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1,091 research outcomes, page 1 of 110
  • publication . Article . 2016
    Open Access English
    Authors:
    Nicholas G. Dowell; E. Cooper; Jeremy Tibble; Valerie Voon; Hugo D. Critchley; Mara Cercignani; Neil A. Harrison;
    Publisher: Elsevier
    Project: WT

    BACKGROUND\ud \ud Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used clinically for hepatitis C treatment. Though effective, IFN-α induces marked behavioral changes that, when severe, can appear indistinguishable from major depression. Curious...

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  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Toru Suzuki; Maki Asami; Sanjay G. Patel; Louis Y. P. Luk; Yu-Hsuan Tsai; Anthony C.F. Perry;
    Publisher: Nature Publishing Group
    Project: WT | Chemical biology tools fo... (200730), WT , UKRI | Delineating the roles of ... (MR/N000080/1), UKRI | Switchable gene drives (BB/P009506/1), UKRI | Novel homology-directed g... (MR/N020294/1)

    AbstractMultiple applications of genome editing by CRISPR-Cas9 necessitate stringent regulation and Cas9 variants have accordingly been generated whose activity responds to small ligands, temperature or light. However, these approaches are often impracticable, for examp...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Heather Brant; Helen Atherton; Annemieke Bikker; Tania Porqueddu; Chris Salisbury; Brian McKinstry; John L. Campbell; Andrew Gibson; Sue Ziebland;
    Publisher: Royal College of General Practitioners

    BackgroundThe receptionist is pivotal to the smooth running of general practice in the UK, communicating with patients and booking appointments.AimThe authors aimed to explore the role of the receptionist in the implementation of new approaches to consultations in prima...

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  • publication . Article . 2017
    Open Access
    Authors:
    Tony Robertson; Gayle Beveridge; Catherine Bromley;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: UKRI | Scottish Collaboration fo... (MR/K023209/1)

    Allostatic load is a multiple biomarker measure of physiological ‘wear and tear’ that has shown some promise as marker of overall physiological health, but its power as a risk predictor for mortality and morbidity is less well known. This study has used data from the 20...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Maria Lohan; Aine Aventin; Mike Clarke; Rhonda Curran; Lisa Maguire; Rachael Hunter; Cliona McDowell; Lisa McDaid; Honor Young; James White; ...
    Persistent Identifiers
    Project: UKRI | Social Relationships and ... (MC_UU_12017/11)

    IntroductionTeenage pregnancy remains a worldwide health concern which is an outcome of, and contributor to, health inequalities. The need for gender-aware interventions with a focus on males in addressing teenage pregnancy has been highlighted as a global health need b...

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  • publication . Article . Preprint . 2018
    Open Access
    Authors:
    Joseph P. Anderson; Luc Dessart; Claudia P. Gutiérrez; Thomas Krühler; Lluís Galbany; Anders Jerkstrand; S. J. Smartt; Carlos Contreras; Nidia Morrell; Mark M. Phillips; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NSF | Pan-STARRS1: Operations; ... (1238877), EC | SPCND (615929), UKRI | The transient sky: an int... (ST/I001123/1), EC | ULTRAS (291222), EC | SNSM (702538), UKRI | Queen's University Belfas... (ST/L000709/1), NSF | Measuring the Universe wi... (0306969), NSF | The Carnegie Supernova Pr... (1008343), EC | GAIA-ESO-MW (320360), NSF | The Carnegie Supernova Pr... (0607438)

    Red supergiants have been confirmed as the progenitor stars of the majority of hydrogen-rich type II supernovae. However, while such stars are observed with masses >25M$_\odot$, detections of >18M$_\odot$ progenitors remain elusive. Red supergiants are also expected to ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Naomi R. Wray; Stephan Ripke; Manuel Mattheisen; Maciej Trzaskowski; Abdel Abdellaoui; Mark J. Adams; Esben Agerbo; Tracy Air; Till M.F. Andlauer; Silviu Alin Bacanu; ...
    Project: NIH | DIAGNOSTIC CENTER FOR LIN... (5U01MH046276-03), NIH | UT M.D. Anderson Cancer C... (5P50CA093459-03), NIH | MOLECULAR GENETICS OF SCH... (5R01MH061675-04), NIH | MOLECULAR GENETICS OF SCH... (5R01MH059588-04), NIH | MOLECULAR GENETICS OF SCH... (5R01MH059571-04), NIH | Genome-wide Association S... (5U01MH079470-03), NIH | MOLECULAR GENETICS OF SCH... (1R01MH060870-01), NIH | Genome-Wide Association S... (1R01MH081800-01), NIH | Statistical Methods for G... (5R01CA133996-02), NIH | LINKAGE STUDIES OF SCHIZO... (5U01MH046318-04),...

    Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened\ud risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified\ud 44 independ...

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  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Samuel R. Chamberlain; Jonathan Cavanagh; Peter de Boer; Valeria Mondelli; Declan Jones; Wayne C. Drevets; Philip J. Cowen; Neil A. Harrison; Linda Pointon; Carmine M. Pariante; ...
    Publisher: Royal College of Psychiatrists
    Project: WT | Diagnostically cross-cutt... (110049)

    This work was funded by a Wellcome Trust strategy award to the Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) Consortium which is also funded by Janssen, GlaxoSmithKline, Lundbeck and Pfizer. Recruitment of patients was supported by the National Instit...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Clare Andrews; Loeske E. B. Kruuk; Per T. Smiseth;
    Project: UKRI | Evolution of elaborate pa... (NE/G004293/1)

    Lay Summary Although the evolution of parental care is a central topic in behavioral ecology, we know relatively little about how complex forms of care evolve. We studied elaborate parental care in the burying beetle N. vespilloides. Our results suggest that females dif...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Emma K. Wallace; Elizabeth S. Herrelko; Sonja E. Koski; Sarah-Jane Vick; Hannah M. Buchanan-Smith; Katie E. Slocombe;
    Persistent Identifiers

    The unique challenges faced by animals living in zoos can lead to the production of anxiety-related behaviours. In this study we aimed to understand what specific factors may cause chimpanzees to display these behaviours. In non-human primates, displacement behaviours, ...

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1,091 research outcomes, page 1 of 110