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  • Open Access English
    Authors: 
    Lue, Tom F.; Garcia, Maurice;
    Publisher: AME Publishing Company
  • Open Access English
    Authors: 
    Goldstein, Gisèle Ruiz; Goldstein, Jerome A.; Jia, Wenyao;
    Publisher: Khayyam Publishing, Inc.

    Of concern is a quantum mechanical system having $N_{1}$ (resp. $N_{2}$) spin up (resp. spin down) electrons, in the presence of a potential $V$ and a magnetic field $B.$ When the Fermi-Amaldi correction is incorporated into the Thomas-Fermi energy functional, convexity is lost and the computation of the ground state spin up and down electron densities becomes nontrivial. We discuss the existence of these densities and various approximation procedures for them, via variational calculus, differential equations, and numerical procedures.

  • Open Access English
    Authors: 
    KARATAŞ, Neva;
    Publisher: Volkan OKATAN

    Wild edible fruits have been gained more popularity more recently due to their higher human health related compounds and unique aroma characteristics. The genus Rosa includes over 30 species and among them Rosa pimpinellifolia has distinct plant and fruit traits and the studies on this specie in literature is very limited. In this study, some fruit morphological and nutritional characteristics of six R. pimpinellifolia plants naturally grown in Ilica district of Erzurum province have been studied. Results exhibited that genotypes differed each other for most of the morphological and nutritional characteristics. The six genotypes showed fruit weights and flesh ratio between 1.88-2.21 g and 81.10-90.83%, respectively. Total anthocyanin, vitamin C and total phenolic content of the six R. pimpinellifolia genotypes ranged from 3.74-5.02 mg cyanidin-3-glucoside, 37-53 mg per 100 g fresh weight, 1018-1407 mg gallic acid equivalent (GAE) per 100 g fresh weight, respectively. Antioxidant activity was found between 10.11-13.86 μmol Fe (II)/g fresh weight among genotypes. Results indicate potential use of fruits of R. pimpinellifolia in food industry in future.

  • Publication . Article . 1977
    Open Access English
    Authors: 
    Zalkin, Allan;
    Publisher: eScholarship, University of California
    Country: United States
  • Publication . Article . 2014
    Open Access English
    Authors: 
    Goldberg, Merryl; Smith, Virginia; Walker, Elaine;
    Publisher: eScholarship, University of California
    Country: United States

    This contribution provides an overview of the articles featured in the 10th volume of the Journal for Learning through the Arts.

  • Publication . Book . 2020
    Open Access English
    Publisher: Presses universitaires de Rennes

    Territorial and military organization of the Portuguese colony of Angola in the 17th century. Mathieu Mogo Demaret At the end of the 16th century and in the beginning of the 17th century, in the context of the development of the transatlantic slave trade, Angola played a prominent role in the political plans of Portugal and the United-Provinces for the South Atlantic. One particularity of the region of Luanda and its hinterland lies in the fact that the European presence was not limited to th...

  • Publication . Other literature type . 1920
    Open Access English
  • Publication . Other literature type . 1947
    Open Access English
    Authors: 
    Robertson, P. A. M.;
  • Open Access English
    Authors: 
    Powell, Sara Kathleen; Rivera-Soto, Ricardo; Gray, Steven James;

    Over the last five years, the number of clinical trials involving AAV (adeno-associated virus) and lentiviral vectors continue to increase by about 150 trials each year. For continued success, AAV and lentiviral expression cassettes need to be designed to meet each disease's specific needs. This review discusses how viral vector expression cassettes can be engineered with elements to enhance target specificity and increase transgene expression. The key differences relating to target specificity between ubiquitous and tissue-specific promoters are discussed, as well as how endogenous miRNAs and their target sequences have been used to restrict transgene expression. Specifically, relevant studies indicating how cis-acting elements such as introns, WPRE, polyadenylation signals, and the CMV enhancer are highlighted to show their utility for enhancing transgene expression in gene therapy applications. All discussion bears in mind that expression cassettes have space constraints. In conclusion, this review can serve as a menu of vector genome design elements and their cost in terms of space to thoughtfully engineer viral vectors for gene therapy.

  • Publication . Article . 2012
    Open Access English
    Authors: 
    Liu, Qiang; Wang, Hong-Gang;
    Publisher: Landes Bioscience
    Project: NIH | POSTTRANSLATIONAL MODIFIC... (5R01CA082197-04)

    Deregulated apoptosis is a hallmark of cancer, and the B-cell lymphoma-2 (Bcl-2) family of proteins is pivotal to mediating the intrinsic pathway of this process. Recent advances have yielded both pan-Bcl-2 small molecule inhibitors (SMIs) that inhibit both the Bcl-2 and the Mcl-1 arm of the Bcl-2 family anti-apoptotic proteins, as well as selective SMIs to differentially target the two arms. Of these SMIs, ABT-263 (navitoclax), AT-101 [(-)-gossypol], and obatoclax (GX15-070) are currently in clinical trials for multiple cancers. While pan-Bcl-2 inhibitors such as AT-101 and obatoclax can be more toxic for inhibiting all members of the anti-apoptotic Bcl-2 family of proteins, resistance can quickly develop for ABT-263, a selective Bcl-2 inhibitor. In this article, we discuss the current status of Bcl-2 family SMIs in preclinical and clinical development. As Mcl-1 upregulation is a major mechanism of ABT-263 resistance, Mcl-1-specific inhibitors are expected to be efficacious both in combination/sequential treatments and as a single agent against cancers resistant to ABT-263. 

