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376 research outcomes, page 1 of 38
  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Laura Di Domenico; Giulia Pullano; Chiara E. Sabbatini; Pierre-Yves Boëlle; Vittoria Colizza;
    Publisher: Nature Publishing Group UK
    Project: ANR | DataRedux (ANR-19-CE46-0008), EC | MOOD (874850), ANR | SPHINx (ANR-17-CE36-0008)

    As countries in Europe implement strategies to control the COVID-19 pandemic, different options are chosen regarding schools. Through a stochastic age-structured transmission model calibrated to the observed epidemic in Île-de-France in the first wave, we explored scena...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Daniel Sanchez-Guzman; Sonja Boland; Oliver Brookes; Claire Mc Cord; René Lai Kuen; Valentina Sirri; Armelle Baeza Squiban; Stéphanie Devineau;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIORIMA (760928)

    AbstractThe human bronchial epithelium is the first line of defense against atmospheric particles, pollutants, and respiratory pathogens such as the novel SARS-CoV-2. The epithelial cells form a tight barrier and secrete proteins that are major components of the mucosal...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Samuele Bovo; Giuseppina Schiavo; Anisa Ribani; Valerio Joe Utzeri; Valeria Taurisano; Mohamad Ballan; María Muñoz; Estefania Alves; J. P. Araujo; Riccardo Bozzi; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | TREASURE (634476)

    AbstractCoronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that c...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Benjamin Gaborit; Bernard Vanhove; Marie-Anne Vibet; Aurélie Le Thuaut; Karine Lacombe; Vincent Dubee; Florence Ader; Virginie Ferre; Eric Vicaut; Jéremie Orain; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BRIGHT (962036)

    Abstract Background Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing immediate immunity, co...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Peter Czuppon; François Blanquart; Florence Débarre;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PolyPath (844369), ANR | TheoGeneDrive (ANR-19-CE45-0009)

    Emerging epidemics and local infection clusters are initially prone to stochastic effects that can substantially impact the epidemic trajectory. While numerous studies are devoted to the deterministic regime of an established epidemic, mathematical descriptions of the i...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Min‐Wen Ku; Pierre Authié; Maryline Bourgine; François Anna; Amandine Noirat; Fanny Moncoq; Benjamin Vesin; Fabien Nevo; Jodie Lopez; Philippe Souque; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PASTEURDOC (665807)

    International audience; COVID-19 vaccines already in use or in clinical development may have reduced efficacy against emerging SARS-CoV-2 variants. In addition, although the neurotropism of SARS-CoV-2 is well established, the vaccine strategies currently developed have ...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Christoph Kessel; Richard Vollenberg; Katja Masjosthusmann; Claas Hinze; Helmut Wittkowski; France Debaugnies; Carole Nagant; Francis Corazza; Frédéric Vély; Gilles Kaplanski; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | ImmunAID (779295)

    Abstract Objectives Infection with the novel coronavirus SARS‐CoV‐2 triggers severe illness with high mortality in a subgroup of patients. Such critical course of coronavirus disease (COVID)‐19 is thought to associate with cytokine storm as in macrophage activation synd...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Ostaszewski, Marek; Niarakis, Anna; Mazein, Alexander; Kuperstein, Inna; Phair, Robert; Orta-Resendiz, Aurelio; Singh, Vidisha; Aghamiri, Sara,; Acencio, Marcio,; Glaab, Enrico; ...
    Publisher: HAL CCSD
    Project: EC | INFORE (825070), EC | iPLACENTA (765274), EC | PerMedCoE (951773)

    We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort t...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Dénes Berta; Magd Badaoui; Sam Alexander Martino; Pedro J. Buigues; Andrei V. Pisliakov; Nadia Elghobashi-Meinhardt; Geoff Wells; Sarah A. Harris; Elisa Frezza; Edina Rosta;
    Persistent Identifiers
    Publisher: The Royal Society of Chemistry
    Project: EC | BioNet (757850)

    The RNA helicase (non-structural protein 13, NSP13) of SARS-CoV-2 is essential for viral replication, and it is highly conserved among the coronaviridae family, thus a prominent drug target to treat COVID-19. We present here structural models and dynamics of the helicas...

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  • publication . Article . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Josquin Daron; Ignacio G. Bravo;
    Publisher: MDPI AG
    Project: EC | CODOVIREVOL (647916), EC | METHYVIREVOL (800489)

    AbstractThe Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus within the Orthocoronavirinae causing an emergent infectious disease in humans, the ongoing coronavirus disease 2019 pandemic (COVID-19). Due to the high zoonotic potential of th...

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376 research outcomes, page 1 of 38