Additional file 2. Patterns of gene distribution across mitochondrial and nuclear genomes of the reference species.
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A curated open-access molecular reference database for Drosophila parasitoids (DROP). Identifying Drosophila parasitoids is challenging and poses major impediment to realize the full potential of this model system in studies ranging from molecular mechanisms to food webs, and in biological control of Drosophila suzukii. In DROP, genetic data are linked to voucher specimens and, where possible, the voucher specimens are identified by taxonomists and vetted through direct comparison with primary type material. An updated taxonomic catalogue for the research community is also part of DROP. DROP offers accurate molecular identification and improves cross-referencing between individual studies that we hope will catalyze research on this diverse and fascinating model system. Our effort should also serve as an example for researchers facing similar molecular identification problems in other groups of organisms. Please primarily cite paper which introduces this database. The citation will be added here after publication.
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The modification of GaN with Au nanoparticles is a promising way for manipulating optical properties in optoelectronics and enhancing the sensitivity of GaN-based substrates used in Surface Enhanced Raman Spectroscopy. Ion implantation is an attractive method for the preparation of high-purity metal nanoparticles on the surface or within the bulk of solids, although this process in crystals is not yet fully understood. Here we study the specific stages of Au nanoparticle formation in c-plane GaN crystals implanted with 1.85 MeV Au ions to the fluence range of 1.5×1016, 3×1016, 5×1016 and 7×1016 cm-2. The implanted samples were annealed at 800 °C in an ammonia atmosphere for 20 minutes. The structural and optical properties of the samples were investigated by a combination of Rutherford backscattering spectroscopy in channeling mode (RBS-C), Transmission Electron Microscopy (TEM), Raman spectroscopy, photoluminescence (PL) and diffuse-reflectance spectroscopy (DRS). Rutherford backscattering spectrometry was carried out in the channeling regime (RBS-C) using the 2.8 MeV He ion beam and cumulated charge of 1.69 μC. The collected spectra were used also for calculation of displacement depth profiles. Raman spectra were obtained by the inVia Raman microscope (Renishaw, England) in backscattering geometry with a CCD detector and a DPSS laser (532 nm, 50 mW) with an applied power of 2,5 mW and a 50× magnification objective. High-resolution transmission electron microscopy (HRTEM) and scanning transmission electron microscopy (STEM)and Brieght Field TEM (BF-TEM) images were captured by Fei Tecnai F20 field emission gun transmission electron microscope operated at 200 kV. PL spectroscopy measurements were carried out at 10 K by employing a closed-cycle He refrigerator system and using a 325 nm wavelength He–Cd laser as an excitation source (power density ∼10 W cm-2). The PL spectra were recorded by fiber-optic spectrometers (Ocean Optics HR4000/USB4000). DRS was measured at room temperature (RT) by EVO-600 (Thermo Fisher Scientific, Inc.) UV–Vis spectrophotometer.
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Aim: The current geographical distribution of species largely reflects colonization success after natural long‐distance dispersal or introduction by humans. Plants with selfing ability should have an advantage when establishing on islands where mates and pollinators are limited (Baker's law). However, high percentages of dioecious and self‐incompatible species have been reported for some islands, possibly resulting from post‐colonization evolution. Given that such evolution is less likely to apply to alien species recently introduced to islands by humans, tests of Baker's law on islands need to consider both native and naturalized alien species. Location: Global. Time period: Undefined. Major taxa studied: Angiosperms. Methods: To test whether the colonization of islands is associated with selfing ability (self‐compatibility and autofertility), we combined three comprehensive global databases: one on breeding systems of species, one on island and mainland distributions of native species and one on global naturalization of alien plants. We assigned each of a total of 1,752 species, from 161 angiosperm families, as mainland species, island colonists and/or island endemics (i.e., species that are restricted to islands). To assess potential relationships between island occurrence and selfing ability of species, we used multinomial logistic regressions. Results: We found that species with high selfing ability were slightly more likely to be island colonist than mainland species. However, selfing ability did not increase the likelihood of being an island endemic in contrast to mainland species. Among island colonists, selfing ability did not differ between species on oceanic and on continental islands or between species native to islands and naturalized on islands. Main conclusions: We performed a comprehensive test of Baker's law by considering many angiosperm families, using continuous metrics of self‐compatibility and autofertility and including both native and naturalized species. We provide global evidence that high selfing ability may foster island colonization of angiosperms. Data used to test whether selfing ability benefit island colonization of plantsRazanajatovo_Selfing_ability_and_islands_data.csv
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Abstract Background Myasthenia gravis (MG) is a rare autoimmune disorder with significant clinical implications, including life-threatening myasthenic crises and exacerbations. Understanding real-world treatment patterns, especially associated direct medical costs, is essential for the effective management of healthcare delivery. Methods We conducted a descriptive cohort study using health administrative claims data from the Czech Republic covering more than 1,500 prevalent MG patients. Data were analysed for healthcare resource utilization, medication costs, and hospitalization rates related to MG and its complications. Results Acetylcholine inhibitors and corticosteroids were widely prescribed, with 91.1% and 75.2% of patients receiving them at least once, respectively. Immunosuppressive therapy was given to 45.2% of patients. Myasthenic crises occurred in 2% of patients, with a mean hospitalization cost of 21,020 EUR, while exacerbations occurred in 9.2% of patients, with lower costs (5,951 EUR per hospitalization). Outpatient intravenous immunoglobulin and plasma exchange therapies incurred additional costs of 20,700 EUR and 18,206 EUR per person-year, respectively. The mean total cost per patient-year was 1,271 EUR, with significant cost differences among patients with different treatment patterns. Conclusion This study offers real-world insights into the treatment patterns and associated direct medical costs of MG in the Czech Republic. Myasthenic crises and exacerbations pose considerable cost burdens, while outpatient therapies and common pharmacotherapies are less costly. These findings are vital for healthcare planning, economic evaluation, and resource allocation, potentially leading to enhanced patient care and outcomes.
