• Open Access close
• Restricted close
• Open Source close
• Publications close
• Research software close
• Other research products close
• BR close
• English close
• Corona Virus Disease close

EXCLI Journal; 20:Doc276; ISSN 1611-2156

In Brazil, the last country in the Americas to abolish slavery, the effects of colonization reverberate in the insurgence of a necropolitics that directly affects Black youth and children. According to the Brazilian Forum of Public Safety, between the years of 2016 and 2020, 35 thousand people from 0 to 17 years old were killed in violent ways. In 2021, around 7 children or teenagers were victims of lethal violence per day. For such, the text updated the condition of contemporary necropolitics considering its colonizing genealogy, having as central axis the comprehension of «the complex of Miguel Otávio», (Souza and Carvalho, 2022, p. 7) as the capacity whether rational or not, conscious or unconscious, of adultcentrism to banalize the risks to which children are submitted, to the point of dying in gratuitous, stupid, violent, irresponsible and negligent forms. Considering examples such as Miguel Otávio Santana, who was 4 years old and was killed due to infant abandonment, and João Pedro Mattos, who was 14 years old and was shot by the police with a rifle, both cases taking place in the most rigid period of the COVID-19 quarantine, it is possible to understand that such processes educate the Brazilian society to treat differences as a synonym to inequalities and that adultcentrism is key in the composition of the Brazilian racism that sustains the death of Black children. Educazione interculturale, Vol. 21 No. 1 (2023): Education in a world of conflict and division

Estamos atravessando uma crise humanitária multidimensional sobre a qual temos mais questionamentos que certezas, e neste cenário, as questões relacionadas à saúde mental geram grande preocupação. Assim, o presente estudo teve como objetivo compreender de que forma o pensamento crítico tem abordado as questões relacionadas à saúde mental em tempos de pandemia de Covid-19. A metodologia utilizada foi a pesquisa bibliográfica, através do estudo de publicações científicas em periódicos e livros, configurando-se uma investigação analítica e crítico-argumentativa. Como resultado, compreendeu-se que para os diferentes autores do pensamento crítico, em especial no contexto latino-americano, é necessário a construção de um outro mundo para além da exploração, um exemplo é a utopia do bem viver, que, desde o mundo andino, ameríndio, feminista tem coproduzido ações coletivas que apontam para novas formas de viver.

This viewpoint note discusses the covid-19 pandemic from the lens of complexity thinking and resilience engineering (RE). It intends to raise questions and encourage critical thinking on the underlying theoretical foundations of the responses adopted so far to cope with the pandemic. Insights arising from this analysis can be useful for the refinement of complexity and RE theory and practice, as well as for the further development of non-medical practices to address the pandemic and its effects.

SARS‐CoV‐2 pandemic and recurrent dengue epidemics in tropical countries have turned into a global health threat. While both virus‐caused infections may only reveal light symptoms, they can also cause severe diseases. Here, we review the possible antibody‐dependent enhancement (ADE) occurrence, known for dengue infections, when there is a second infection with a different virus strain. Consequently, preexisting antibodies do not neutralize infection, but enhance it, possibly by triggering Fcg receptor‐mediated virus uptake. No clinical data exist indicating such mechanism for SARS‐CoV‐2, but previous coronavirus infections or infection of SARS‐CoV‐2 convalescent with different SARS‐CoV‐2 strains could promote ADE, as experimentally shown for antibodies against the MERS‐CoV or SARS‐CoV spike S protein.

