This paper presents 2D and 3D applications of the Chan-Vese model to heart and trachea segmentation. We improved the multi-phase Chan-Vese model by introducing an iterative method, by choosing an appropriate $L^1$ fidelity term as well as an efficient and prior free initial condition. For 3D applications, the algorithm is parallelized in order to speed up the computations. We provide extensive information on computational details, on the convergence times and on the quality of segmentations obtained. The results of the segmentations are then meshed to be used for finite element simulations. 20 pages
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Recent work has shown that many cellular automata (CA) have configurations whose orbit closures are isomorphic to odometers. We investigate the geometry of the spacetime diagrams of these `odometer configurations'. For boolean linear CA, we exactly determine the positions of the consecutive `gears' of the odometer mechanism in the configuration. Then we characterize and explain the self-similar structure visible in the spacetime diagrams of odometer configurations for two classes of nonlinear CA: ratchet CA and Coven CA. International audience ISBN 978-5-94057-377-7
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In the near future, emergency services within Canada will be supporting new technologies for 9-1-1 call centres and firefighters to learn about an emergency situation. One such technology is drones. To understand the benefits and challenges of using drones within emergency response, we conducted a study with citizens who have called 9-1-1 and firefighters who respond to a range of everyday emergencies. Our results show that drones have numerous benefits to both firefighters and 9-1-1 callers which include context awareness and social support for callers who receive feelings of assurance that help is on the way. Privacy was largely not an issue, though safety issues arose especially for complex uses of drones such as indoor flying. Our results point to opportunities for designing drone systems that help people to develop a sense of trust with emergency response drones, and mitigate privacy and safety concerns with more complex drone systems. International audience
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We present the results of the re-discovery of the decay $B^0 \to \pi^- \ell^+ \nu_\ell$ in 34.6 fb$^{-1}$ of Belle II data using hadronic $B$-tagging via the Full Event Interpretation algorithm. We observe 21 signal events on a background of 155 in a fit to the distribution of the square of the missing mass, $M_{\mathrm{miss}}^2$, with a significance of 5.69$\sigma$, and determine a total branching fraction of (1.58 $\pm$ 0.43$_{\mathrm{stat}}$ $\pm$ 0.07$_{\mathrm{sys}}$) $\times 10^{-4}$.
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In the work using interval mathematics, we develop knowledge for cardinal numbers from the viewpoint of uncertainty analysis. In the finite non-T 1 topological spaces, the inclusion-exclusion formula provide interval estimations for the closure and interior of given sets. This paper introduces a novel approach that combines combinatorial and point-set topology, which leads to a number of results. Among these is the cardinality estimation for the intersection of two open sets that cover a hyperconnected topo-logical space.
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Serpentinites exhumed from mantle wedges are enriched in elements that are mobile at low temperatures, such as As, Sb, Pb, and Sr, based on samples from the Himalayas and the Alps. Such data provide compelling evidence that these fluid-soluble elements were incorporated into the overlying fore-arc mantle wedge from the subducting slab. Thus, serpentinites in the fore-arc mantle act as a sink for water and fluid-soluble elements, insulating the overlying mantle from further hydration.. Downward movement of the serpentinite layer, facilitated by mantle flow, causes transport of these elements to deeper, hotter levels in the mantle. Eventual dehydration of these serpentinites discharges the fluid-soluble elements with water, leading to partial melting of the mantle wedge and accounting for the observed enrichment of these elements in magmas at the volcanic front.
