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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yuanyuan Liao; Guolin Zhou; Jiuxing Liang; Xiangmin Zhang; +2 Authors

    Sleep is indispensable for humans to maintain normal life activities. Sex and individual differences in sleep patterns and quality of sleep cannot be ignored. Nevertheless, the overall population generalities and sex- or individual- differences in cerebral cortical functional connectivity (FC) during sleep have not been well described. Here, we evaluated the characteristic patterns of FC based on whole-night sleep electroencephalography (EEG) recordings. An improved weighted phase lag index (WPLI) algorithm was applied to obtain the FC in delta (0.5-4Hz), theta (4-8Hz), alpha (8-12Hz) and beta band (12-32Hz). FC strength, short-term stability and inter-regional imbalance of FC were studied. We found that the variations in FC-related parameters among sleep stages had overall population commonalities, and these parameters also showed stage- and frequency band-dependent sex differences. With the deepening of no-rapid eye movement (NREM), increased delta and beta FC strength were observed. Rapid eye movement (REM) showed weaker FC strength, higher FC stability, and higher anterior-posterior FC anisotropy than NREM in beta band. Meanwhile, females exhibited higher sleep EEG synchronization and higher delta FC stability in deep NREM sleep than males. Moreover, the dominant hemisphere in terms of FC did not show group generality or stage- and frequency-dependence. Our results add to the understanding of sleep staging function and may provide clues to sex differences in sleep patterns and quality as well as the prevalence and clinical manifestations of sleep-related illness. Short-term stability offers a new perspective in analyzing FC, which cannot be ignored.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ IEEE Accessarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    IEEE Access
    Article . 2019 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    IEEE Access
    Journal . Article . 2019
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    IEEE Access
    Article
    License: CC BY
    Data sources: UnpayWall
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    DOAJ
    Article . 2019
    Data sources: DOAJ
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ IEEE Accessarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      IEEE Access
      Article . 2019 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      IEEE Access
      Journal . Article . 2019
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      IEEE Access
      Article
      License: CC BY
      Data sources: UnpayWall
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      DOAJ
      Article . 2019
      Data sources: DOAJ
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Eloisa Bonfa; Eduardo Ferreira Borba; Rui Toledo Barros; Leonardo de Abreu Testagrossa; +4 Authors

    The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of lupus nephritis (LN). Seventy-eight consecutive patients with systemic lupus erythematosus (ACR criteria) and active nephritis who underwent renal biopsy from 1999 to 2004 and with available frozen serum sample obtained at the time of biopsy were selected. aCT was measured by ELISA, and anti-dsDNA was measured by indirect immunofluorescence (IIF) and by ELISA. All renal biopsies were revised in a blinded manner by the same expert renal pathologist. Charts were extensively reviewed for demographic and renal features obtained at the time of biopsy. The prevalence of aCT (≥20 U) was 59% with a mean titer of 74.3 ± 38.7U. Both aCT-positive and aCT-negative groups of patients had similar age, gender distribution, duration of lupus, and duration of renal disease. Anti-dsDNA was detected by IIF in 29.5% and by ELISA in 42.3% of the patients. Concomitant presence of both antibodies was observed in 63% (29/46) [anti-dsDNA by ELISA] and 45.6% (21/46) [anti-dsDNA by IIF] of the patients. Lower serum levels of C3 (73% vs. 40%, P = 0.0058) and C4 (82% vs. 46.7%, P = 0.0021) were more commonly observed in aCT ≥ 20 U patients compared to the aCT-negative group. It is important to note that the use of a higher cut-off value (≥40 U) for aCT test revealed a predominance of class IV LN (58% vs. 33%, P = 0.039) in aCT ≥ 40 U compared to aCT < 40 U group. The mean levels of proteinuria, serum albumin, and creatinine were markedly altered but were comparable in both groups (P ≥ 0.05). One fourth (26.3%) of the 19 patients with class IV LN and aCT ≥ 40 U had no detectable anti-dsDNA (ELISA). These data suggest that high-titer aCT seems to be a valuable biomarker for proliferative class IV of LN.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Clinical Rheumatolog...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Clinical Rheumatology
    Article . 2008 . Peer-reviewed
    License: Springer TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Clinical Rheumatolog...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Clinical Rheumatology
      Article . 2008 . Peer-reviewed
      License: Springer TDM
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Jianjun Meng; Xiaohai Xiong; Huabin Xing; Hushan Jin; +4 Authors