{"references": ["Abolhasani, M., Oakes, S., & Oakes, H. (2017). Music in advertising and consumer identity: The search for Heideggerian authenticity. Marketing Theory 17 (4), 473-490. (Doi: 10.1177/1470593117692021.)", "Aliel, L., Keller, D., & Alvim, V. (2019). A Soundtrack for Atravessamentos : Expanding ecologically grounded methods for ubiquitous music collaborations. In 14th International Symposium on Computer Music Multidisciplinary Research .", "Aliel, L., & Fornari, J. (2015). Creating an ecologically modeled performance through the remote manipulation of multiple soundscapes. NICS Reports , (12), 2.", "Brooks, R. A. (1991). Intelligence without representation. Artificial Intelligence 47 (1), 139-159.", "Brown, A. R., Stewart, D., Hansen, A., & Stewart, A. (2014). Making meaningful musical experiences accessible using the iPad. In Keller, D., Lazzarini, V., & Pimenta, M. S. (Eds.). Ubiquitous music (pp. 65-81). Cham, Springer.", "Carson, T. (2020). On Ecocomposition. Journal of Digital Media & Interaction , 3(5), 133-142.", "Keller, D. (2000). Compositional processes from an ecological perspective. Leonardo Music Journal , 55-60.", "Keller, D. (2001). Social and perceptual dynamics in ecologically-based composition. Electronic Musicological Review , 6.", "Keller, D., Gomes, C., & Aliel, L. (2019). The Handy Metaphor: Bimanual, touchless interaction for the internet of musical things. Journal of New Music Research, 48(4), 385-396.", "Keller, D., Messina, M., & Oliveira, F. Z. (2020). Second Wave Ubiquitous Music. Journal of Digital Media & Interaction , 3(5), 5-20.", "Messina, M., & Aliel, L. (2019). Ubiquitous Music, Gelassenheit and the Metaphysics of Presence: Hijacking the Live Score Piece Ntrallazzu 4. In 14th International Symposium on Computer Music Multidisciplinary Research , 685-695.", "Messina, M., Svidzinski, J., de Menezes Bezerra, D., & da Costa, D. F. (2019). Live Patching and Remote Interaction: A Practice-Based, Intercontinental Approach to Kiwi. In 14th International Symposium on Computer Music Multidisciplinary Research , 696-703.", "Mesz, B., Sigman, M., & Trevisan, M. (2012). A composition algorithm based on crossmodal taste-music correspondences. Frontiers in Human Neuroscience , 6, 71.", "Turchet, L., Fischione, C., Essl, G., Keller, D., & Barthet, M. (2018). Internet of musical things: Vision and challenges. IEEE Access , 6, 61994-62017."]} Picture a world with no mobility. Planes are landed. Urban transportation stopped. Large gatherings are non-existent and everybody is at home. That’s 2020, today. Most countries have reduced social interactions to a minimum. Food markets, drugstores and gas stations remain open. But shopping malls, cinemas, coffee shops and pubs have closed their doors for the foreseeable future. The Covid-19 pandemic is among us, ready to strike the most vulnerable and sometimes also the healthy, rich and posh. Covid-19 impacts every social strata. This is a key difference between this disease and the plagues that have been taking lives in the peripheral countries for decades. Pulmonary and respiratory diseases are among the leading causes of death worldwide. But according to the WHO 1 (2018), the so-called Group I conditions (communicable diseases, maternal conditions arising during pregnancy and childbirth, and nutritional deficiencies) are particularly devastating among the low-income populations. Until today, music making has predominantly been done through face-to-face, synchronous interactions. While it is true that some forms of music making ⎼ for instance, studio post-production or karaoké ⎼ rely on resources that are prepared offline, the implicit target of musical activity is to make sound together, if possible in person and at the same time. The current pandemic has turned the traditional forms of music making into high-risk and in some cases potentially deadly activities. So is music making becoming an activity for a select elite, secluded from the mundane buzz and divorced from community exchanges, again? The answer from the ubimus community is a strong no!

