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12 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Lidia Ruiz; Zuzanna Kaczmarska; Tiago Gomes; Eric Aragón; Carles Torner; Regina Freier; Blazej Baginski; Pau Martin-Malpartida; Natàlia de Martin Garrido; José A. Márquez; ...
    Publisher: bioRxiv
    Project: EC | iNEXT (653706), EC | PREBIST (754558), EC | PROBIST (754510)

    SummaryR-Smads are effectors of the transforming growth factor β (TGFβ) superfamily and along with Smad4 form trimers to interact with other transcription factors and with DNA. The 5GC-DNA complexes determined here by X-ray crystallography for Smad5 and Smad8 proteins c...

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  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Yannick Blum; Jan Mikelson; Maciej Dobrzyński; Hyunryul Ryu; Marc-Antoine Jacques; Noo Li Jeon; Mustafa Khammash; Olivier Pertz;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | TRANSVAC2 (730964), SNSF | Understanding single cell... (IZKSZ3_162195)

    Abstract Stimulation of PC‐12 cells with epidermal (EGF) versus nerve (NGF) growth factors (GFs) biases the distribution between transient and sustained single‐cell ERK activity states, and between proliferation and differentiation fates within a cell population. We rep...

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  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Benjamin G Butt; Danielle J Owen; Cy M. Jeffries; Lyudmila Ivanova; Jack W. Houghton; Firoz Ahmed; Robin Antrobus; Dmitri I. Svergun; John J. Welch; Colin M. Crump; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706), WT | Molecular mechanisms of m... (098406), EC | BIOSTRUCT-X (283570)

    AbstractHerpesviruses are an ancient family of highly-prevalent human and animal pathogens that acquire their membrane envelopes in the cytoplasm of infected cells. While multiple conserved viral proteins are known to be required for efficient herpesvirus production, ma...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Iain M Hay; Gareth W. Fearnley; Pablo Rios; Maja Köhn; Hayley J. Sharpe; Janet E. Deane;
    Publisher: Nature Publishing Group UK
    Project: WT , EC | BIOSTRUCT-X (283570)

    Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy re...

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  • publication . Preprint . Other literature type . Conference object . Part of book or chapter of book . 2019
    Open Access English
    Authors:
    Miriam Baglioni; Alessia Bardi; Argiro Kokogiannaki; Paolo Manghi; Katerina Iatropoulou; Pedro Príncipe; André Vieira; Lars Holm Nielsen; Harry Dimitropoulos; Ioannis Foufoulas; ...
    Project: EC | OpenAIRE-Connect (731011), EC | OpenAIRE-Advance (777541), WT

    First Online 30 August 2019

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Tiago N. Cordeiro; Nathalie Sibille; Pierre Germain; Philippe Barthe; Abdel Boulahtouf; Frédéric Allemand; Rémy Bailly; Valérie Vivat; Christine Ebel; Alessandro Barducci; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    AbstractThe retinoic acid receptors (RARs) form heterodimers with retinoid X receptors (RXRs) and control gene transcription in response to ligand binding and via allosteric activation of the C-termini helix (helix H12) of its ligand-binding domain. Herein we show that ...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Joao Ramos; Jayaraman Muthukumaran; Filipe Freire; João Paquete-Ferreira; Ana Rita Otrelo-Cardoso; Dmitri I. Svergun; Alejandro Panjkovich; Teresa Santos-Silva;
    Project: EC | iNEXT (653706)

    International journal of molecular sciences 20(4), 860 - (2019). doi:10.3390/ijms20040860

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Inês B. Trindade; José Madeira da Silva; Bruno M. Fonseca; Teresa Catarino; Masaki J. Fujita; Pedro M. Matias; Elin Moe; Ricardo O. Louro;
    Persistent Identifiers
    Project: EC | TIMB3 (810856), EC | IMpaCT (857203), EC | BIOSTRUCT-X (283570)

    This work was supported by the European Union’s Horizon 2020 research and innovation program under Grant 810856, National Funds Grant ERA-MBT/ 0003/2014, Ph.D. fellowship PD/BD/135187/2017 (to I. B. T.), and postdoctoral fellowships SFRH/BPD/94050/2013 and SFRH/BPD/9316...

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  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Venditto, Immacolata; Luis, Ana S.; Rydahl, Maja; Schuckel, Julia; Fernandes, Vania O.; Vidal-Melgosa, Silvia; Bule, Pedro; Goyal, Arun; Pires, Virginia M. R.; Dourado, Catarina G.; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570), UKRI | RICEFUEL: Engineering enz... (BB/K020358/1), EC | WALLTRAC (263916), EC | Pectin (707922)

    The breakdown of plant cell wall (PCW) glycans is an important biological and industrial process. Noncatalytic carbohydrate binding modules (CBMs) fulfill a critical targeting function in PCW depolymerization. Defining the portfolio of CBMs, the CBMome, of a PCW degradi...

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  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Joana A. Santos; Noelia Alonso-García; Sandra Macedo-Ribeiro; Pedro Pereira;
    Persistent Identifiers
    Publisher: National Academy of Sciences
    Project: EC | BIOSTRUCT-X (283570), FCT | PTDC/BBB-BEP/2127/2012 (127722)

    Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver them to the final acceptor molecules in a tightly regulated process. In...

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12 research outcomes, page 1 of 2