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Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 3: Table S2. Hub protein analysis.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311317.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average 
Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 7: Table S6. Pathway enrichment analysis using PANTHER.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311329&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 4: Table S3. Downstream proteins of the Ras network.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311320.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 6: Table S5. Functional analysis of the Ras network proteins using SysGO.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311326.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022Taylor & Francis SFI | Effect of genome diversit... (19/FFP/6668)Daneshnia, Farnaz; de Almeida Júnior, João N.; Arastehfar, Amir; Lombardi, Lisa; Shor, Erika; Moreno, Lis; Mendes, Ana Verena; Barberino, Maria Goreth; Yamamoto, Danilo Thomaz; Butler, Geraldine; Perlin, David S.; Colombo, Arnaldo Lopes;Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which are associated with poor clinical outcomes despite antifungal treatment. The extreme burden imposed on clinical facilities during the COVID-19 pandemic has provided a permissive environment for the emergence of clonal outbreaks of multiple Candida species, including C. auris and C. parapsilosis. Here we report the largest clonal CAC outbreak to date caused by fluconazole resistant (FLZR) and echinocandin tolerant (ECT) C. parapsilosis. Sixty C. parapsilosis strains were obtained from 57 patients at a tertiary care hospital in Brazil, 90% of them were FLZR and ECT. Although only 35.8% of FLZR isolates contained an ERG11 mutation, all of them contained the TAC1L518F mutation and significantly overexpressed CDR1. Introduction of TAC1L518F into a susceptible background increased the MIC of fluconazole and voriconazole 8-fold and resulted in significant basal overexpression of CDR1. Additionally, FLZR isolates exclusively harboured E1939G outside of Fks1 hotspot-2, which did not confer echinocandin resistance, but significantly increased ECT. Multilocus microsatellite typing showed that 51/60 (85%) of the FLZR isolates belonged to the same cluster, while the susceptible isolates each represented a distinct lineage. Finally, biofilm production in FLZR isolates was significantly lower than in susceptible counterparts Suggesting that it may not be an outbreak determinant. In summary, we show that TAC1L518F and FKS1E1393G confer FLZR and ECT, respectively, in CAC-associated C. parapsilosis. Our study underscores the importance of antifungal stewardship and effective infection control strategies to mitigate clonal C. parapsilosis outbreaks.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.20983588&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 1: Table S1. All protein-protein interactions (PPI) of the Ras-network sorted by layer.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311311.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 10: Table S7. Biological process enrichment of class-specific proteins.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311305&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022Microbiology Society SFI | Phage-host interactome of... (15/SIRG/3430), SFI | Functional analysis of th... (13/IA/1953)Parlindungan, Elvina; McDonnell, Brian; Lugli, Gabriele Andrea; Ventura, Marco; van Sinderen, Douwe; Mahony, Jennifer;Supplementary Material for 'Dairy streptococcal cell wall and exopolysaccharide genome diversity', as published in Microbial Genomics.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.17080283&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 5: Table S4. Effector-related feedback analysis.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311323&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 8: Network S1. CellDesigner diagram as zip.
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Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 3: Table S2. Hub protein analysis.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311317.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 7: Table S6. Pathway enrichment analysis using PANTHER.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311329&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 4: Table S3. Downstream proteins of the Ras network.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311320.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | Quantitative and systems ... (16/FRL/3886), SFI | A national platform for c... (18/RI/5702)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 6: Table S5. Functional analysis of the Ras network proteins using SysGO.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311326.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022Taylor & Francis SFI | Effect of genome diversit... (19/FFP/6668)Daneshnia, Farnaz; de Almeida Júnior, João N.; Arastehfar, Amir; Lombardi, Lisa; Shor, Erika; Moreno, Lis; Mendes, Ana Verena; Barberino, Maria Goreth; Yamamoto, Danilo Thomaz; Butler, Geraldine; Perlin, David S.; Colombo, Arnaldo Lopes;Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which are associated with poor clinical outcomes despite antifungal treatment. The extreme burden imposed on clinical facilities during the COVID-19 pandemic has provided a permissive environment for the emergence of clonal outbreaks of multiple Candida species, including C. auris and C. parapsilosis. Here we report the largest clonal CAC outbreak to date caused by fluconazole resistant (FLZR) and echinocandin tolerant (ECT) C. parapsilosis. Sixty C. parapsilosis strains were obtained from 57 patients at a tertiary care hospital in Brazil, 90% of them were FLZR and ECT. Although only 35.8% of FLZR isolates contained an ERG11 mutation, all of them contained the TAC1L518F mutation and significantly overexpressed CDR1. Introduction of TAC1L518F into a susceptible background increased the MIC of fluconazole and voriconazole 8-fold and resulted in significant basal overexpression of CDR1. Additionally, FLZR isolates exclusively harboured E1939G outside of Fks1 hotspot-2, which did not confer echinocandin resistance, but significantly increased ECT. Multilocus microsatellite typing showed that 51/60 (85%) of the FLZR isolates belonged to the same cluster, while the susceptible isolates each represented a distinct lineage. Finally, biofilm production in FLZR isolates was significantly lower than in susceptible counterparts Suggesting that it may not be an outbreak determinant. In summary, we show that TAC1L518F and FKS1E1393G confer FLZR and ECT, respectively, in CAC-associated C. parapsilosis. Our study underscores the importance of antifungal stewardship and effective infection control strategies to mitigate clonal C. parapsilosis outbreaks.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.20983588&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 1: Table S1. All protein-protein interactions (PPI) of the Ras-network sorted by layer.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311311.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 10: Table S7. Biological process enrichment of class-specific proteins.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311305&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022Microbiology Society SFI | Phage-host interactome of... (15/SIRG/3430), SFI | Functional analysis of th... (13/IA/1953)Parlindungan, Elvina; McDonnell, Brian; Lugli, Gabriele Andrea; Ventura, Marco; van Sinderen, Douwe; Mahony, Jennifer;Supplementary Material for 'Dairy streptococcal cell wall and exopolysaccharide genome diversity', as published in Microbial Genomics.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.17080283&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 5: Table S4. Effector-related feedback analysis.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311323&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Dataset 2022figshare SFI | A national platform for c... (18/RI/5702), SFI | Quantitative and systems ... (16/FRL/3886)Catozzi, Simona; Ternet, Camille; Gourrege, Alize; Wynne, Kieran; Oliviero, Giorgio; Kiel, Christina;Additional file 8: Network S1. CellDesigner diagram as zip.
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You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.19311332.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!