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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Abbott, B.P.; Abbott, R.; Acernese, F.; Adhikari, R.; +196 Authors

    VizieR online Data Catalogue associated with article published in journal Astronomical Journal (AAS) with title 'Searches for gravitational waves from known pulsars with science run 5 LIGO data.' (bibcode: 2010ApJ...713..671A)

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Strasbourg Astronomi...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    B2FIND
    Dataset . 2012
    Data sources: B2FIND
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Strasbourg Astronomi...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      B2FIND
      Dataset . 2012
      Data sources: B2FIND
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Wilson, Shaun; Gibson, Rachel; Haller, Max; Hoellinger, Franz; +85 Authors

    Citizen and state. Topics: Qualities of a good citizen; attitude toward the right of public meetings for religious extremists, people who want to over throw the government by force, or people prejudiced against any racial or ethnic group; social and political participation; memberships; importance of different people`s rights in democracy (scale);estimation of political influence possibilities (political efficacy);likeliness of counter-action against an unjust law and expected chance of serious attention to people`s demand; interest in politics; personal trust in politicians and people; political discussions with friends; opinion leadership in politics; national sovereignty and attitude to international organisations; attitude to the action of political parties; real policy choice between parties; attitude toward a referendum; level of honesty and fairness in the last national election; commitment to serve people and likeliness to correct own mistakes in public service; corruption in public service; functioning of democracy at present, in the past and in the future; frequencies of media use; respect for people and tolerance in case of disagreement; self-description of the habitation (residence); voter participation; voting behaviour (recall).Demography: Sex; age; marital-status; steady life-partner; education; current employment status; hours worked weekly; occupation (ISCO 1988);working for private or public sector or self-employed; if self-employed: number of employees; supervisor function; trade union membership; current employment status (ISCO 1988); earnings; family income; household size; household composition; party affiliation; participation in last election; religious denomination; attendance of religious services; self-placement on a top-bottom scale; region; size of community; type of community: urban-rural area; ethnicity, nationality and family-origin. Additionally coded: administrative mode of data-collection. Bürger und Staat: Eigenschaften eines guten Bürgers; Versammlungsfreiheit für religiöse Fanatiker, Revolutionäre, Ethnozentristen; soziale und politische Partizipation; Mitgliedschaften; Wichtigkeit verschiedener Bürgerrechte; Politikverdrossenheit und politische Informiertheit; Einschätzung von Einflussmöglichkeiten auf die Politik (political efficacy); politisches Interesse; Vertrauen in die Politiker; Vertrauen in Mitmenschen; politische Arbeit im Alltag; nationale Souveränität und internationale Organisationen; politische Parteien und Bürgerengagement; Bewertung des Wahlprozess; Bürgernähe, Selbstregulierung und Korruption im öffentlichen Dienst; Funktionierender Demokratie jetzt, vor 10 Jahren, in 10 Jahren; Einstellung zur Einschränkung von Bürgerrechten. Selbsteinschätzung persönlicher Eigenschaften; Selbsteinstufung auf einer Oben-Unten-Skala; Selbstbeschreibung des Wohnorts; Wahlbeteiligung; Wahlrückerinnerung. Demographie: Geschlecht; Geburtsmonat; Geburtsjahr; Alter; allgemeiner Schulabschluss; berufliche Ausbildung; Erwerbsstatus; Angaben zum gegenwärtigen Beruf (ISCO 1988); Zugehörigkeit zum öffentlichen Dienst; berufliche Leitungsfunktion; Wochenarbeitszeit; Dauer von Arbeitslosigkeit; Nebenerwerbstätigkeit; Status der Nichterwerbstätigkeit; Angaben zum ehemaligen Beruf; Zeitpunkt der Beendigung hauptberuflicher Erwerbstätigkeit; Angaben zum ersten Beruf; Familienstand; Staatsbürgerschaft (Nationalität); Herkunft, Wohndauer und Mobilität; Befragteneinkommen; Konfession bzw. Religionszugehörigkeit; Kirchgangshäufigkeit; Mitgliedschaft des Befragten in einer Gewerkschaft oder Partei; Wahlabsicht(Sonntagsfrage); Wahlrückerinnerung; Region; politische Gemeindegröße. Sampling procedures differ for the individual countries: Partly simple, partly multi-stage stratified random sample of respondents 18 years old and older, exclusion: Finland (15), Japan (16), South Africa (16) and the Netherlands (16). Personen im Alter von 18 Jahren und älter Ausnahme: Finnland (15), Japan (16), Südafrika (16) und Niederlande (16)