    We report the latest development in tunable transmitter optical sub-assembly (TOSA) and small form-factor pluggable (SFP) transceivers based on simple and compact V-cavity laser (VCL), aiming for low-cost deployment in metro, access, and data center networks. The VCL employs a half-wave coupler to achieve high side-mode suppression ratio (SMSR) and the Vernier effect to achieve a wide wavelength tuning range. Full C-band tuning from 1529.55- to 1566.31-nm with SMSR above 36 dB is demonstrated. Since the laser does not involve any grating or epitaxial regrowth, and has a simple tuning algorithm, it allows simpler processes for fabrication and testing as compared with other widely tunable laser structures. Compact TOSAs and SFP transceiver modules have been developed for full C-band tuning with up to 93 channels at 50 GHz spacing. Transmission experiments are carried out for direct modulation with data rates from 2.5 to 8.5 Gbps. The results of reliability tests of the modules are also presented.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE Photonics Techn...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    IEEE Photonics Technology Letters
    Article . 2017 . Peer-reviewed
    License: IEEE Copyright
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    21
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE Photonics Techn...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      IEEE Photonics Technology Letters
      Article . 2017 . Peer-reviewed
      License: IEEE Copyright
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Yuxuan Ren; Qing Luo; Shaojie Zhuo; Yuanan Hu; +3 Authors

    Atmospheric coarse particulate matter (PM

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Chemospherearrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Chemosphere
    Article . 2021 . Peer-reviewed
    License: Elsevier TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Chemospherearrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Chemosphere
      Article . 2021 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yanjing Zhu; Ruiqi Huang; Deheng Wang; Liqun Yu; +8 Authors

    Alzheimer's disease (AD) is a typical neurodegenerative disease that leads to irreversible neuronal degeneration, and effective treatment remains elusive due to the unclear mechanism. We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241 (EVs-AM1241) to protect against neurodegenerative progression and neuronal function in AD model mice. According to the results, EVs-AM1241 were successfully constructed and exhibited better bioavailability and therapeutic effects than bare AM1241. The Morris water maze (MWM) and fear conditioning tests revealed that the learning and memory of EVs-AM1241-treated model mice were significantly improved.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Asian Journal of Pha...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Asian Journal of Pharmaceutical Sciences
    Article . 2023 . Peer-reviewed
    License: CC BY NC ND
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Asian Journal of Pha...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Asian Journal of Pharmaceutical Sciences
      Article . 2023 . Peer-reviewed
      License: CC BY NC ND
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Eric F. May; Matthew G. Hopkins; Gabriele Raabe; Catherine C. Sampson; +1 Authors

    Abstract The introduction of new refrigerants based on HFO compounds such as trans-1,3,3,3-tetrafluoropropene (R1234ze(E)) and 2,3,3,3-tetrafluoropropene (R1234yf) requires information on their dielectric properties to understand their interactions with electrically-live parts of thermal systems. Furthermore, the application of these HFOs as components in blends gives rise to the need for reliable approaches for predicting the dielectric properties of such mixtures. We report experimental data for the dielectric permittivity and polarization of the mixtures (0.50 R1234yf + 0.50 R1234ze(E)) and (0.89 R1234yf + 0.11 R1234ze(E)) over a temperature range from (250 to 366) K and pressure range from (0.6 to 10.0) MPa. The experimental data are used to test the applicability of a semi-theoretical correlation for the molar polarizability of the pure fluids, presented in our earlier work, combined with a mixing rule from the literature to estimate the dielectric properties of the mixtures. Additionally, we analyse the performance of a hybrid modelling approach for the dielectric permittivity, which is based on molecular simulation with a correction to account for the effect of each molecule’s electronic polarization. Two different approaches to calculating the correction term are investigated, either incorporating experimental molecular polarizability data or data from ab initio simulations. The comparison shows that the empirical mixing rule approach decreases in accuracy as mixing effects become increasingly pronounced, whereas the molecular simulations describe the mixtures as well as they do the pure fluids. However, the molecular simulations are limited by their under-prediction of the dielectric permittivity of R1234yf at liquid densities above 9.5 kmol∙m−3.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ The Journal of Chemi...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    The Journal of Chemical Thermodynamics
    Article . 2020 . Peer-reviewed
    License: Elsevier TDM
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ The Journal of Chemi...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      The Journal of Chemical Thermodynamics
      Article . 2020 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yongming Li; Ang Luo; Xi Chen; Leiming Cheng; +2 Authors

