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In this project, we discuss the phenomenon of UAV warfare. By conducting a discourse analysis of two speeches, one conducted by then counterterrorism advisor John Brennan and one by President Barack Obama, we investigate how UAV use is justified. We briefly discuss the historical background and contemporary public opinion in order to contextualize the discourse presented in the two speeches. The discourse analysis is structured in three analytical categories: how are representations of identity are articulated, how the speakers make claims about the future and finally the specific nature of the justifications of UAV use. Finally, we discuss how our empirical findings relate to the discussion of the changing nature of warfare, as well as we present a brief critique of a position in the current UAV debate. Our main argument in this discussion is that UAVs should be discussed within the social, discursive practice they are used, and not regarded merely as technological objects distinct from the context they exist in.

In the paper we describe a new EU infrastructure project dedicated to lexicography. The project is part of the Horizon 2020 program, with a duration of four years (2018-2022). The result of the project will be an infrastructure which will (1) enable efficient access to high quality lexicographic data, and (2) bridge the gap between more advanced and less-resourced scholarly communities working on lexicographic resources. One of the main issues addressed by the project is the fact that current lexicographic resources have different levels of (incompatible) structuring, and are not equally suitable for application in in Natural Language Processing and other fields. The project will therefore develop strategies, tools and standards for extracting, structuring and linking lexicographic resources to enable their inclusion in Linked Open Data and the Semantic Web, as well as their use in the context of digital humanities.

Additional file 2: Table S1. Description of the studies included in the analyses.

Additional file 1: Table S3. Patient and primary breast cancer characteristics per study.

Abstract Background Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous risk prediction model (PredictCBC) by updated follow-up and including additional risk factors. Methods We included data from 207,510 invasive breast cancer patients participating in 23 studies. In total, 8225 CBC events occurred over a median follow-up of 10.2 years. In addition to the previously included risk factors, PredictCBC-2.0 included CHEK2 c.1100delC, a 313 variant polygenic risk score (PRS-313), body mass index (BMI), and parity. Fine and Gray regression was used to fit the model. Calibration and a time-dependent area under the curve (AUC) at 5 and 10 years were assessed to determine the performance of the models. Decision curve analysis was performed to evaluate the net benefit of PredictCBC-2.0 and previous PredictCBC models. Results The discrimination of PredictCBC-2.0 at 10 years was higher than PredictCBC with an AUC of 0.65 (95% prediction intervals (PI) 0.56–0.74) versus 0.63 (95%PI 0.54–0.71). PredictCBC-2.0 was well calibrated with an observed/expected ratio at 10 years of 0.92 (95%PI 0.34–2.54). Decision curve analysis for contralateral preventive mastectomy (CPM) showed the potential clinical utility of PredictCBC-2.0 between thresholds of 4 and 12% 10-year CBC risk for BRCA1/2 mutation carriers and non-carriers. Conclusions Additional genetic information beyond BRCA1/2 germline mutations improved CBC risk prediction and might help tailor clinical decision-making toward CPM or alternative preventive strategies. Identifying patients who benefit from CPM, especially in the general breast cancer population, remains challenging.