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International audience; The SARS-CoV-2 pandemic has led to the implementation of unprecedented public health intervention measures, not least the lockdown of countries worldwide. In our hyperconnected world exemplified by social media, it is now possible to derive quant...

Nowadays, supply chain disruptions caused by COVID-19 pandemic, demand variation, raw material shortage, etc., made the supply chains unable to deal with emerging market problems. Responding to the new requirements has underscored the need to ensure a reconfigurable sup...

International audience; Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine response...

Background Patients hospitalized for a given condition may be receiving other treatments for other contemporary conditions or comorbidities. The use of such observational clinical data for pharmacological hypothesis generation is appealing in the context of an emerging...

<p style='text-indent:20px;'>In this paper, we investigate the well-posedness and dynamics of a class of hybrid models, obtained by coupling a system of ordinary differential equations and an agent-based model. These hybrid models intend to integrate the microscop...

<p style='text-indent:20px;'>During the Covid-19 pandemic a key role is played by vaccination to combat the virus. There are many possible policies for prioritizing vaccines, and different criteria for optimization: minimize death, time to herd immunity, functioni...

Health informatics and technological advances have the potential to improve the monitoring of medical and social protection of patients with communicable and non-communicable diseases through a disease management program and to reduce the financial burden on healthcare....

To control the evolution of a pandemic such as COVID-19, knowing the conditions under which the pathogen is being transmitted represents a critical issue, especially when implementing protection strategies like social distancing and face masks wearing. For viruses and b...

AbstractThe present chapter concerns arguments whose conclusions take the form of a prescription such as you ought to do such-and-such, which have driven much public discussion and policy since the beginning of the COVID-19 pandemic. We aim to tackle a hitherto under-ex...

In this paper, we develop an approach of global sensitivity analysis for compartmental models based on continuous-time Markov chains. We propose to measure the sensitivity of quantities of interest by representing the Markov chain as a deterministic function of the unce...