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  • Publication . Doctoral thesis . 2021
    French
    Authors: 
    Bernard, Sarah;
    Publisher: HAL CCSD
    Country: France

    French Polynesia has always been a space of mobility. Circulation is even consubstantial with the Polynesian identity based on a reticular territoriality. For several decades, French Polynesia as a whole has experienced a positive migratory balance, but it is mainly the...

  • French
    Authors: 
    Troupinon, Maud;
    Publisher: HAL CCSD
    Country: France

    Aneuploidy is a hallmark of cancer cells, characterized by a chromosome’s number which is not a multiple of the haploid complement12,15. Aneuploidy is characterized by an unbalanced genomic content. Aneuploidy as a therapeutic target is promising because it is a hallmar...

  • French
    Authors: 
    Aouache, Rajaa;
    Publisher: HAL CCSD
    Country: France

    In France, 380,000 new cancer diagnoses are made each year and 60% of these cancers are treated by radiotherapy, which uses ionizing radiation to destroy tumor cells. Radiation therapy causes undesirable radiotoxic effects on healthy tissues located in the radiation fie...

  • French
    Authors: 
    Crouzier-Roland, Nathalie;
    Publisher: HAL CCSD
    Country: France

    During the 13th to 15th centuries, the main towns of Aquitaine under English rule and located in Bordelais (Blaye, Bordeaux, Bourg, Cadillac, Libourne, Saint-Émilion, Saint-Macaire), developed, as part of the boom in writing and preservation of archives, many and varied...

  • French
    Authors: 
    d'Almeida, Benoît;
    Publisher: HAL CCSD
    Country: France

    When Ebenezer Howard imagines his Garden City, he is looking for a response to what his contemporaries in the second half of the 19th century considered an “urban crises without precedence”. The big cities are overpopulated and force the working classes to live un disas...

  • French
    Authors: 
    Pallares Lupon, Néstor;
    Publisher: HAL CCSD
    Country: France

    Sudden cardiac death is responsible for 50000 deaths every year in France. A loss of the electrical control of the heart, known as ventricular fibrillation leads to an inability of the heart to pump blood. Between 5 and 10 % of patients do not show any apparent electric...

  • Publication . Doctoral thesis . 2021
    French
    Authors: 
    Guyon, Joris;
    Publisher: HAL CCSD
    Country: France

    Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. It can be recognized by its angiogenic and invasive growth, in addition to its altered metabolism.To study GBM, we developed three-dimensional models to better mimic its complex architect...

  • French
    Authors: 
    Varangot, Alexandre;
    Publisher: HAL CCSD
    Country: France

    The discovery of the neuronal expression of the serine protease tissue type plasminogen activator (tPA) has opened new avenues of research, with important functions of tPA in the physiopathology of the central nervous system. For example, its interactions with synaptic ...

  • French
    Authors: 
    Buch, Chloé;
    Publisher: HAL CCSD
    Country: France

    Obesity is a pathology characterized by an excess of adipose tissue (AT) whose functions may be altered. Interestingly, strong evidence suggests that metabolic dysregulations linked to obesity is associated with an hyperactivation of the endocannabinoid system (ECS) in ...

  • Publication . Doctoral thesis . 2021
    French
    Authors: 
    Mercier, Julia;
    Publisher: HAL CCSD
    Country: France

    Cystic fibrosis (CF) is due to CFTR gene pathogenic variants and has no curative treatment to date. The main cause of morbidity and mortality in CF patients is respiratory failure, due to cycles of infection and inflammation responsible for progressive lung tissue degra...