There is a growing demand for unmanned aerial vehicles (UAV) in the industry since they are being used on a large scale in various fields, such as health, security, military missions, agriculture, etc. These vehicles have the potential to increase productivity and savings. However, the increase in production and use of unmanned aerial vehicles requires improving sound decision-making principles, physical, computational security, and relevant technologies by the computing community. They must continually adapt to carry out missions where they face unpredictable problems. The increase in advanced functionality and the demand for computing capacity exposes these vehicles to different security vulnerabilities. These vulnerabilities are growing not only in number but also in sophistication. Researchers and companies have been developing multidisciplinary methodologies and approaches in recent years, trying to solve the most varied protection and safety problems around unmanned aerial vehicles. As in the past, concerns about unmanned aerial vehicles safety were with aggressors and hijackers, now with the domain of civilian application and insertion into the network, circumstances have changed. In this context, this dissertations objective was to advance state-of-the-art through the definition and development of a resilient architecture for unmanned aerial vehicles (STUART - reSilient archiTecture to dynamically manage Unmanned aeriAl vehicle networksundeR atTack) that dynamically manages the network, even when subjected to an attack during a mission, integrating safety and security methods. The architecture is composed of four parts: (1) Anomaly-based detection system, (2) Triage module, (3) Decision-making module, and (4) Resilience module. This dissertation also investigated the incorporation of safety and security as a unified concept in UAV development. The developed architecture was validated by applying specific techniques in each of the parts that compose the architecture. Three tests were performed: one with a real drone and two tests using computer simulation, composed of a base station and a UAV during a vaccine transport mission for COVID-19. The results allow us to conclude that STUART is effective in detecting GPS spoofing. Unlike other architectures found in the literature that focus on specific missions or vulnerabilities, STUART proposes an organizational structure of metrics aggregated for different contexts, ranging from vulnerability detection, filtering false positives, decision-making, and mitigation. Its efficiency has been proven through computational validation using real data from a drone. Na indústria, há uma crescente demanda por veículos aéreos não tripulados, visto que, eles estão sendo usados em larga escala em vários campos, como saúde, segurança, missões militares, agricultura, etc. Esses veículos possuem potencial para aumentar a produtividade e a economia. No entanto, o aumento da produção e utilização desses veículos exigem o aprimoramento de princípios sólidos de tomada de decisão, segurança física, computacional e tecnologias relevantes pela comunidade de computação, pois eles devem continuamente se adaptar para realizar missões onde enfrentam problemas imprevisíveis. O aumento das funcionalidades avançadas e a demanda por capacidade computacional expõe esses veículos a diferentes vulnerabilidades de segurança. Essas vulnerabilidades estão crescendo não apenas em número, mas também em sofisticação. Como no passado as preocupações com a segurança dos VANTs estavam com agressores e sequestradores, agora com o domínio da aplicação civil e inserção na rede, as circunstâncias mudaram. Neste contexto, o objetivo desta dissertação foi avançar o estado da arte através da definição e desenvolvimento de uma arquitetura resiliente para veículos aéreos não tripulados (STUART - reSilient archiTecture to dynamically manage Unmanned aeriAl vehicle networksundeR atTack) que gerencie dinamicamente a rede, mesmo quando submetida a um ataque, integrando métodos de segurança computacional e física. A arquitetura é composta por quadro partes: (1) Sistema de detecção baseado em anomalias, (2) Módulo de triagem, (3) Módulo de tomada de decisão e (4) (5) Módulo de Resiliência. Esta dissertação também investigou a incorporação de segurança física e computacional como um conceito unificado no desenvolvimento de UAVs. A arquitetura desenvolvida foi validada aplicando técnicas específicas em cada uma das partes que compõem a arquitetura. Três testes foram realizados: um com um drone real e dois testes por meio de simulação computacional, compostas por uma estação base e um UAV durante uma missão de transporte de vacinas da COVID-19. Os resultados permitem concluir que a STUART é efetiva na detecção de GPS spoofing e diferentemente de outras arquiteturas encontradas na literatura que focam em missões ou vulnerabilidades específicas, a STUART propõe uma estrutura organizacional de métricas que podem ser agregadas para diferentes contextos e vão desde a detecção de vulnerabilidades, filtragem de falsos-positivos, até a tomada de decisão e mitigação. A sua eficiência foi comprovada através da validação computacional utilizando dados reais de um drone.

SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome. Angewandte Chemie. International Edition, 61 (46) ISSN:0570-0833 ISSN:1433-7851 ISSN:1521-3773

PEER REVIEW REPORT FOR: Pedroso, M. C., Pires, J. T., Malik, A. M., & Pereira, A. J. R. (2021). HCFMUSP: Resilience in response to the COVID-19 pandemic. Revista de Administração Contemporânea, 25(spe), e200245. https://doi.org/10.1590/1982-7849rac2021200245.en HOW TO CITE THIS PEER REVIEW REPORT: Pedroso, M. C., Pires, J. T., Malik, A. M., Pereira, A. J. R., & Araujo, C. (2021). Peer review report for: HCFMUSP: Resilience in response to the COVID-19 pandemic. RAC. Revista de Administração Contemporânea. Zenodo. https://doi.org/10.5281/zenodo.4557887 REVIEWERS: Cláudia Araujo (Universidade Federal do Rio de Janeiro, COPPEAD, Brazil) One of the reviewers chose not to disclose his/her review report.