    Distributions of pore pressure and water saturation in matrix around fractures after hydraulic fracturing and shut-in period will impact the shale gas well production significantly. However, the influences of hydraulic fracturing and shut-in period on pore pressure and water saturation are not considered in the classical reservoir simulations. In this work, the embedded discrete fracture model (EDFM), which is convenient to be coupled with an existing reservoir simulator with high computational efficiency, was employed to simulate the hydraulic fracture propagation coupled with matrix flow. Then, we developed a model for simulating the integration process of hydraulic fracturing, shut-in period, and well production based on the dual media theory. Distributions of pore pressure and water saturation varying in different periods and the production decline of shale gas well were obtained through the integrated simulation model. The calculation result was validated by the field bottom hole pressure data of a shale gas well in Sichuan Province, China. Simulation results show that the variation of bottom hole pressure is not smooth during the fracture propagation process because the initiations of different fractures are not simultaneous. The fracturing fluid flow-back rate of shale gas well is much lower than that of conventional reservoirs. There is still a large amount of fracturing fluid retained in micro-fracture systems and matrix of shale after production. It is also found that the permeability of the micro-fracture system determines the drop rate of bottom hole pressure and the size of stimulated reservoir volume (SRV) determines the decrease amplitude of bottom hole pressure.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Energy ...arrow_drop_down
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    Frontiers in Energy Research
    Article . 2022
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    Frontiers in Energy Research
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      Frontiers in Energy Research
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    Authors: Bahareh Nateghi; Kostiantyn V. Domasevitch; Roman Bulánek; Christoph Janiak; +1 Authors

    A new porous coordination polymer (PCP/MOF), ZRTE-10, based on a tetrahedral 1,3,5,7-tetra(carboxyphenyl)-benzene ligand (H4L4) was synthesized using formic or acetic acids as modulators. The low symmetry (C2/c) framework, [Zr-6(mu(3)-O)(4)(mu(3)-OH )(4)(L-4)(HL4)(2)(OH)(2)(H2O)(2)], is built upon a rare 10-connected Zr-6 cluster. Two-thirds of the ligands bear one nondeprotonated carboxy group, and the framework has a complex trinodal 3,4,10-c, {4(14).6(24).8(7)}{4(3)}(2){4(5).6}, underlying net. Supercritical CO2 drying and mild degassing at 120 degrees C yielded a porous material with S-BET = 1190 m(2) g(-1). When heated up to similar to 200 degrees C, ZRTE-10 converts to another crystalline framework, ZRTE-11. The latter was identified to be identical to the expected fluorite (flu) observed previously for other tetrahedral ligands. The high symmetry (I4/m) framework is built upon 8-connected Zr-6 clusters and has a formula of [Zr-6(mu(3)-O)(4)(mu(3)-OH )(4)(L-4)(2)]. The complicated trinodal network of ZRTE-10 and the simple flu net in ZRTE-11 are topologically interrelated via the operation of the merging of two neighbor three-connected nodes to one fourconnected one. The thermally induced conversion of ZRTE-10 proceeds with expulsion of one ligand per Zr-6 node in the pores of the framework, resulting in a relatively low S-BET = 585 m(2) g(-1) for the activated H4L4@ZRTE-11. A mixed ligand approach for ZRTE-10,11 was attempted using 1,3,5-tetra(carboxyphenyl)benzene (H3L3), which is a truncated analog of H4L4 with one missing branch. The monocrystalline sample of ZRTE-10 obtained in small yields demonstrated only minor inclusion of H3L3. However, the high-yielding (similar to 80%) procedure with HCl as a modulator allows near proportional incorporation of the ligands. The formed materials are semiamorphous with powder XRDs intermediary between pure ZRTE-10 and -11. Thermal treatment of the semiamorphous materials increases their crystallinity and allows S-BET = 400-550 m(2) g(-1) surface areas to be reached for pure H4L4 and H3L3 or their mixture alike. The approach proposes a viewpoint on the H3L3 trifunctional ligand as a model of a ligand platform, suitable for bearing a large functionality on the fourth "truncated" branch. The significance of ZRTE-10 as a material for postsynthetic introduction of metal-based cluster functionality and as a model of functionality encapsulation, an alternative to the ship-in-the-bottle method, is discussed. Nový porézní koordinační polymer (PCP/MOF), ZRTE-10, založený na tetraedrálním 1.3.5.7-tetra(karboxyfenyl)benzenovém ligandu H4L4) byl syntetizován a sledován během tepelné transformace metodou XRD.

