Filipe Freire; João Paquete-Ferreira; Ana Rita Otrelo-Cardoso; Dmitri I. Svergun; Alejandro Panjkovich; Teresa Santos-Silva;
    Project: EC | iNEXT (653706)

    International journal of molecular sciences 20(4), 860 - (2019). doi:10.3390/ijms20040860

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Inês B. Trindade; José Madeira da Silva; Bruno M. Fonseca; Teresa Catarino; Masaki J. Fujita; Pedro M. Matias; Elin Moe; Ricardo O. Louro;
    Persistent Identifiers
    Project: EC | TIMB3 (810856), EC | BIOSTRUCT-X (283570), EC | IMpaCT (857203)

    This work was supported by the European Union’s Horizon 2020 research and innovation program under Grant 810856, National Funds Grant ERA-MBT/ 0003/2014, Ph.D. fellowship PD/BD/135187/2017 (to I. B. T.), and postdoctoral fellowships SFRH/BPD/94050/2013 and SFRH/BPD/9316...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Kelly Stefany Tuna Frade; Andreia Cecília Pimenta Fernandes; Célia M. Silveira; Carlos Frazão; Elin Moe;
    Persistent Identifiers
    Project: EC | BIOSTRUCT-X (283570), EC | IMpaCT (857203)

    Deinococcus radiodurans is a bacterium with extreme resistance to desiccation and radiation. The resistance mechanism is unknown, but an efficient reactive oxygen species (ROS) scavenging system and DNA-repair and DNA-protection mechanisms are believed to play importan...

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  • publication . Other literature type . Article . 2018
    Open Access English
    Authors:
    Katharina Weinhäupl; Martha Brennich; Uli Kazmaier; Joël Lelièvre; Lluis Ballell; Alfred L. Goldberg; Paul Schanda; Hugo Fraga;
    Persistent Identifiers
    Publisher: American Society for Biochemistry and Molecular Biology

    Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill Mycobacterium tuberculosis pe...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Immacolata Venditto; A.S. Luis; Maja G. Rydahl; Julia Schückel; Vânia O. Fernandes; Silvia Vidal-Melgosa; Pedro Bule; Arun Goyal; Virgínia M. R. Pires; Catarina G. Dourado; ...
    Persistent Identifiers
    Project: UKRI | RICEFUEL: Engineering enz... (BB/K020358/1), EC | BIOSTRUCT-X (283570), EC | Pectin (707922), EC | WALLTRAC (263916)

    The breakdown of plant cell wall (PCW) glycans is an important biological and industrial process. Noncatalytic carbohydrate binding modules (CBMs) fulfill a critical targeting function in PCW depolymerization. Defining the portfolio of CBMs, the CBMome, of a PCW degradi...

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15 research outcomes, page 1 of 2