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Aneuploidy is a hallmark of cancer cells, characterized by a chromosome’s number which is not a multiple of the haploid complement12,15. Aneuploidy is characterized by an unbalanced genomic content. Aneuploidy as a therapeutic target is promising because it is a hallmar...

In France, 380,000 new cancer diagnoses are made each year and 60% of these cancers are treated by radiotherapy, which uses ionizing radiation to destroy tumor cells. Radiation therapy causes undesirable radiotoxic effects on healthy tissues located in the radiation fie...

Cystic fibrosis (CF) is due to CFTR gene pathogenic variants and has no curative treatment to date. The main cause of morbidity and mortality in CF patients is respiratory failure, due to cycles of infection and inflammation responsible for progressive lung tissue degra...

The transfer of a competent embryo into a uterine cavity during the implantion window is a major objective to ensure success in in vitro fertilization (IVF). My thesis work contributes to (i) the identification of new biomarkers for the evaluation of endometrial recepti...

Cognitive deficits is a fundamental characteristic of schizophrenia where the most affected function are particularly memory, attention, motor skills, executive functions and social cognition. Cognitive assessment is one of the best indicators of the functional and soci...

Artificial intelligence covers all the techniques and theories that enable an artificial system to act in a so-called intelligent way, i.e., as a human or an animal would. This field of research has recently made significant progress which have enabled it to surpass man...

The monitoring of physiopathological consequences of the mechanical ventilation seems to be fundamental for the management of patients assisted with veno-venous ECMO for refractory acute respiratory distress syndrome (ARDS). Electrical impedance tomography (EIT) allows ...

Lymphoma is the sixth most common cancer in France with 15,000 new cases diagnosed and 4,500 deaths each year. Lymphomas are very heterogeneous diseases both in clinical and phenotypic aspects. The development of immunohistochemistry, cytogenetics and more recently next...

Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) infection is the cause of most chronic hepatitis B in countries with high HBV endemicity. Prevention is based on early vaccination of newborns at birth and, for HBsAg-positive women, on the administration of...

The guideline of this thesis is to add polyphenols to the liquid used for the setting of dental root canal repair cements with the assumption that this family of molecules, known for their ability to adsorb on the surface of all types of materials, promote interparticle...