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Classification dataset used in Kosiba et al. 2020 (10.1093/mnras/staa1723) consisting of candidate clusters in the XCLASS survey Training and testing images and corresponding labels low-z (clusters, 0<z<0.3), hi-z (clusters, z>0.3), nearby galaxy, point source (point, double source, star/AGN), and other (artefact, edge) {"references": ["Kosiba, M., et al. 2020 (10.1093/mnras/staa1723)", "Clerc, N., et al. 2012 (10.1111/j.1365-2966.2012.21153.x)"]}
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This is the 2020 fragment of the GraalVM Compiler Benchmark Results Dataset. Check the other objects in this collection for documentation and scripting support.
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Additional file 2: Figure S1. A. phagocytophilum groEL phylogeny. Figure S2. A. phagocytophilum ankA phylogeny.
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Supporting data for publication: "Electrostatically Driven Polarization Flop and strain-induced Curvature in free-standing Ferroelectric Superlattices" DOI: 10.1002/adma.202106826 This repository contains higher resolution STEM images published in the paper.
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downloads | 13 |
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Additional file 8.
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Additional file 2. Patterns of gene distribution across mitochondrial and nuclear genomes of the reference species.
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A curated open-access molecular reference database for Drosophila parasitoids (DROP). Identifying Drosophila parasitoids is challenging and poses major impediment to realize the full potential of this model system in studies ranging from molecular mechanisms to food webs, and in biological control of Drosophila suzukii. In DROP, genetic data are linked to voucher specimens and, where possible, the voucher specimens are identified by taxonomists and vetted through direct comparison with primary type material. An updated taxonomic catalogue for the research community is also part of DROP. DROP offers accurate molecular identification and improves cross-referencing between individual studies that we hope will catalyze research on this diverse and fascinating model system. Our effort should also serve as an example for researchers facing similar molecular identification problems in other groups of organisms. Please primarily cite paper which introduces this database. The citation will be added here after publication.
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views | 346 | |
downloads | 377 |
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The modification of GaN with Au nanoparticles is a promising way for manipulating optical properties in optoelectronics and enhancing the sensitivity of GaN-based substrates used in Surface Enhanced Raman Spectroscopy. Ion implantation is an attractive method for the preparation of high-purity metal nanoparticles on the surface or within the bulk of solids, although this process in crystals is not yet fully understood. Here we study the specific stages of Au nanoparticle formation in c-plane GaN crystals implanted with 1.85 MeV Au ions to the fluence range of 1.5×1016, 3×1016, 5×1016 and 7×1016 cm-2. The implanted samples were annealed at 800 °C in an ammonia atmosphere for 20 minutes. The structural and optical properties of the samples were investigated by a combination of Rutherford backscattering spectroscopy in channeling mode (RBS-C), Transmission Electron Microscopy (TEM), Raman spectroscopy, photoluminescence (PL) and diffuse-reflectance spectroscopy (DRS). Rutherford backscattering spectrometry was carried out in the channeling regime (RBS-C) using the 2.8 MeV He ion beam and cumulated charge of 1.69 μC. The collected spectra were used also for calculation of displacement depth profiles. Raman spectra were obtained by the inVia Raman microscope (Renishaw, England) in backscattering geometry with a CCD detector and a DPSS laser (532 nm, 50 mW) with an applied power of 2,5 mW and a 50× magnification objective. High-resolution transmission electron microscopy (HRTEM) and scanning transmission electron microscopy (STEM)and Brieght Field TEM (BF-TEM) images were captured by Fei Tecnai F20 field emission gun transmission electron microscope operated at 200 kV. PL spectroscopy measurements were carried out at 10 K by employing a closed-cycle He refrigerator system and using a 325 nm wavelength He–Cd laser as an excitation source (power density ∼10 W cm-2). The PL spectra were recorded by fiber-optic spectrometers (Ocean Optics HR4000/USB4000). DRS was measured at room temperature (RT) by EVO-600 (Thermo Fisher Scientific, Inc.) UV–Vis spectrophotometer.
