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  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Vidalis, Amaryllis; Živković, Daniel; Wardenaar, René; Roquis, David; Tellier, Aurélien; Johannes, Frank;
    Country: Netherlands

    Erratum After publication of this article [1] we noticed that the centromere of Chromosome 3 was missing from Fig. 4a, and that the Fig. 4e y-axis should read ‘CG meth. Div. W-Acc.’. The y-axis of the barplot in Fig. 5a should read ‘Number of cytosines’. The corrected Figs. 4 and 5 are shown below.

  • Open Access English
    Authors: 
    Contarino, Maria Fiorella; van den Dool, Joost; Balash, Yacov; Bhatia, Kailash; Giladi, Nir; Koelman, Johannes H.; Lokkegaard, Annemette; Marti, Maria J.; Postma, Miranda; Relja, Maja; +7 more
    Country: Netherlands

    Cervical dystonia (CD) is the most frequent form of focal dystonia. Symptoms often result in pain and functional disability. Local injections of botulinum neurotoxin are currently the treatment of choice for CD. Although this treatment has proven effective and is widely applied worldwide, many issues still remain open in the clinical practice. We performed a systematic review of the literature on botulinum toxin treatment for CD based on a question-oriented approach, with the aim to provide practical recommendations for the treating clinicians. Key questions from the clinical practice were explored. Results suggest that while the beneficial effect of botulinum toxin treatment on different aspects of CD is well established, robust evidence is still missing concerning some practical aspects, such as dose equivalence between different formulations, optimal treatment intervals, treatment approaches, and the use of supportive techniques including electromyography or ultrasounds. Established strategies to prevent or manage common side effects (including excessive muscle weakness, pain at injection site, dysphagia) and potential contraindications to this treatment (pregnancy and lactation, use of anticoagulants, neurological comorbidities) should also be further explored.

  • Open Access Dutch; Flemish
    Authors: 
    van der Lee, R; Ellemers, N.; Leerstoel Ellemers;
    Publisher: Universiteit Leiden
    Country: Netherlands
    Project: NSERC

    Vrouwen zijn nog steeds ondervertegenwoordigd in academische topposities. Een van de mogelijke verklaringen hiervoor is het toegenomen belang van het binnenhalen van onderzoeksfinanciering. Vrouwen scoren hierop vaak slechter dan mannen. Psychologisch onderzoekers dr. Romy van der Lee en prof. dr. Naomi Ellemers onderzochten of dit verschil ook bij NWO bestaat, en waar het mee te maken heeft. Uit een wetenschappelijke analyse van drie Veni-rondes blijkt dat vrouwelijke aanvragers door beoordelaars lager geprioriteerd worden.

  • Other research product . Other ORP type . 2015
    Open Access English
    Authors: 
    Vendel, Esmée;
    Country: Netherlands
  • Other research product . Other ORP type . 2013
    Open Access English
    Authors: 
    Schuurmans, J.M.; Verbree, J.M.; Leijnse, H.; van Heeringen, K.J.; Uijlenhoet, R.; Bierkens, M.F.P.; van de Giesen, N.; de Gooijer, J.; van der Houten, G.; Ecohydrology; +3 more
    Country: Netherlands
  • Other research product . Other ORP type . 2012
    Open Access English
    Authors: 
    Zhang, J.; Wilson, M.L.; Russell-Rose, T; Larsen, B; Kalbach, J;
    Country: Netherlands

    People with complex information needs are for example Humanities researchers, who need advanced search engines to investigate their research questions. Much can be gained by combining research datasets, reusing tools and serendipitously discovering new insights for further research. Humanities researchers have different (large-scale) research datasets and tools, which are described differently with metadata. We present a highly interactive advanced search engine for Humanities researchers that semantically converges differently structured metadata records from different collections and institutions. It has features that support serendipitous and focused search in context based on the structure of the metadata used. This single system serves Humanities researchers by allowing them to search interactively across yet unexplored (research) data, discover patterns, locate relevant data for new insights, and find existing tools that could provide novel use cases.