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    Inorganic Chemistry
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    Inorganic Chemistry
    Article . 2019 . Peer-reviewed
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      Inorganic Chemistry
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      Inorganic Chemistry
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Pengfei Sun; Kai Chen; Hua Zhang; Wei Huang; +5 Authors

    Fluorescence imaging (FI) in the second near-infrared optical window (NIR-II, 1000-1700 nm) has received increasing focus due to its capacity of high spatiotemporal resolution, rapid real-time imaging, and deep penetration depth. In addition, D-A-D-based organic small molecules have also attracted wide attention due to their designed chemical structure and rapid renal metabolism. However, most of the fluorescent cores were based on benzobisthiadiazole (BBTD) and 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ACS Applied Bio Mate...arrow_drop_down
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    ACS Applied Bio Materials
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      ACS Applied Bio Materials
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    Authors: Keyu Zhu; Miaomiao Li; Haibin Wu; Deyun Zhang; +20 Authors

    Abstract Wheat powdery mildew, caused by Blumeria graminis f. sp. tritici ( Bgt ), is a globally devastating disease. Wild emmer wheat ( Triticum turgidum var. dicoccoides ) is a valuable genetic resource for improving disease resistance in common wheat. A powdery mildew resistance gene was transferred to hexaploid wheat line WE74 from wild emmer accession G-748-M. Genetic analysis revealed that the powdery mildew resistance in WE74 is controlled by a single dominant gene, herein temporarily designated MlWE74 . Bulked segregant analysis (BSA) and molecular mapping delimited MlWE74 to the terminal region of chromosome 2BS flanking by markers WGGBD412 and WGGBH346 within a genetic interval of 0.25 cM and corresponding to 799.9 kb genomic region in the Zavitan reference sequence. Sequence annotation revealed two phosphoglycerate mutase-like genes, an alpha/beta-hydrolases gene, and five NBS-LRR disease resistance genes that could serve as candidates for map-based cloning of MlWE74 . The geographical location analysis indicated that MlWE74 is mainly distributed in Rosh Pinna and Amirim regions, in the northern part of Israel, where environmental conditions are favorable to the occurrence of powdery mildew. Moreover, the co-segregated marker WGGBD425 is helpful in marker-assisted transfer of MlWE74 into elite cultivars.

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    https://doi.org/10.21203/rs.3....
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    Theoretical and Applied Genetics
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      https://doi.org/10.21203/rs.3....
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      Theoretical and Applied Genetics
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yuanyuan Liao; Guolin Zhou; Jiuxing Liang; Xiangmin Zhang; +2 Authors

    Sleep is indispensable for humans to maintain normal life activities. Sex and individual differences in sleep patterns and quality of sleep cannot be ignored. Nevertheless, the overall population generalities and sex- or individual- differences in cerebral cortical functional connectivity (FC) during sleep have not been well described. Here, we evaluated the characteristic patterns of FC based on whole-night sleep electroencephalography (EEG) recordings. An improved weighted phase lag index (WPLI) algorithm was applied to obtain the FC in delta (0.5-4Hz), theta (4-8Hz), alpha (8-12Hz) and beta band (12-32Hz). FC strength, short-term stability and inter-regional imbalance of FC were studied. We found that the variations in FC-related parameters among sleep stages had overall population commonalities, and these parameters also showed stage- and frequency band-dependent sex differences. With the deepening of no-rapid eye movement (NREM), increased delta and beta FC strength were observed. Rapid eye movement (REM) showed weaker FC strength, higher FC stability, and higher anterior-posterior FC anisotropy than NREM in beta band. Meanwhile, females exhibited higher sleep EEG synchronization and higher delta FC stability in deep NREM sleep than males. Moreover, the dominant hemisphere in terms of FC did not show group generality or stage- and frequency-dependence. Our results add to the understanding of sleep staging function and may provide clues to sex differences in sleep patterns and quality as well as the prevalence and clinical manifestations of sleep-related illness. Short-term stability offers a new perspective in analyzing FC, which cannot be ignored.