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Saunois, Marielle; Stavert, Ann R.; Poulter, Ben; Bousquet, Philippe; +87 Authors

    Supplement containing data related to the 2019 Global Carbon Methane Budget from the Global Carbon Project. The original article is: Saunois et al: . https://doi.org/10.5194/essd -12-1561-2020 Further information is available on: https://www.globalcarbonproject.org/methanebudget/. File Global_Methane_Budget_2000_2017_v2.0.xlsx includes the following: 1. Summary. 2. CH4 observations. 3. Antropogenic emissions. 4. 2000-2009 Bottom-Up Budget. 5. 2000-2009 Top-Down budget. 6. 2008-2017 Bottom-Up budget. 7. 2008-2017 Top-Down budget. 8. 2007 Bottom-Up budget. 9. 2017 Top-Down budget. 10. Contributor list.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    ICOS Carbon Portal
    Dataset . 2020
    Data sources: Datacite
    ICOS Carbon Portal
    Dataset . 2020
    Data sources: B2FIND
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      ICOS Carbon Portal
      Dataset . 2020
      Data sources: Datacite
      ICOS Carbon Portal
      Dataset . 2020
      Data sources: B2FIND
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Asselta, Rosanna; Paraboschi, Elvezia Maria; Gerussi, Alessio; Cordell, Heather J; +28 Authors

    Link to dataset related to article "X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis" Abstract Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 �� 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 �� 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 �� 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 �� 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    ZENODO
    Dataset . 2021
    Data sources: Datacite
    ZENODO
    Dataset . 2021
    Data sources: ZENODO
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      ZENODO
      Dataset . 2021
      Data sources: Datacite
      ZENODO
      Dataset . 2021
      Data sources: ZENODO
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Abbott, B.P.; Abbott, R.; Acernese, F.; Adhikari, R.; +196 Authors

    VizieR online Data Catalogue associated with article published in journal Astronomical Journal (AAS) with title 'Searches for gravitational waves from known pulsars with science run 5 LIGO data.' (bibcode: 2010ApJ...713..671A)

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Strasbourg Astronomi...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    B2FIND
    Dataset . 2012
    Data sources: B2FIND
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Strasbourg Astronomi...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      B2FIND
      Dataset . 2012
      Data sources: B2FIND
      addClaim

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Wilson, Shaun; Gibson, Rachel; Haller, Max; Hoellinger, Franz; +85 Authors

