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Phage therapy could offer a safe and effective alternative to antibiotic treatment of infections caused by Gram-positive bacterium Staphylococcus aureus that have emerged as a significant threat in hospital and community environment and is attracting growing interest among clinicians. The legislation process of approving the phage therapeutics by pharmaceutical authorities requires rapid analytical techniques for assessment of phage activity. Here, we present a three-step method for on-line monitoring the phage effect on bacterial cells dynamically adhered from microliter volumes of high conductivity matrix onto the inner surface of fused silica capillary with a part etched with supercritical water. Phage K1/420 particles of the Kayvirus genus generated by propagation on the host S. aureus cells together with the uninfected cells were concentrated, separated and detected using capillary electrophoretic methods. The phage interactions with selected S. aureus strains exhibiting differences in phage susceptibility were compared. The method allowed determination of the phage burst size and time of phage latent period in analyzed strains. Apart from enumeration of bacteriophages by the plaque assays, the proposed method is suitable for phage activity testing.

The book deals with the theme of antidemocratic and nationalistic tendencies in the Czech and German Catholic milieu in Czechoslovakia in the interwar period. The issue is mentioned in the context of Central Europe - primarily with particular emphasis on developments in Austria and Germany. Attention is also devoted to papal politics of this period, which acted offensively in a public area and was simultaneously confronted with the rise of authoritarian and totalitarian regimes in Europe.

This paper summarizes the status of the COMPASS tokamak, its comprehensive diagnostic equipment and plasma scenarios as a baseline for the future studies. The former COMPASS-D tokamak was in operation at UKAEA Culham, UK in 1992-2002. Later, the device was transferred to the Institute of Plasma Physics of the Academy of Sciences of the Czech Republic (IPP AS CR), where it was installed during 2006-2011. Since 2012 the device has been in a full operation with Type-I and Type-III ELMy H-modes as a base scenario. This enables together with the ITER-like plasma shape and flexible NBI heating system (two injectors enabling co- or balanced injection) to perform ITER relevant studies in different parameter range to the other tokamaks (ASDEX-Upgrade, DIII-D, JET) and to contribute to the ITER scallings. In addition to the description of the device, current status and the main diagnostic equipment, the paper focuses on the characterization of the Ohmic as well as NBI-assisted H-modes. Moreover, Edge Localized Modes (ELMs) are categorized based on their frequency dependence on power density flowing across separatrix. The filamentary structure of ELMs is studied and the parallel heat flux in individual filaments is measured by probes on the outer mid-plane and in the divertor. The measurements are supported by observation of ELM and inter-ELM filaments by an ultra-fast camera.

In this work we investigate the solvability and the approximate construction of solutions of certain types of regular non-linear boundary value problems for systems of ordinary differential equations on a compact interval. According to the scheme suggested, the solution is sought for as the limit of a uniformly convergent parametrised sequence of functions constructed in an analytical form and depending on the properties of concrete boundary conditions and non-linearities. The values of the numerical parameters introduced artificially into the scheme should then be determined by solving a certain system of algebraic or transcendental equations. The work consists of 10 sections, the theoretical results are illustrated by examples. A number of exercises are also given.

Abstract Atmospheric infrasound of frequencies 0.1–4 Hz observed in Central Europe during convective storms on 9–10 July 2011 from 21:00 to 02:57 UT was analysed. Azimuth of signal arrival followed positions of the convective storms passing over the region of measurements from south-west to north-east. Significant variations in azimuths of signal arrival (up to 105°) occurred periodically between 21:30 and 23:00 UT, at the time of maximum development of convective storms. Sprites (discharges in the mesosphere) seem to be potential sources of these infrasound signals. Stable infrasound arrivals were observed between 02:00 and 02:57 UT from direction where abating convective storms were located.

In this article, factors concerning reintegration and resocialization of offenders into society are summarized. The article defines socialization and resocialization and further concentrates on studies, which define different clasifications of risk and protective factors of reintegration. In the end, the article concentrates on different concepts pertaining to reintegration and resocialization.

We show that the existence of a homeomorphism between omega(*)(0) and omega(*)(1) entails the existence of a non-trivial autohomeomorphism of omega(*)(0). This answers Problem 441 in [8]. We also discuss the joint consistency of various consequences of omega(*)(0) and omega(*)(1) being homeomorphic.

In the present article the author points out the fact that no mention of the Cyrillo-Methodian mission to Moravia, generally considered one of the most important Byzantine ecclesiastical missions ever sent abroad, appears in the known Byzantine sources. He explains this omission from the perspective of political interests of Byzantium from which this mission was a failure. Another reason may have been the introduction of the Slavonic vernacular into liturgy, which was not an application of the allegedly common Byzantine missionary practice but a novel initiative of Constantine-Cyril. The author also focuses on the paradox that this revolutionary innovations, which became a target of fierce attacks of Frankish missionaries and provoked a strong opposition from the Latin clergy in Italy was, though temporarily, approvedy by two Roman popes. The latest paradox of the Cyrillo-Methodian mission was that its cultural legacy, while ignored and even disregarded in Byzantium and later abandoned in the country to which the Thessalonian brothers had been sent, proved one of the most effective means of spreading the Byzantine civilization and spirituality among the south and east Slavonic nations.

Metalearning is becoming an increasingly important methodology for extracting knowledge from a database of available training datasets to a new (independent) dataset. While the concept of metalearning is becoming popular in statistical learning and readily available also for the analysis of economic datasets, not much attention has been paid to its limitations and disadvantages. To the best of our knowledge, the current paper represents the first illustration of metalearning sensitivity to data contamination by noise or outliers. For this purpose, we use various linear regression estimators (including highly robust ones) over a set of 24 datasets with economic background and perform a metalearning study over them as well as over the same datasets after an artificial contamination. The results reveal the whole process to remain rather sensitive to data contamination and some of the standard classifiers turn out to yield unreliable results. Nevertheless, using a robust classification method does not bring a desirable improvement. Thus, we conclude that the task of robustification of the whole metalearning methodology is more complex and deserves a systematic future research.