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The use of low optical concentration with planar reflectors represents a relatively simple method for improving solar photovoltaic (PV) specific efficiency. A coupled optical and thermal model was developed to determine the effects on yearly performance of a planar concentrator on array-scale solar PV installations. This model accounts for i) thermal, ii) angle of incidence, iii) reflectivity, and iv) string mismatch loss mechanisms in order to enable informed design of low optical concentration systems. A case study in Canada is presented using the model and the simulation results show that a planar reflector system installed on a traditional crystalline silicon-based PV farm can produce increases in electrical yield from 23-34% compared to a traditional optimized system and thus represents a potential method of achieving practical gains in PV system yield. International audience
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The present study on bibliometric analysis (cumulative) of seven ecology journals reveals that 21,118 authors have contributed 11394 papers during 2003 to 2012. The study examines the year-wise, institution-wise distribution of contributions, relative growth rate and doubling time, authorship patterns, prolific authors, Degree of collaboration, Collaborative co-efficient, etc. The study reveals that multiple authorship was dominant with 78.61% for the study period. The DC and CC were 0.78 and 0.54 respectively. The University Calif. Davis was found to be the top ranked institution contributing 370 papers. International audience
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We investigate the application of integrated micro-combs in RF photonic systems and demonstrate a microwave photonic intensity differentiator based on a Kerr optical comb generated by a compact integrated micro-ring resonator. The on-chip Kerr optical comb is CMOS-compatible and contains a large number of comb lines, which can serve as a high-performance multi-wavelength source for the transversal filter, thus greatly reduce the cost, size, and complexity of the system. The operation principle is theoretically analyzed, and experimental demonstrations of fractional-, first-, second-, and thirdorder differentiation functions based on the principle are presented. International audience
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Les lactones macrocycliques (LM) sont des anthelminthiques (AH) à effet paralysant très utilisés chez les animaux et les humains contre les nématodes parasites. Cependant, leur succès thérapeutique est compromis par la résistance croissante aux LM, qui pourrait être en partie dû aux ABC transporteurs P-glycoprotéines (Pgps) sélectionnés et surexprimés chez les nématodes résistants aux LM. Dans ce travail, nous avons étudié plus précisément la P-glycoprotéine 13 du parasite de petits ruminants, Haemonchus contortus. Son orthologue chez le modèle nématode C. elegans, Cel-Pgp-13, est exprimé dans les amphides, structures qui ont été associées à la sensibilité aux AH chez C. elegans et H. contortus. Pour prédire la capacité des Pgps de nematode à transporter des drogues, incluant des LM et autres AH, nous avons développé un modèle de docking in silico. Nous avons utilisé la structure cristallographique de C. elegans Pgp-1 (Cel-Pgp-1), et nous avons montré la liaison avec une forte affinité de plusieurs ligands décrits comme activateurs de sa fonction ATPasique. Nous avons aussi décrit une forte affinité des LM, et un site spécifique de liaison de ces composés à Cel-Pgp-1. Cette approche représente un outil important pour prédire les interactions entre AH, et pour concevoir rationnellement de nouveaux inhibiteurs compétitifs des Pgps de nématode, dans le but d'améliorer les stratégies thérapeutiques. Sur la base de cette approche, nous avons prédit la structure 3D de Hco-Pgp-13 à partir du cristal de Cel-Pgp-1 afin d'étudier son intéraction avec des substrats potentiels, en particulier les LM. Nous avons trouvé des affinités similaires pour différents composés précédemment testés sur Cel-Pgp-1. In vitro, la mesure de l'activité ATPasique montre que l'actinomycine D est un substrat de Hco-Pgp-13. Nos données démontrent la présence possible d'un domaine de reconnaissance multispécifique sur ce transporteur de parasite. La détermination par immunofluorescence de l'expression de Hco-Pgp-13 a montré une distribution tissulaire large indiquant que Hco-Pgp-13 pourrait jouer un role important dans le transport de substrats endogènes et/ou exogènes. En conclusion, ce travail permet de mieux comprendre le rôle des Pgps de nématodes dans le transport de médicaments AH, tant au niveau de l'organisme modèle C. elegans que du nématode parasite H. contortus. Cette étude suggère la conservation de la fonction de tranporteur ABC multidrogue dans ces espèces. La localisation de Hco-Pgp-13 sur les structures amphidiales, et son éventuelle implication dans la résistance aux médicaments et à la survie de