    Citizen and state. Topics: Qualities of a good citizen; attitude toward the right of public meetings for religious extremists, people who want to over throw the government by force, or people prejudiced against any racial or ethnic group; social and political participation; memberships; importance of different people`s rights in democracy (scale);estimation of political influence possibilities (political efficacy);likeliness of counter-action against an unjust law and expected chance of serious attention to people`s demand; interest in politics; personal trust in politicians and people; political discussions with friends; opinion leadership in politics; national sovereignty and attitude to international organisations; attitude to the action of political parties; real policy choice between parties; attitude toward a referendum; level of honesty and fairness in the last national election; commitment to serve people and likeliness to correct own mistakes in public service; corruption in public service; functioning of democracy at present, in the past and in the future; frequencies of media use; respect for people and tolerance in case of disagreement; self-description of the habitation (residence); voter participation; voting behaviour (recall).Demography: Sex; age; marital-status; steady life-partner; education; current employment status; hours worked weekly; occupation (ISCO 1988);working for private or public sector or self-employed; if self-employed: number of employees; supervisor function; trade union membership; current employment status (ISCO 1988); earnings; family income; household size; household composition; party affiliation; participation in last election; religious denomination; attendance of religious services; self-placement on a top-bottom scale; region; size of community; type of community: urban-rural area; ethnicity, nationality and family-origin. Additionally coded: administrative mode of data-collection. Bürger und Staat: Eigenschaften eines guten Bürgers; Versammlungsfreiheit für religiöse Fanatiker, Revolutionäre, Ethnozentristen; soziale und politische Partizipation; Mitgliedschaften; Wichtigkeit verschiedener Bürgerrechte; Politikverdrossenheit und politische Informiertheit; Einschätzung von Einflussmöglichkeiten auf die Politik (political efficacy); politisches Interesse; Vertrauen in die Politiker; Vertrauen in Mitmenschen; politische Arbeit im Alltag; nationale Souveränität und internationale Organisationen; politische Parteien und Bürgerengagement; Bewertung des Wahlprozess; Bürgernähe, Selbstregulierung und Korruption im öffentlichen Dienst; Funktionierender Demokratie jetzt, vor 10 Jahren, in 10 Jahren; Einstellung zur Einschränkung von Bürgerrechten. Selbsteinschätzung persönlicher Eigenschaften; Selbsteinstufung auf einer Oben-Unten-Skala; Selbstbeschreibung des Wohnorts; Wahlbeteiligung; Wahlrückerinnerung. Demographie: Geschlecht; Geburtsmonat; Geburtsjahr; Alter; allgemeiner Schulabschluss; berufliche Ausbildung; Erwerbsstatus; Angaben zum gegenwärtigen Beruf (ISCO 1988); Zugehörigkeit zum öffentlichen Dienst; berufliche Leitungsfunktion; Wochenarbeitszeit; Dauer von Arbeitslosigkeit; Nebenerwerbstätigkeit; Status der Nichterwerbstätigkeit; Angaben zum ehemaligen Beruf; Zeitpunkt der Beendigung hauptberuflicher Erwerbstätigkeit; Angaben zum ersten Beruf; Familienstand; Staatsbürgerschaft (Nationalität); Herkunft, Wohndauer und Mobilität; Befragteneinkommen; Konfession bzw. Religionszugehörigkeit; Kirchgangshäufigkeit; Mitgliedschaft des Befragten in einer Gewerkschaft oder Partei; Wahlabsicht(Sonntagsfrage); Wahlrückerinnerung; Region; politische Gemeindegröße. Sampling procedures differ for the individual countries: Partly simple, partly multi-stage stratified random sample of respondents 18 years old and older, exclusion: Finland (15), Japan (16), South Africa (16) and the Netherlands (16). Personen im Alter von 18 Jahren und älter Ausnahme: Finnland (15), Japan (16), Südafrika (16) und Niederlande (16)

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Saunois, Marielle; Stavert, Ann R.; Poulter, Ben; Bousquet, Philippe; +87 Authors

    Supplement containing data related to the 2019 Global Carbon Methane Budget from the Global Carbon Project. The original article is: Saunois et al: . https://doi.org/10.5194/essd -12-1561-2020 Further information is available on: https://www.globalcarbonproject.org/methanebudget/. File Global_Methane_Budget_2000_2017_v2.0.xlsx includes the following: 1. Summary. 2. CH4 observations. 3. Antropogenic emissions. 4. 2000-2009 Bottom-Up Budget. 5. 2000-2009 Top-Down budget. 6. 2008-2017 Bottom-Up budget. 7. 2008-2017 Top-Down budget. 8. 2007 Bottom-Up budget. 9. 2017 Top-Down budget. 10. Contributor list.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    ICOS Carbon Portal
    Dataset . 2020
    Data sources: Datacite
    ICOS Carbon Portal
    Dataset . 2020
    Data sources: B2FIND
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit A...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      ICOS Carbon Portal
      Dataset . 2020
      Data sources: Datacite
      ICOS Carbon Portal
      Dataset . 2020
      Data sources: B2FIND
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Asselta, Rosanna; Paraboschi, Elvezia Maria; Gerussi, Alessio; Cordell, Heather J; +28 Authors

    Link to dataset related to article "X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis" Abstract Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 �� 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 �� 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 �� 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 �� 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    ZENODO
    Dataset . 2021
    Data sources: Datacite
    ZENODO
    Dataset . 2021
    Data sources: ZENODO
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      ZENODO
      Dataset . 2021
      Data sources: Datacite
      ZENODO
      Dataset . 2021
      Data sources: ZENODO
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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