Advanced search in
Research products
arrow_drop_down
Searching FieldsTerms
Any field
arrow_drop_down
includes
arrow_drop_down
Include:
17,501,894 Research products, page 1 of 1,750,190
  • Open Access English
    Authors: 
    Lue, Tom F.; Garcia, Maurice;
    Publisher: AME Publishing Company
  • Open Access English
    Authors: 
    Goldstein, Gisèle Ruiz; Goldstein, Jerome A.; Jia, Wenyao;
    Publisher: Khayyam Publishing, Inc.

    Of concern is a quantum mechanical system having $N_{1}$ (resp. $N_{2}$) spin up (resp. spin down) electrons, in the presence of a potential $V$ and a magnetic field $B.$ When the Fermi-Amaldi correction is incorporated into the Thomas-Fermi energy functional, convexity is lost and the computation of the ground state spin up and down electron densities becomes nontrivial. We discuss the existence of these densities and various approximation procedures for them, via variational calculus, differential equations, and numerical procedures.

  • Open Access English
    Authors: 
    KARATAŞ, Neva;
    Publisher: Volkan OKATAN

    Wild edible fruits have been gained more popularity more recently due to their higher human health related compounds and unique aroma characteristics. The genus Rosa includes over 30 species and among them Rosa pimpinellifolia has distinct plant and fruit traits and the studies on this specie in literature is very limited. In this study, some fruit morphological and nutritional characteristics of six R. pimpinellifolia plants naturally grown in Ilica district of Erzurum province have been studied. Results exhibited that genotypes differed each other for most of the morphological and nutritional characteristics. The six genotypes showed fruit weights and flesh ratio between 1.88-2.21 g and 81.10-90.83%, respectively. Total anthocyanin, vitamin C and total phenolic content of the six R. pimpinellifolia genotypes ranged from 3.74-5.02 mg cyanidin-3-glucoside, 37-53 mg per 100 g fresh weight, 1018-1407 mg gallic acid equivalent (GAE) per 100 g fresh weight, respectively. Antioxidant activity was found between 10.11-13.86 μmol Fe (II)/g fresh weight among genotypes. Results indicate potential use of fruits of R. pimpinellifolia in food industry in future.

  • Publication . Article . 1977
    Open Access English
    Authors: 
    Zalkin, Allan;
    Publisher: eScholarship, University of California
    Country: United States
  • Publication . Article . 2014
    Open Access English
    Authors: 
    Goldberg, Merryl; Smith, Virginia; Walker, Elaine;
    Publisher: eScholarship, University of California
    Country: United States

    This contribution provides an overview of the articles featured in the 10th volume of the Journal for Learning through the Arts.

  • Publication . Book . 2020
    Open Access English
    Publisher: Presses universitaires de Rennes

    Territorial and military organization of the Portuguese colony of Angola in the 17th century. Mathieu Mogo Demaret At the end of the 16th century and in the beginning of the 17th century, in the context of the development of the transatlantic slave trade, Angola played a prominent role in the political plans of Portugal and the United-Provinces for the South Atlantic. One particularity of the region of Luanda and its hinterland lies in the fact that the European presence was not limited to th...

  • Publication . Other literature type . 1920
    Open Access English
  • Publication . Other literature type . 1947
    Open Access English
    Authors: 
    Robertson, P. A. M.;
  • Open Access English
    Authors: 
    Powell, Sara Kathleen; Rivera-Soto, Ricardo; Gray, Steven James;

    Over the last five years, the number of clinical trials involving AAV (adeno-associated virus) and lentiviral vectors continue to increase by about 150 trials each year. For continued success, AAV and lentiviral expression cassettes need to be designed to meet each disease's specific needs. This review discusses how viral vector expression cassettes can be engineered with elements to enhance target specificity and increase transgene expression. The key differences relating to target specificity between ubiquitous and tissue-specific promoters are discussed, as well as how endogenous miRNAs and their target sequences have been used to restrict transgene expression. Specifically, relevant studies indicating how cis-acting elements such as introns, WPRE, polyadenylation signals, and the CMV enhancer are highlighted to show their utility for enhancing transgene expression in gene therapy applications. All discussion bears in mind that expression cassettes have space constraints. In conclusion, this review can serve as a menu of vector genome design elements and their cost in terms of space to thoughtfully engineer viral vectors for gene therapy.

  • Publication . Article . 2012
    Open Access English
    Authors: 
    Liu, Qiang; Wang, Hong-Gang;
    Publisher: Landes Bioscience
    Project: NIH | POSTTRANSLATIONAL MODIFIC... (5R01CA082197-04)

    Deregulated apoptosis is a hallmark of cancer, and the B-cell lymphoma-2 (Bcl-2) family of proteins is pivotal to mediating the intrinsic pathway of this process. Recent advances have yielded both pan-Bcl-2 small molecule inhibitors (SMIs) that inhibit both the Bcl-2 and the Mcl-1 arm of the Bcl-2 family anti-apoptotic proteins, as well as selective SMIs to differentially target the two arms. Of these SMIs, ABT-263 (navitoclax), AT-101 [(-)-gossypol], and obatoclax (GX15-070) are currently in clinical trials for multiple cancers. While pan-Bcl-2 inhibitors such as AT-101 and obatoclax can be more toxic for inhibiting all members of the anti-apoptotic Bcl-2 family of proteins, resistance can quickly develop for ABT-263, a selective Bcl-2 inhibitor. In this article, we discuss the current status of Bcl-2 family SMIs in preclinical and clinical development. As Mcl-1 upregulation is a major mechanism of ABT-263 resistance, Mcl-1-specific inhibitors are expected to be efficacious both in combination/sequential treatments and as a single agent against cancers resistant to ABT-263. 

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