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7 Research products, page 1 of 1

  • Research data
  • Other research products
  • 2017-2021
  • PRONKJEWAIL
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  • Authors: 
    Cong, Yingying; So, Vincent; Tijssen, Marina A. J.; Verbeek, Dineke S.; Reggiori, Fulvio; Mauthe, Mario;
    Publisher: Taylor & Francis
    Project: EC | PRONKJEWAIL (713660)

    The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to six different neurodegenerative disorders, i.e., ß-propeller protein associated neurodegeneration, Rett-like syndrome, intellectual disability, and epileptic encephalopathies includi...

  • Open Access English
    Authors: 
    Märtson, Anne Grete; Veringa, Anette; van den Heuvel, Edwin R.; Bakker, Martijn; Touw, Daan J.; van der Werf, Tjip S.; Span, Lambert F.R.; Alffenaar, Jan Willem C.;
    Project: EC | PRONKJEWAIL (713660)

    Posaconazole is indicated for prophylaxis and treatment of invasive aspergillosis. Therapeutic drug monitoring (TDM) of posaconazole is used to optimise drug exposure. The aim of this study was to analyse and describe the TDM practices and exposure of posaconazole table...

  • Authors: 
    Seinen, Jolien; Dieperink, Willem; Mekonnen, Solomon A.; Lisotto, Paola; Hermie J. M. Harmsen; Hiemstra, Bart; Alewijn Ott; Schultz, Daniel; Lalk, Michael; Oswald, Stefan; +3 more
    Publisher: Taylor & Francis
    Project: EC | PRONKJEWAIL (713660)

    Pneumonia is an infection of the lungs, where the alveoli in the affected area are filled with pus and fluid. Although ventilated patients are at risk, not all ventilated patients develop pneumonia. This suggests that the sputum environment may possess antimicrobial act...

  • Authors: 
    Liangde Zheng; Shu, Wen-Jie; Li, Yu-Min; Mari, Muriel; Chaojun Yan; Dehe Wang; Yin, Zhao-Hong; Jiang, Wei; Zhou, Yu; Okamoto, Koji; +4 more
    Publisher: Taylor & Francis
    Project: EC | PRONKJEWAIL (713660)

    Mitophagy is a critical process that safeguards mitochondrial quality control in order to maintain proper cellular homeostasis. Although the mitochondrial-anchored receptor Atg32-mediated cargo-recognition system has been well characterized to be essential for this proc...

  • Other research product . Other ORP type . 2018
    Open Access English
    Authors: 
    van Beek, Nienke; Klionsky, Daniel J; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | DRIVE (765912), EC | PRONKJEWAIL (713660)

    The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis. Those functions include adaptation to starvation, cell dev...

  • Authors: 
    Mauthe, Mario; Idil Orhon; Rocchi, Cecilia; Xingdong Zhou; Luhr, Morten; Kerst-Jan Hijlkema; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Publisher: Taylor & Francis
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

  • Other research product . Other ORP type . 2017
    Open Access English
    Authors: 
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...