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    IEEE Access
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      IEEE Access
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Eloisa Bonfa; Eduardo Ferreira Borba; Rui Toledo Barros; Leonardo de Abreu Testagrossa; +4 Authors

    The antichromatin antibody (aCT) has been described as a useful marker for lupus nephropathy. The relevance of its nephritogenic potential may be appropriately evaluated in the context of renal histopathology. Therefore, the present study investigated the relationship of aCT with a particular histopathologic class of lupus nephritis (LN). Seventy-eight consecutive patients with systemic lupus erythematosus (ACR criteria) and active nephritis who underwent renal biopsy from 1999 to 2004 and with available frozen serum sample obtained at the time of biopsy were selected. aCT was measured by ELISA, and anti-dsDNA was measured by indirect immunofluorescence (IIF) and by ELISA. All renal biopsies were revised in a blinded manner by the same expert renal pathologist. Charts were extensively reviewed for demographic and renal features obtained at the time of biopsy. The prevalence of aCT (≥20 U) was 59% with a mean titer of 74.3 ± 38.7U. Both aCT-positive and aCT-negative groups of patients had similar age, gender distribution, duration of lupus, and duration of renal disease. Anti-dsDNA was detected by IIF in 29.5% and by ELISA in 42.3% of the patients. Concomitant presence of both antibodies was observed in 63% (29/46) [anti-dsDNA by ELISA] and 45.6% (21/46) [anti-dsDNA by IIF] of the patients. Lower serum levels of C3 (73% vs. 40%, P = 0.0058) and C4 (82% vs. 46.7%, P = 0.0021) were more commonly observed in aCT ≥ 20 U patients compared to the aCT-negative group. It is important to note that the use of a higher cut-off value (≥40 U) for aCT test revealed a predominance of class IV LN (58% vs. 33%, P = 0.039) in aCT ≥ 40 U compared to aCT < 40 U group. The mean levels of proteinuria, serum albumin, and creatinine were markedly altered but were comparable in both groups (P ≥ 0.05). One fourth (26.3%) of the 19 patients with class IV LN and aCT ≥ 40 U had no detectable anti-dsDNA (ELISA). These data suggest that high-titer aCT seems to be a valuable biomarker for proliferative class IV of LN.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Clinical Rheumatolog...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Clinical Rheumatology
    Article . 2008 . Peer-reviewed
    License: Springer TDM
    Data sources: Crossref
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Clinical Rheumatolog...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Clinical Rheumatology
      Article . 2008 . Peer-reviewed
      License: Springer TDM
      Data sources: Crossref
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Jianjun Meng; Xiaohai Xiong; Huabin Xing; Hushan Jin; +4 Authors

    We report the latest development in tunable transmitter optical sub-assembly (TOSA) and small form-factor pluggable (SFP) transceivers based on simple and compact V-cavity laser (VCL), aiming for low-cost deployment in metro, access, and data center networks. The VCL employs a half-wave coupler to achieve high side-mode suppression ratio (SMSR) and the Vernier effect to achieve a wide wavelength tuning range. Full C-band tuning from 1529.55- to 1566.31-nm with SMSR above 36 dB is demonstrated. Since the laser does not involve any grating or epitaxial regrowth, and has a simple tuning algorithm, it allows simpler processes for fabrication and testing as compared with other widely tunable laser structures. Compact TOSAs and SFP transceiver modules have been developed for full C-band tuning with up to 93 channels at 50 GHz spacing. Transmission experiments are carried out for direct modulation with data rates from 2.5 to 8.5 Gbps. The results of reliability tests of the modules are also presented.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE Photonics Techn...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    IEEE Photonics Technology Letters
    Article . 2017 . Peer-reviewed
    License: IEEE Copyright
    Data sources: Crossref
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