  • Open Access English
    Authors: 
    Matys Grygar, T.; Novakova, T.; Lukešová, V.; van der Perk, M.; Middelkoop, H.; Macklin, M. G.; Geomorfologie; Coastal dynamics, Fluvial systems and Global change;
    Country: Netherlands

    In our laboratory we work on the quantification of heavy metal pollution in fluvial sediments of which sedimentological description, facial assignment, post-depositional stability and dating are incomplete or missing. Without such fundamental knowledge the only robust information is apparently the absolute concentration of heavy metals. Due to local geochemical differences and heavy metal sorting by fluvial transport and pedogenesis, the actual level of anthropogenic contamination is usually considered inconclusive when the enrichment factor EF

  • Open Access English
    Authors: 
    Komenda, J.; Masopust, Tomas; Schuppen, Jan;
    Publisher: Cornell University Library
    Country: Netherlands
    Project: EC | DISC (224498)

    Supervisory control of discrete-event systems with a global safety specification and with only local supervisors is a diffcult problem. For global specifications the equivalent conditions for local control synthesis to equal global control synthesis may not be met. This paper formulates and solves a control synthesis problem for a generator with a global specifcation and with a combination of a coordinator and local controllers. Conditional controllability is proven to be an equivalent condition for the existence of such a coordinated controller. A procedure to compute the least restrictive solution is also provided in this paper and conditions are stated under which the result of our procedure coincides with the supremal controllable sublanguage.

  • Other research product . Other ORP type . 2010
    Open Access English
    Authors: 
    Sanderse, Benjamin; Pijl, Sander; Koren, Barry;
    Publisher: CWI
    Country: Netherlands

    This article reviews the state of the art of the numerical calculation of wind-turbine wake aerodynamics. Different CFD techniques for modeling the rotor and the wake are discussed. Regarding rotor modeling, recent advances in the generalized actuator approach and the direct model are discussed, as far as it attributes to the wake description. For the wake, the focus is on the different turbulence models that are employed to study wake effects on downstream turbines.

  • Other research product . Other ORP type . 2009
    Open Access Dutch; Flemish
    Authors: 
    Verhulst, Ferdinand; Analysis; Sub Mathematical Modeling;
    Country: Netherlands
Advanced search in
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
12 Research products, page 1 of 2
  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Vidalis, Amaryllis; Živković, Daniel; Wardenaar, René; Roquis, David; Tellier, Aurélien; Johannes, Frank;
    Country: Netherlands

    Erratum After publication of this article [1] we noticed that the centromere of Chromosome 3 was missing from Fig. 4a, and that the Fig. 4e y-axis should read ‘CG meth. Div. W-Acc.’. The y-axis of the barplot in Fig. 5a should read ‘Number of cytosines’. The corrected Figs. 4 and 5 are shown below.

  • Open Access English
    Authors: 
    Contarino, Maria Fiorella; van den Dool, Joost; Balash, Yacov; Bhatia, Kailash; Giladi, Nir; Koelman, Johannes H.; Lokkegaard, Annemette; Marti, Maria J.; Postma, Miranda; Relja, Maja; +7 more
    Country: Netherlands

    Cervical dystonia (CD) is the most frequent form of focal dystonia. Symptoms often result in pain and functional disability. Local injections of botulinum neurotoxin are currently the treatment of choice for CD. Although this treatment has proven effective and is widely applied worldwide, many issues still remain open in the clinical practice. We performed a systematic review of the literature on botulinum toxin treatment for CD based on a question-oriented approach, with the aim to provide practical recommendations for the treating clinicians. Key questions from the clinical practice were explored. Results suggest that while the beneficial effect of botulinum toxin treatment on different aspects of CD is well established, robust evidence is still missing concerning some practical aspects, such as dose equivalence between different formulations, optimal treatment intervals, treatment approaches, and the use of supportive techniques including electromyography or ultrasounds. Established strategies to prevent or manage common side effects (including excessive muscle weakness, pain at injection site, dysphagia) and potential contraindications to this treatment (pregnancy and lactation, use of anticoagulants, neurological comorbidities) should also be further explored.

