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10 research outcomes, page 1 of 1
  • publication . Article . 2020
    Open Access English
    Authors:
    Frank Møller Aarestrup; A. Albeyatti; W. J. Armitage; Charles Auffray; L. Augello; Rudi Balling; N. Benhabiles; G. Bertolini; Jan G. Bjaalie; Michaela Black; ...
    Publisher: BMC
    Project: EC | SYSCID (733100), EC | ERA PerMed (779282), EC | DEFORM (710246), EC | ETRIKS (115446), EC | EHR4CR (115189), EC | MedBioinformatics (634143), EC | PANCARESURFUP (257505), EC | ICT4DEPRESSION (248778), EC | COMPARE (643476), EC | INSTRUCT-ULTRA (731005),...

    The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation C...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Norman E. Davey; M. Madan Babu; Martin Blackledge; Alan Bridge; Salvador Capella-Gutierrez; Zsuzsanna Dosztányi; Rachel Drysdale; Richard J. Edwards; Arne Elofsson; Isabella C. Felli; ...
    Publisher: F1000 Research Limited
    Project: EC | IDPfun (778247), UKRI | Bioinformatics Resources ... (BB/P024092/1), NIH | UniProt supporting an int... (3U24HG007822-05S1), WT | Protein Data Bank in Euro... (104948)

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

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  • publication . Article . 2019
    Open Access
    Authors:
    Karin H. Müller; Robert Hayward; Rakesh Rajan; Meredith Whitehead; Andrew M. Cobb; Sadia Ahmad; Mengxi Sun; Ieva Goldberga; Rui Li; Uliana Bashtanova; ...
    Publisher: Elsevier BV
    Project: EC | iNEXT (653706), UKRI | Nano-Optics to controlled... (EP/L027151/1), UKRI | Cambridge NanoScience thr... (EP/G037221/1)

    Müller et al. investigate the physicochemical process of extracellular matrix calcification in both physiological (bone) and pathological (vascular calcification) contexts. They find that oxidative stress-induced poly(ADP-ribose) nucleates calcium phosphate mineral crys...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Zouridakis, Marios; Papakyriakou, Athanasios; Ivanov, Igor A.; Kasheverov, Igor E.; Tsetlin, Victor; Tzartos, Socrates; Giastas, Petros;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | BIOSTRUCT-X (283570)

    The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−), and the α10(+)/α9(−). The maj...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Petros Giastas; Margarete Neu; Paul Rowland; Efstratios Stratikos;
    Project: EC | iNEXT (653706)

    Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that helps generate peptides presented by Major Histocompatibility Complex Class I (MHC class I) molecules and is an emerging target for immunotherapy applications. Despite almost two decades of r...

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  • publication . Article . 2016
    Restricted
    Authors:
    Christina E. Drakou; Katerina E. Tsitsanou; Constantinos Potamitis; Dimitrios Fessas; Maria I. Zervou; Spyros E. Zographos;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ENAROMATIC (222927), EC | ARCADE (245866), EC | BIOSTRUCT-X (283570)

    Anopheles gambiae Odorant Binding Protein 1 in complex with the most widely used insect repellent DEET, was the first reported crystal structure of an olfactory macromolecule with a repellent, and paved the way for OBP1-structure-based approaches for discovery of new ho...

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  • publication . Article . 2016
    Open Access
    Authors:
    Ison, Jon; Rapacki, Kristoffer; Ménager, Hervé; Kalaš, Matúš; Rydza, Emil; Chmura, Piotr; Anthon, Christian; Beard, Niall; Berka, Karel; Bolser, Dan; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: NIH | Gene Ontology Consortium (5U41HG002273-14), EC | ELIXIR-EXCELERATE (676559), EC | BIOMEDBRIDGES (284209)

    International audience; Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora of databases and tools are deployed, in techni...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Afonso M.S. Duarte; Fotis Psomopoulos; Christophe Blanchet; Alexandre M. J. J. Bonvin; Manuel Corpas; Alain Franc; Rafael C. Jimenez; Jesús Marco de Lucas; Tommi Nyrönen; Gergely Sipos; ...
    Project: FCT | SFRH/BPD/78075/2011 (SFRH/BPD/78075/2011), EC | BIOMEDBRIDGES (284209), WT , AKA | ELIXIR - Data for Life Eu... (273655), FCT | EXPL/BBB-BEP/1356/2013 (134381), EC | WENMR (261572), EC | EGI-INSPIRE (261323)

    This is an open-access article.-- et al.

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  • publication . Article . 2014
    Open Access English
    Authors:
    Antigoni Nikolaki; Anastasia Papadioti; Katerina Arvaniti; Eleni Kassotaki; Julian D. Langer; Georgios Tsiotis;
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier B.V.
    Project: EC | BIOSOLENUTI (229927)

    AbstractIn this study, we have performed a systematic analysis of Pseudomonas sp. strain phDV1 membrane protein complexes by growing the strain in lysogeny broth medium, and medium containing glucose or phenol as sole carbon sources. In order to study the membrane compl...

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  • publication . Article . 2013
    Open Access
    Authors:
    Ilona A. Kesisova; Konstantinos Nakos; Avgi Tsolou; Dimitrios Angelis; Joe Lewis; Aikaterini Chatzaki; Bogos Agianian; Athanassios Giannis; Maria Koffa;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: EC | PCUBE (227764), EC | BIOSTRENGTH (229971)

    Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases are a family of such targets. In this study, from a panel of 105 potential small-mol...

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10 research outcomes, page 1 of 1