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43 research outcomes, page 1 of 5
  • other research product . Collection . Other ORP type . 2020
    Open Access
    Authors:
    Lähnemann, David; Köster, Johannes; Szczurek, Ewa; McCarthy, Davis J; Hicks, Stephanie C; Robinson, Mark D; Vallejos, Catalina A; Campbell, Kieran R; Beerenwinkel, Niko; Mahfouz, Ahmed; ...
    Publisher: figshare
    Project: NSF | CAREER: Algorithms for Ne... (1053753), SNSF | Defining the identity and... (CRSII5_177208), NHMRC | Combining human genetics ... (1112681), SNSF | Beyond the average: compu... (310030_175841), NIH | QuBBD: Viral Evolution an... (1R01EB025022-01), EC | MERIC (609883), NIH | Statistical Methods for t... (4R00HG009007-03), CIHR , SNSF | The structure and functio... (310030B_182828), NWO | Statistical Models for St... (2300178920),...

    Abstract The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands—or even millions—of cells analyzed in a single experiment amount to a data revolution in singl...

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  • other research product . Collection . 2020
    Authors:
    Doretta Caramaschi; Hatcher, Charlie; Mulder, Rosa; Felix, Janine; Cecil, Charlotte; Relton, Caroline; Walton, Esther;
    Publisher: figshare
    Project: EC | LIFECYCLE (733206), WT , UKRI | Mendelian randomization t... (MC_UU_00011/1), EC | DYNAHEALTH (633595), UKRI | Epigenetic Epidemiology (MC_UU_00011/5), EC | LEaDing Fellows (707404), UKRI | Accessible resource for i... (BB/I025263/1), UKRI | Accessible resource for i... (BB/I025751/1), NIH | Epigenetic Pathways to Co... (4R01HD068437-03), NWO | NCHA Subsidiebesluit 2008... (2300155116),...

    Abstract The occurrence of seizures in childhood is often associated with neurodevelopmental impairments and school underachievement. Common genetic variants associated with epilepsy have been identified and epigenetic mechanisms have also been suggested to play a role....

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  • other research product . Collection . Other literature type . 2020
    Open Access
    Authors:
    Moessnang, Carolin; the EU-AIMS LEAP group; Baumeister, Sarah; Tillmann, Julian; Goyard, David; Charman, Tony; Ambrosino, Sara; Baron-Cohen, Simon; Beckmann, Christian; Bölte, Sven; ...
    Publisher: figshare
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), EC | AIMS-2-TRIALS (777394), EC | IMAGEMEND (602450), EC | AGGRESSOTYPE (602805)

    Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the “social brain,” a neural circ...

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  • other research product . Collection . 2020
    Authors:
    Salgado, Catarina; Gruis, Nelleke; Heijmans, Bastiaan; Oosting, Jan; Doorn, Remco;
    Publisher: figshare
    Project: NWO | BBMRI-NL (2300154272), EC | MELGEN (641458), NWO | BBMRI-NL2.0: The NL-Bioba... (2300184368)

    Abstract Background Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathogenic variants in established melanoma susc...

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  • other research product . Collection . 2020
    Authors:
    Aguirre-Gamboa, Raúl; Klein, Niek De; Tommaso, Jennifer Di; Claringbould, Annique; Wijst, Monique GP Van Der; Vries, Dylan De; Brugge, Harm; Oelen, Roy; Võsa, Urmo; Zorro, Maria M.; ...
    Publisher: figshare
    Project: EC | CD-LINK (322698), EC | SYSBIOFUN (310372), NWO | BBMRI-NL (2300154272), NIH | Functional characterizati... (1R01AI137325-01), EC | TANDEM (305279), NIH | Molecular Biology Core (5P30DK043351-19), EC | ImmRisk (637640)

    Abstract Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which are likel...

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  • other research product . Collection . 2020
    Authors:
    Geurtsen, Madelon; Jaddoe, Vincent; Salas, Lucas; Santos, Susana; Felix, Janine;
    Publisher: figshare
    Project: EC | EMBRYOandLATERHEALTH (648916), NIH | Epigenetic Pathways to Co... (4R01HD068437-03), NWO | NCHA Subsidiebesluit 2008... (2300155116), NIH | HealthyMe/MiSalud Smartph... (1R01LM013039-01), EC | LIFECYCLE (733206)

    Abstract Background Non-alcoholic fatty liver disease is the most common chronic liver disease in children in western countries. Adverse early-life exposures are associated with higher liver fat percentages in children. Differential DNA methylation may underlie these as...

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  • other research product . Collection . 2020
    Authors:
    Tengeler, Anouk C.; Dam, Sarita A.; Wiesmann, Maximilian; Naaijen, Jilly; Bodegom, Miranda Van; Belzer, Clara; Dederen, Pieter J.; Verweij, Vivienne; Franke, Barbara; Kozicz, Tamas; ...
    Publisher: figshare
    Project: EC | MiND (643051), NWO | XCiDE: Crossing the Combu... (2300153186), EC | CoCA (667302), EC | Eat2beNICE (728018)

    Abstract Background The impact of the gut microbiota on host physiology and behavior has been relatively well established. Whether changes in microbial composition affect brain structure and function is largely elusive, however. This is important as altered brain struct...

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  • other research product . Collection . Other literature type . 2019
    Open Access
    Authors:
    Gervin, Kristina; Salas, Lucas; Bakulski, Kelly; Zelm, Menno; Koestler, Devin; Wiencke, John; Duijts, Liesbeth; HenriĂŤtte Moll; Kelsey, Karl; Kobor, Michael; ...
    Publisher: figshare
    Project: NIH | Prenatal exposure to meta... (1R01ES025531-01A1), EC | LIFECYCLE (733206), NIH | (PQ3) Immune epigenetic b... (5R01CA216265-02), EC | DrugsInPregnancy (639377), EC | ERA-HDHL (696295), NIH | Exposure Assessment Core (5P30ES017885-04), NIH | Characterizing disparitie... (1R01AG055406-01A1), NIH | Racial inequalities in he... (1R01MD013299-01), NIH | Folic Acid Prevention Pat... (5R01ES025574-03), EC | DYNAHEALTH (633595),...

    Abstract Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association studies of prenatal exposures. Accounting for cell type composition is critical in such studies as it reduces confounding due to the cell specificity of DNA methylation (DNAm)....

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  • other research product . 2019
    Open Access English
    Authors:
    Geerlings, Nicole M. J.; Zetsche, Eva-Maria; Hidalgo-Martinez, Silvia; Middelburg, Jack J.; Meysman, Filip J. R.;
    Project: EC | BIPHA (660481), EC | SEDBIOGEOCHEM2.0 (306933), NWO | The impact of cable bacte... (2300189430)

    Cable bacteria are multicellular, filamentous microorganisms that are capable of transporting electrons over centimeter-scale distances. Although recently discovered, these bacteria appear to be widely present in the seafloor, and when active they exert a strong imprint...

  • other research product . Collection . 2019
    Authors:
    Kiragosyan, Karine; Veelen, Pieter; Suyash Gupta; Tomaszewska-Porada, Agnieszka; Roman, Pawel; Timmers, Peer;
    Publisher: Figshare
    Project: NWO | Microbes for health and e... (2300181602), EC | WaterSEED (665874)

    Abstract Chemolithoautotrophic sulfur-oxidizing bacteria (SOB) are crucial key players in biotechnological processes to remove hydrogen sulfide from sour gas streams. Several different haloalkaliphilic SOB have been detected and isolated from lab- and full-scale facilit...

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43 research outcomes, page 1 of 5