  • Open Access Dutch; Flemish
    Authors: 
    van der Lee, R; Ellemers, N.; Leerstoel Ellemers;
    Publisher: Universiteit Leiden
    Country: Netherlands
    Project: NSERC

    Vrouwen zijn nog steeds ondervertegenwoordigd in academische topposities. Een van de mogelijke verklaringen hiervoor is het toegenomen belang van het binnenhalen van onderzoeksfinanciering. Vrouwen scoren hierop vaak slechter dan mannen. Psychologisch onderzoekers dr. Romy van der Lee en prof. dr. Naomi Ellemers onderzochten of dit verschil ook bij NWO bestaat, en waar het mee te maken heeft. Uit een wetenschappelijke analyse van drie Veni-rondes blijkt dat vrouwelijke aanvragers door beoordelaars lager geprioriteerd worden.

  • Other research product . Other ORP type . 2015
    Open Access English
    Authors: 
    Vendel, Esmée;
    Country: Netherlands
  • Other research product . Other ORP type . 2013
    Open Access English
    Authors: 
    Schuurmans, J.M.; Verbree, J.M.; Leijnse, H.; van Heeringen, K.J.; Uijlenhoet, R.; Bierkens, M.F.P.; van de Giesen, N.; de Gooijer, J.; van der Houten, G.; Ecohydrology; +3 more
    Country: Netherlands
  • Other research product . Other ORP type . 2012
    Open Access English
    Authors: 
    Zhang, J.; Wilson, M.L.; Russell-Rose, T; Larsen, B; Kalbach, J;
    Country: Netherlands

    People with complex information needs are for example Humanities researchers, who need advanced search engines to investigate their research questions. Much can be gained by combining research datasets, reusing tools and serendipitously discovering new insights for further research. Humanities researchers have different (large-scale) research datasets and tools, which are described differently with metadata. We present a highly interactive advanced search engine for Humanities researchers that semantically converges differently structured metadata records from different collections and institutions. It has features that support serendipitous and focused search in context based on the structure of the metadata used. This single system serves Humanities researchers by allowing them to search interactively across yet unexplored (research) data, discover patterns, locate relevant data for new insights, and find existing tools that could provide novel use cases.

  • Open Access English
    Authors: 
    Matys Grygar, T.; Novakova, T.; Lukešová, V.; van der Perk, M.; Middelkoop, H.; Macklin, M. G.; Geomorfologie; Coastal dynamics, Fluvial systems and Global change;
    Country: Netherlands

    In our laboratory we work on the quantification of heavy metal pollution in fluvial sediments of which sedimentological description, facial assignment, post-depositional stability and dating are incomplete or missing. Without such fundamental knowledge the only robust information is apparently the absolute concentration of heavy metals. Due to local geochemical differences and heavy metal sorting by fluvial transport and pedogenesis, the actual level of anthropogenic contamination is usually considered inconclusive when the enrichment factor EF

  • Open Access English
    Authors: 
    Komenda, J.; Masopust, Tomas; Schuppen, Jan;
    Publisher: Cornell University Library
    Country: Netherlands
    Project: EC | DISC (224498)

    Supervisory control of discrete-event systems with a global safety specification and with only local supervisors is a diffcult problem. For global specifications the equivalent conditions for local control synthesis to equal global control synthesis may not be met. This paper formulates and solves a control synthesis problem for a generator with a global specifcation and with a combination of a coordinator and local controllers. Conditional controllability is proven to be an equivalent condition for the existence of such a coordinated controller. A procedure to compute the least restrictive solution is also provided in this paper and conditions are stated under which the result of our procedure coincides with the supremal controllable sublanguage.

  • Other research product . Other ORP type . 2010
    Open Access English
    Authors: 
    Sanderse, Benjamin; Pijl, Sander; Koren, Barry;
    Publisher: CWI
    Country: Netherlands

    This article reviews the state of the art of the numerical calculation of wind-turbine wake aerodynamics. Different CFD techniques for modeling the rotor and the wake are discussed. Regarding rotor modeling, recent advances in the generalized actuator approach and the direct model are discussed, as far as it attributes to the wake description. For the wake, the focus is on the different turbulence models that are employed to study wake effects on downstream turbines.

  • Other research product . Other ORP type . 2009
    Open Access Dutch; Flemish
    Authors: 
    Verhulst, Ferdinand; Analysis; Sub Mathematical Modeling;
    Country: Netherlands
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