• Open Access close
• Open Source close
• Embargo close
• Research data close
• Dataset close
• Clinical Trial close
• Canadian Institutes of Health Resea... close

Droplet digital PCR H3K27M detection validation raw droplet counts. (XLSX 12Â kb)

Additional file 2: Table S2. Prevalence of classified genera in datasets processed by Qiime1 and Qiime2 after excluding OTUs/ASVs with less than 20 reads across each dataset. Table S4. Prevalence of classified genera in datasets processed by Qiime1 and Qiime2 after excluding OTUs/ASVs with less than 20 reads across each dataset and mean relative abundance of less than 0.01%.

Additional file 5: Table S4. EGFR information on LGSC cell lines.

Table S1A. All hydrogen deuterium exchange (HDX) peptide data for experiments examining the global exchange of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. In the Raw Data column, the two time points (0.3s and full) are labelled, and the relative level of HDX is coloured according to the amount of deuterium incorporated, on a blue to red continuum. The data listed for the 0.3s time point are the average of three independent experiments, with SD shown next to all HDX values. In the Normalized to Full Deuteration column, the 0.3s data has been normalised to the full deuteration measurements with the exception of those data (surrounded by black lines) where the full deuteration measurement was lower than 20% deuterium incorporation. The third column denotes the corresponding peptide centroid. Table S1B. All HDX peptide data for experiments examining the complex dynamics of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The two columns represent each state examined (+/- PI4KIIIA) and contain the data for five time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values. Table S1C. All HDX peptide data for experiments examining the dynamics of inhibitor specificity of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The three columns represent each state examined (+/- inhibitor) and contain the data for four time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values.

Additional file 4: Table S3. A. Results for 34 independent ARIC Discovery Meta-Analysis identified mtDNA-CN associated CpGs across all studied cohorts and Validation Meta-Analysis/All Cohort Meta-Analysis. Validation meta-analysis included CHS AA, CHS EA and FHS EA cohorts (P < 0.05 and same direction, bolded cells). All cohort meta-analysis (ARIC AA, ARIC EA, CHS AA, CHS EA and FHS EA) identified 6 validated CpGs (P < 5 × 10–8, shaded cells). B. Results for 23 independent ARIC AA identified CpGs across all studied cohorts. C. Results for 15 independent ARIC EA identified CpGs across all studied cohorts.

Additional file 1: Table S1. The result of stepwise backward elimination. Figure S1. Flow chart for this study of ADNI dataset. The solid outline squares represent subjects that remained. The dash line squares represent excluded subjects. Abbreviations: MCI, Mild cognitive impairment. Figure S2. Correlation between regional SUVR and cortical thickness in the converter group. (A) SUVR of the right middle frontal cortex and medial aspect of the cerebrum; (B) SUVR of the left hippocampus and medial aspect of the cerebrum; (C) SUVR of the right striatum lateral aspect of the cerebrum; (D) SUVR of the left occipital cortex lateral aspect of the cerebrum; (E) Right FBB composite and medial aspect of the cerebrum; (F) Left FBB composite and medial aspect of the cerebrum; (G) Right FBB composite and lateral aspect of the brain; and (H) Left FBB composite and lateral aspect of the brain. FDR correction with p < 0.05, and p value < 0.001. There was no statistical correlation in the non-converter group; thus, only the converter group’s results are shown from (A) to (G). SUVR, standard uptake value ratio; FBB, florbetaben; FDR, false discovery rate.

Spreadsheet of analyte concentrations and metabolite/parent ratios for tamoxifen and its metabolites. (XLSX 10 kb)

Genome-wide predictions of cis-regulatory regions for all six cell types. (ZIP 20400 kb)