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25 research outcomes, page 1 of 3
  • other research product . Other ORP type . 2020
    Open Access English
    Authors:
    Flechard, Chris R.; Ibrom, Andreas; Skiba, Ute; de Vries, Wim; Van Oijen, Marcel; Cameron, David R.; Dise, Nancy B.; Korhonen, Janne; Buchmann, Nina; Legout, Arnaud; ...
    Project: NWO | EFFECT Exploiting Filtere... (2300149327), EC | ECLAIRE (282910), UKRI | UK Status, Change and Pro... (NE/R016429/1)

    The impact of atmospheric reactive nitrogen (Nr) deposition on carbon (C) sequestration in soils and biomass of unfertilized, natural, semi-natural and forest ecosystems has been much debated. Many previous results of this dC∕dN response were based on changes in carbon ...

  • other research product . Other ORP type . 2018
    Open Access English
    Authors:
    Doestzada, Marwah; Vich Vila, Arnau; Zhernakova, Alexandra; Koonen, Debby P Y; Weersma, Rinse K; Touw, Daan J; Kuipers, Folkert; Wijmenga, Cisca; Fu, Jingyuan;
    Country: Netherlands
    Project: NWO | Understanding the causal ... (2300184638), EC | BabyVir (715772), EC | CD-LINK (322698)

    Inter-individual heterogeneity in drug response is a serious problem that affects the patient's wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic ...

  • other research product . Other ORP type . 2018
    Open Access English
    Authors:
    van Beek, Nienke; Klionsky, Daniel J; Reggiori, Fulvio;
    Country: Netherlands
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), EC | DRIVE (765912)

    The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis. Those functions include adaptation to starvation, cell dev...

  • other research product . Other ORP type . 2018
    Open Access English
    Authors:
    Cao, Fangyuan; Zwinderman, Martijn R H; Dekker, Frank J;
    Country: Netherlands
    Project: EC | FWGDEKKER (309782), NWO | Expanding the molecular t... (2300172468)

    Histone deacetylases (HDACs) are epigenetic drug targets that have gained major scientific attention. Inhibition of these important regulatory enzymes is used to treat cancer, and has the potential to treat a host of other diseases. However, currently marketed HDAC inhi...

  • other research product . Other ORP type . 2018
    Open Access English
    Authors:
    Weiden, J.; Tel, J.; Figdor, C.G.;
    Country: Netherlands
    Project: NWO | The Institute for Chemica... (2300181608), EC | PATHFINDER (269019)

    Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic i...

  • other research product . Other ORP type . 2018
    Open Access English
    Authors:
    Aloi, Antonio; Voets, Ilja K.;
    Country: Netherlands
    Project: NWO | Research Centre for Funct... (2300176518), EC | PRISM (635928)

    Super-resolution microscopy (SRM), also known as nanoscopy, has gained ground in the past decade as a valuable imaging and characterization tool to investigate sub-μm architectures. Widespread is its usage in cell biology and biophysics, while visualization of the inner...

  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Bernstein, D.J.; Lange, T.;
    Country: Netherlands
    Project: EC | PQCRYPTO (645622), NWO | Computational number theo... (2300163763), NSF | TWC: Option: Medium: Coll... (1314919)

    Cryptography is essential for the security of online communication, cars and implanted medical devices. However, many commonly used cryptosystems will be completely broken once large quantum computers exist. Post-quantum cryptography is cryptography under the assumption...

  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Gribling, Sander; Laat, David; Laurent, Monique;
    Country: Netherlands
    Project: EC | QPROGRESS (615307), NWO | Approximation Algorithms,... (2300181725)

    We use techniques from (tracial noncommutative) polynomial optimization to formulate hierarchies of semidefinite programming lower bounds on matrix factorization ranks. In particular, we consider the nonnegative rank, the completely positive rank, and their symmetric an...

  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Country: Netherlands
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J;
    Country: Netherlands
    Project: EC | FWGDEKKER (309782), NWO | Expanding the molecular t... (2300172468)

    Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlyi...

25 research outcomes, page 1 of 3