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Aim: The current geographical distribution of species largely reflects colonization success after natural long‐distance dispersal or introduction by humans. Plants with selfing ability should have an advantage when establishing on islands where mates and pollinators are limited (Baker's law). However, high percentages of dioecious and self‐incompatible species have been reported for some islands, possibly resulting from post‐colonization evolution. Given that such evolution is less likely to apply to alien species recently introduced to islands by humans, tests of Baker's law on islands need to consider both native and naturalized alien species. Location: Global. Time period: Undefined. Major taxa studied: Angiosperms. Methods: To test whether the colonization of islands is associated with selfing ability (self‐compatibility and autofertility), we combined three comprehensive global databases: one on breeding systems of species, one on island and mainland distributions of native species and one on global naturalization of alien plants. We assigned each of a total of 1,752 species, from 161 angiosperm families, as mainland species, island colonists and/or island endemics (i.e., species that are restricted to islands). To assess potential relationships between island occurrence and selfing ability of species, we used multinomial logistic regressions. Results: We found that species with high selfing ability were slightly more likely to be island colonist than mainland species. However, selfing ability did not increase the likelihood of being an island endemic in contrast to mainland species. Among island colonists, selfing ability did not differ between species on oceanic and on continental islands or between species native to islands and naturalized on islands. Main conclusions: We performed a comprehensive test of Baker's law by considering many angiosperm families, using continuous metrics of self‐compatibility and autofertility and including both native and naturalized species. We provide global evidence that high selfing ability may foster island colonization of angiosperms. Data used to test whether selfing ability benefit island colonization of plantsRazanajatovo_Selfing_ability_and_islands_data.csv
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Abstract Background Myasthenia gravis (MG) is a rare autoimmune disorder with significant clinical implications, including life-threatening myasthenic crises and exacerbations. Understanding real-world treatment patterns, especially associated direct medical costs, is essential for the effective management of healthcare delivery. Methods We conducted a descriptive cohort study using health administrative claims data from the Czech Republic covering more than 1,500 prevalent MG patients. Data were analysed for healthcare resource utilization, medication costs, and hospitalization rates related to MG and its complications. Results Acetylcholine inhibitors and corticosteroids were widely prescribed, with 91.1% and 75.2% of patients receiving them at least once, respectively. Immunosuppressive therapy was given to 45.2% of patients. Myasthenic crises occurred in 2% of patients, with a mean hospitalization cost of 21,020 EUR, while exacerbations occurred in 9.2% of patients, with lower costs (5,951 EUR per hospitalization). Outpatient intravenous immunoglobulin and plasma exchange therapies incurred additional costs of 20,700 EUR and 18,206 EUR per person-year, respectively. The mean total cost per patient-year was 1,271 EUR, with significant cost differences among patients with different treatment patterns. Conclusion This study offers real-world insights into the treatment patterns and associated direct medical costs of MG in the Czech Republic. Myasthenic crises and exacerbations pose considerable cost burdens, while outpatient therapies and common pharmacotherapies are less costly. These findings are vital for healthcare planning, economic evaluation, and resource allocation, potentially leading to enhanced patient care and outcomes.
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Classification dataset used in Kosiba et al. 2020 (10.1093/mnras/staa1723) consisting of candidate clusters in the XCLASS survey Training and testing images and corresponding labels low-z (clusters, 0<z<0.3), hi-z (clusters, z>0.3), nearby galaxy, point source (point, double source, star/AGN), and other (artefact, edge) {"references": ["Kosiba, M., et al. 2020 (10.1093/mnras/staa1723)", "Clerc, N., et al. 2012 (10.1111/j.1365-2966.2012.21153.x)"]}
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views | 7 | |
downloads | 2 |
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This is the 2020 fragment of the GraalVM Compiler Benchmark Results Dataset. Check the other objects in this collection for documentation and scripting support.
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views | 15 | |
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Additional file 2: Figure S1. A. phagocytophilum groEL phylogeny. Figure S2. A. phagocytophilum ankA phylogeny.
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Supporting data for publication: "Electrostatically Driven Polarization Flop and strain-induced Curvature in free-standing Ferroelectric Superlattices" DOI: 10.1002/adma.202106826 This repository contains higher resolution STEM images published in the paper.
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views | 33 | |
downloads | 13 |
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Additional file 8.
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