H. contortus à l'exposition à des composés AH, restent à préciser. Macrocyclic lactones (ML) are paralyzing anthelmintics used in animals and humans against parasite nematodes. However, their therapeutic success is compromised by the spread of ML resistance. This might be at least partly due to P-glycoproteins (Pgps) ABC transporters that are selected and overexpressed in ML-resistant nematodes. Deciphering the role of the 10 Pgps expressed in the parasite of small ruminants Haemonchus contortus is thus of major importance to guaranty anthelmintic (AH) efficacy of various drugs. Here we focused on Hco-Pgp-13 due to the expression in the amphids of its closest ortholog in the model nematode C. elegans. Indeed, the amphids represent a putative entry route of drugs to reach AH targets in the nervous system and have been linked to AH susceptibility in C. elegans and H. contortus. In order to predict the capacity of nematode Pgps to transport drugs, including ML and otherAH, we have developed an in silico drug docking model. We have used C. elegans Pgp-1 (Cel-Pgp-1) crystal structure and have showed a high affinity binding of several ligands that have been shown to be activators of its ATPase function. ML were also found to bind with high affinity to Cel-Pgp-1, on a specific binding site. This approach provides a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of nematode Pgps, in order to improve anthelmintic therapeutics. We then predicted a putative 3D structure of Hco-Pgp-13 based on the recently released crystal of Cel-Pgp-1, with which it presented a high homology. This allowed the study of the interaction of Hco-Pgp-13 with potential substrates, in particular ML. We found similar affinities for various drugs previously tested on Cel-Pgp-1, supporting the good homology of these two proteins. Together with in vitro ATPase assay experiments that confirmed the substrate status of actinomycin D, this indicates a possible multispecifc recognition capacity of this parasitic transporter. The determination of Hco-Pgp-13 localization using immunohistochemistry showed a wide tissue expression consistent with a critical role for Hco-Pgp-13 in endogenous and/or exogenous substrate transport. In conclusion, this work provides insights into the role of nematode Pgps in transporting AH drugs, both at the level of the model organism C. elegans and of the parasitic nematode H. contortus. This suggests a high homology of function conserved between ABC tranporters in these species. The localization of such protein on amphidial structures and its possible involvement in drug resistance and survival of H. contortus to exposure to AH compounds remain to be precised.
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This paper presents 2D and 3D applications of the Chan-Vese model to heart and trachea segmentation. We improved the multi-phase Chan-Vese model by introducing an iterative method, by choosing an appropriate $L^1$ fidelity term as well as an efficient and prior free initial condition. For 3D applications, the algorithm is parallelized in order to speed up the computations. We provide extensive information on computational details, on the convergence times and on the quality of segmentations obtained. The results of the segmentations are then meshed to be used for finite element simulations. 20 pages
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Recent work has shown that many cellular automata (CA) have configurations whose orbit closures are isomorphic to odometers. We investigate the geometry of the spacetime diagrams of these `odometer configurations'. For boolean linear CA, we exactly determine the positions of the consecutive `gears' of the odometer mechanism in the configuration. Then we characterize and explain the self-similar structure visible in the spacetime diagrams of odometer configurations for two classes of nonlinear CA: ratchet CA and Coven CA. International audience ISBN 978-5-94057-377-7
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In the near future, emergency services within Canada will be supporting new technologies for 9-1-1 call centres and firefighters to learn about an emergency situation. One such technology is drones. To understand the benefits and challenges of using drones within emergency response, we conducted a study with citizens who have called 9-1-1 and firefighters who respond to a range of everyday emergencies. Our results show that drones have numerous benefits to both firefighters and 9-1-1 callers which include context awareness and social support for callers who receive feelings of assurance that help is on the way. Privacy was largely not an issue, though safety issues arose especially for complex uses of drones such as indoor flying. Our results point to opportunities for designing drone systems that help people to develop a sense of trust with emergency response drones, and mitigate privacy and safety concerns with more complex drone systems. International audience
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