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  • Open Access English
    Authors: 
    Erika Cecon; Julie Dam; Ralf Jockers;
    Publisher: HAL CCSD
    Country: France

    The SARS-CoV-2 coronavirus infects human cells through the interaction of the viral envelope Spike protein (IPR044366) with the human Angiotensin-Converting Enzyme 2 (ACE2), expressed at the surface of target cells. Here, we describe a detailed protocol to measure the b...

  • Open Access English
    Authors: 
    Mehdi Stiti; Guillaume Castanet; Andrew Corber; Marcus Aldén; Edouard Berrocal;
    Publisher: HAL CCSD
    Country: France
    Project: EC | Spray-Imaging (638546)

    To control the evolution of a pandemic such as COVID-19, knowing the conditions under which the pathogen is being transmitted represents a critical issue, especially when implementing protection strategies like social distancing and face masks wearing. For viruses and b...

  • Open Access English
    Authors: 
    Thomas Meunier; Lowiese Desmarets; Simon Bordage; Moussa Bamba; Kévin Hervouet; Yves Rouillé; Nathan François; Marion Decossas; Valentin Sencio; François Trottein; +6 more
    Publisher: HAL CCSD
    Country: France

    International audience; The SARS-CoV-2 outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against HCoV-229E after bioguided fractionation of plant ...

  • Open Access English
    Authors: 
    Jean-Pierre Alcaraz; Laurence Le Coq; Jérémie Pourchez; Dominique Thomas; Sandrine Chazelet; Isabelle Boudry; Maud Barbado; Sophie Silvent; Claire Dessale; Fabienne Antoine; +25 more
    Publisher: Elsevier
    Country: France

    The need for personal protective equipment increased exponentially in response to the Covid-19 pandemic. To cope with the mask shortage during springtime 2020, a French consortium was created to find ways to reuse medical and respiratory masks in healthcare departments....

  • Open Access English
    Authors: 
    Darielys Santana-Mederos; Rocmira Perez-Nicado; Yanet Climent; Laura Rodriguez; Belinda Sanchez Ramirez; Sonia Perez-Rodriguez; Meybi Rodriguez; Claudia Labrada; Tays Hernandez; Marianniz Diaz; +36 more
    Publisher: HAL CCSD
    Countries: France, Netherlands

    SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host's cellular receptor. Vaccines seek to block this interaction by eliciting neutralizing antibodies, most of which are directed toward ...

  • Open Access English
    Authors: 
    Brice Autier; Juergen Prattes; P. Lewis White; Maricela Valerio; Marina Machado; Jessica S Price; Matthias Egger; Jean-Pierre Gangneux; Martin Hoenigl;
    Publisher: HAL CCSD
    Countries: France, France, United States, France

    International audience; This multicenter study evaluated the IMMY Aspergillus Galactomannan Lateral Flow Assay (LFA) with automated reader for diagnosis of pulmonary aspergillosis in patients with COVID-19 associated acute respiratory failure (ARF) requiring intensive c...

  • Open Access English
    Authors: 
    Hayley MacGregor; Melissa Leach; Grace Akello; Lawrence Sao Babawo; Moses Baluku; Alice Desclaux; Catherine Grant; Foday Kamara; Fred Martineau; Esther Yei Mokuwa; +5 more
    Publisher: HAL CCSD
    Country: France
    Project: WT

    International audience; This article shares findings on COVID-19 in Africa across 2020 to examine concepts and practices of epidemic preparedness and response. Amidst uncertainties about the trajectory of COVID-19, the stages of emergency response emerge in practice as ...

  • Open Access English
    Authors: 
    Bosetti, Paolo; Tran Kiem, Cécile; Andronico, Alessio; Paireau, Juliette; Levy-Bruhl, Daniel; Alter, Lise; Fontanet, Arnaud; Cauchemez, Simon;
    Publisher: HAL CCSD
    Country: France

    Europe has experienced a large COVID-19 wave caused by the Delta variant in winter 2021/22. Using mathematical models applied to Metropolitan France, we find that boosters administered to ≥ 65, ≥ 50 or ≥ 18 year-olds may reduce the hospitalisation peak by 25%, 36% and 4...

  • Open Access English
    Authors: 
    Rachida Boukhari; Adrien Breiman; Adrien Breiman; Jennifer Jazat; Nathalie Ruvoën-Clouet; Nathalie Ruvoën-Clouet; Salima Martinez; Anne Damais-Cepitelli; Catherine Le Niger; Isabelle Devie-Hubert; +6 more
    Publisher: Frontiers Media S.A.
    Country: France

    International audience; ABO blood groups appear to be associated with the risk of SARS-CoV-2 infection, but the underlying mechanisms and their real importance remain unclear. Two hypotheses have been proposed: ABO compatibility-dependence (neutralization by anti-ABO an...

  • Open Access English
    Authors: 
    Ruppert Vimal;
    Publisher: Elsevier B.V.
    Country: France

    International audience; The Covid-19 pandemic has resulted in extensive lockdowns implemented all around the world and billion of people have been asked to stay at home for several weeks. Although this global confinement has had potentially huge unintended consequences ...