pmid: 31013990
pmc: PMC6514911
Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT),
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citations | 26 | |
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Certain holographic states of matter with a global U(1) symmetry support a sound mode at zero temperature, caused neither by spontaneous symmetry breaking of the global U(1) nor by the emergence of a Fermi surface in the infrared. In this work, we show that such a mode is also found in zero density holographic quantum critical states. We demonstrate that in these states, the appearance of a zero temperature sound mode is the consequence of a mixed `t Hooft anomaly between the global U(1) symmetry and an emergent higher-form symmetry. At non-zero temperatures, the presence of a black hole horizon weakly breaks the emergent symmetry and gaps the collective mode, giving rise to a sharp Drude-like peak in the electric conductivity. A similar gapped mode arises at low temperatures for non-zero densities when the state has an emergent Lorentz symmetry, also originating from an approximate anomalous higher-form symmetry. However, in this case the collective excitation does not survive at zero temperature where, instead, it dissolves into a branch cut. We comment on the relation between our results and the application of the Luttinger theorem to compressible holographic states of matter.
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pmid: 31032043
pmc: PMC6458376
The current study represents a first attempt at examining the neural basis of dramatic acting. While all people play multiple roles in daily life-for example, 'spouse' or 'employee'-these roles are all facets of the 'self' and thus of the first-person (1P) perspective. Compared to such everyday role playing, actors are required to portray
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citations | 18 | |
popularity | Top 10% | |
influence | Average | |
impulse | Top 10% |
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We introduce Sleep, a new Python open-source graphical user interface (GUI) dedicated to visualization, scoring and analyses of sleep data. Among its most prominent features are: (1) Dynamic display of polysomnographic data, spectrogram, hypnogram and topographic maps with several customizable parameters, (2) Implementation of several automatic detection of sleep features such as spindles, K-complexes, slow waves, and rapid eye movements (REM), (3) Implementation of practical signal processing tools such as re-referencing or filtering, and (4) Display of main descriptive statistics including publication-ready tables and figures. The software package supports loading and reading raw EEG data from standard file formats such as European Data Format, in addition to a range of commercial data formats. Most importantly, Sleep is built on top of the VisPy library, which provides GPU-based fast and high-level visualization. As a result, it is capable of efficiently handling and displaying large sleep datasets. Sleep is freely available (http://visbrain.org/sleep) and comes with sample datasets and an extensive documentation. Novel functionalities will continue to be added and open-science community efforts are expected to enhance the capacities of this module.
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Example code for the analysis pipeline used to create the structural template and quantitative myelin water imaging atlases for An atlas for human brain myelin content throughout the adult life span https://www.nature.com/articles/s41598-020-79540-3
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pmid: 28209926
pmc: PMC5361681
Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo. In the present study, we examined short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in a group of older adults (60 yrs) to evaluate the strength of GABA
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citations | 43 | |
popularity | Top 10% | |
influence | Top 10% | |
impulse | Top 10% |
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pmid: 27895941
pmc: PMC5118536
Auditory brain areas undergo reorganization resulting from abnormal sensory input during early postnatal development. This is evident from studies at the cortical level but it remains unclear whether there is reorganization in the auditory midbrain in a species similar to the human, that is, with early hearing onset. We have explored midbrain plasticity in the chinchilla, a precocious species that matches the human in terms of hearing development. Neonatal chinchillas were chronically exposed to a 2 kHz narrowband sound at 70 dB SPL for 4 weeks. Tonotopic maps in inferior colliculus (central nucleus) were defined based on single neuron characteristic frequency. We hypothesized an overrepresentation of the 2 kHz region of the maps. However, we observed a significant decrease in the proportion of neurons dedicated to the 2 kHz octave band and also away from the exposure frequency at 8 kHz. In addition, we report a significant increase in low frequency representation (1 kHz), again a change to tonotopic mapping distant to the 2 kHz region. Thus in a precocious species, tonotopic maps in auditory midbrain are altered following abnormal stimulation during development. However, these changes are more complex than the overrepresentation of exposure related frequency regions that are often reported.
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International audience
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handle: 2434/1036733
This document describes Offline Software and Computing for the Deep Underground Neutrino Experiment (DUNE) experiment, in particular, the conceptual design of the offline computing needed to accomplish its physics goals. Our emphasis in this document is the development of the computing infrastructure needed to acquire, catalog, reconstruct, simulate and analyze the data from the DUNE experiment and its prototypes. In this effort, we concentrate on developing the tools and systems thatfacilitate the development and deployment of advanced algorithms. Rather than prescribing particular algorithms, our goal is to provide resources that are flexible and accessible enough to support creative software solutions as HEP computing evolves and to provide computing that achieves the physics goals of the DUNE experiment.
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pmid: 31013990
pmc: PMC6514911
Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT),
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citations | 26 | |
popularity | Top 10% | |
influence | Average | |
impulse | Top 10% |
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Certain holographic states of matter with a global U(1) symmetry support a sound mode at zero temperature, caused neither by spontaneous symmetry breaking of the global U(1) nor by the emergence of a Fermi surface in the infrared. In this work, we show that such a mode is also found in zero density holographic quantum critical states. We demonstrate that in these states, the appearance of a zero temperature sound mode is the consequence of a mixed `t Hooft anomaly between the global U(1) symmetry and an emergent higher-form symmetry. At non-zero temperatures, the presence of a black hole horizon weakly breaks the emergent symmetry and gaps the collective mode, giving rise to a sharp Drude-like peak in the electric conductivity. A similar gapped mode arises at low temperatures for non-zero densities when the state has an emergent Lorentz symmetry, also originating from an approximate anomalous higher-form symmetry. However, in this case the collective excitation does not survive at zero temperature where, instead, it dissolves into a branch cut. We comment on the relation between our results and the application of the Luttinger theorem to compressible holographic states of matter.
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pmid: 31032043
pmc: PMC6458376
The current study represents a first attempt at examining the neural basis of dramatic acting. While all people play multiple roles in daily life-for example, 'spouse' or 'employee'-these roles are all facets of the 'self' and thus of the first-person (1P) perspective. Compared to such everyday role playing, actors are required to portray
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citations | 18 | |
popularity | Top 10% | |
influence | Average | |
impulse | Top 10% |
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We introduce Sleep, a new Python open-source graphical user interface (GUI) dedicated to visualization, scoring and analyses of sleep data. Among its most prominent features are: (1) Dynamic display of polysomnographic data, spectrogram, hypnogram and topographic maps with several customizable parameters, (2) Implementation of several automatic detection of sleep features such as spindles, K-complexes, slow waves, and rapid eye movements (REM), (3) Implementation of practical signal processing tools such as re-referencing or filtering, and (4) Display of main descriptive statistics including publication-ready tables and figures. The software package supports loading and reading raw EEG data from standard file formats such as European Data Format, in addition to a range of commercial data formats. Most importantly, Sleep is built on top of the VisPy library, which provides GPU-based fast and high-level visualization. As a result, it is capable of efficiently handling and displaying large sleep datasets. Sleep is freely available (http://visbrain.org/sleep) and comes with sample datasets and an extensive documentation. Novel functionalities will continue to be added and open-science community efforts are expected to enhance the capacities of this module.