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  • Open Access English
    Authors: 
    Mark Ahearne; Daniel J. Kelly;
    Project: EC | STEMREPAIR (258463)

    The limited intrinsic repair capacity of articular cartilage has led to the investigation of different treatment options to promote its regeneration. The delivery of hydrogels containing stem or progenitor cells and growth factor releasing microspheres represents an attractive approach to cartilage repair. In this study, the influence of the encapsulating hydrogel on the ability of progenitor cells coupled with TGF-β3 releasing microspheres to form cartilaginous tissue was investigated. Fibrin, agarose and gellan gum hydrogels containing TGF-β3 loaded gelatin microspheres and progenitor cells derived from the infrapatellar fat-pad of the knee were cultured for 21 days in a chemically defined media. In the presence of TGF-β3 releasing microspheres, gellan gum hydrogels were observed to facilitate greater cell proliferation than fibrin or agarose hydrogels. Histological and biochemical analysis of the hydrogels indicated that fibrin was the least chondro-inductive of the three hydrogels, while agarose and gellan gum appeared to support more robust cartilage formation as demonstrated by greater sGAG accumulation within these constructs. Gellan gum hydrogels also stained more intensely for collagen type II and collagen type I, suggesting that although total collagen synthesis was higher in these constructs, that the phenotype may be more fibrocartilaginous in nature than normal hyaline cartilage. This study demonstrates how the encapsulating hydrogel can have a significant impact on the ability of stem cells to form cartilage when incorporated into a growth factor delivery system.

  • Open Access
    Authors: 
    Giuseppe Dari-Mattiacci; Eric Langlais; Bruno Lovat; Francesco Parisi;
    Publisher: Elsevier BV

    This paper presents a general rent-seeking model in which participants decide on entry before choosing their levels of efforts. The conventional wisdom in the rent-seeking literature suggests that the rent dissipation increases with the number of potential participants and with their productivity of effort. In this paper, we show that this result of the rent-seeking literature is far from general and applies only when participants are relatively weak and enter the game with certainty. In the presence of strong competitors, the expected total dissipation actually decreases, since participation in the game is less frequent. We further consider the impact of competitors' exit option, distinguishing between "redistributive rent-seeking" and "productive rent-seeking" situations. In redistributive rent-seeking, no social loss results from the fact that all competitors exit the race. In productive rent-seeking, instead, lack of participation creates a social loss (the "lost treasure" effect), since valuable rents are left unexploited. We show that the lost-treasure effect perfectly counterbalances the reduction in rent dissipation due to competitors' exit. Hence, unlike redistributive rent-seeking, in productive rent-seeking the total social loss remains equal to the entire rent even when parties grow stronger or the number of players increases.

  • Open Access Italian
    Authors: 
    LUCCHESE F; SALERNO G; CUTINI, Maurizio; CANEVA, Giulia; CESCHIN, SIMONA;
    Country: Italy
  • Open Access
    Authors: 
    Concetto Puglisi; Filippo Samperi; Sabrina Carroccio; Giorgio Montaudo;
    Country: Italy

    The MALDI-TOF technique allows the detection of intact polymer molecules up to high masses and therefore offers the opportunity to study directly the thermal degradation processes occurring in polymeric materials by analyzing conveniently exposed (i.e., partially degraded) polymer samples. This opens new vistas in polymer analysis and deserves careful exploration, due to the relevance of polymer degradation phenomena in everyday practice.The thermal decomposition of poly(bisphenol A carbonate) (PC) has been investigated by heating isothermally at 300, 350, 400, and 450 °C and subsequent analysis of the pyrolysis residue by means of MALDI mass spectrometry. The MALDI mass spectra of the pyrolysis residues obtained at 300 °C showed a progressive reduction of the abundance of cyclic oligomers, whereas the relative abundance of the other compounds was unaffected. At 350 °C, the occurrence of an extensive hydrolysis reaction was responsible for the degradation of cycles and linear chains bearing tert-butylphenyl carbonate end groups with subsequent formation of abundant open chain PC oligomers with phenol end groups. Furthermore, at these two temperatures, cyclic oligomers never disappear in the MALDI spectra, even at higher heating time (60 min), suggesting the presence of an equilibrium between the rate of cleavage and the rate of formation of cycles. PC chains terminated with phenol groups at both ends, together with pyrolyzed chains bearing phenyl and isopropylidene end groups, generated by the disproportionation of the aliphatic bridge of bisphenol A, were observed in the MALDI spectra of pyrolysis residue obtained at 400 °C. Condensed aromatic compounds such as xanthones, which are considered to be the precursors of a graphite-like structure of the charred residue, were also detected in the MALDI spectra of PC samples heated at 400 °C and they became the most intense species at 450 °C. The PC samples heated at temperature higher than 450 °C consisted of insoluble carbonaceous materials not suitable for MALDI analysis.

  • Publication . Conference object . Preprint . Article . 2010 . Embargo End Date: 01 Jan 2010
    Open Access
    Authors: 
    V. La Parola; L. Ducci; P. Romano; L. Sidoli; G. Cusumano; S. Vercellone; V. Mangano; J. A. Kennea; H. A. Krimm; D. N. Burrows; +4 more
    Publisher: arXiv

    IGR J16479-4514 is a member of the Supergiant Fast X-ray transient (SFXT) class. We present the light curves of its latest outburst, which occurred on January 29, 2009. During this outburst, IGR J16479-4514 showed prolonged activity lasting several days. The presence of eclipses was successfully tested. Comment: Proceeding of X-ray Astronomy 2009 (Bologna, Italy September 7-11, 2009)

  • Publication . Part of book or chapter of book . 2012
    Open Access
    Authors: 
    Trevisan Semi, Emanuela;
    Publisher: Marsilio
    Country: Italy
  • Open Access Italian
    Authors: 
    pecchinenda;
    Country: Italy
  • Publication . Conference object . 2004
    Open Access English
    Authors: 
    ALOISIO, Giovanni; CAFARO, Massimo; S. FIORE; M. MIRTO;
    Publisher: Springer-Verlag and IFMBE, the International Federation for Medical and Biological Engineering
    Country: Italy
  • Open Access English
    Authors: 
    Antonio Turco; Antonio Pennetta; Antonio Caroli; Elisabetta Mazzotta; Anna Grazia Monteduro; Elisabetta Primiceri; Giuseppe E. De Benedetto; Cosimino Malitesta;
    Country: Italy

    Herein we present a straightforward approach for the use of polydopamine (PDA) in adsorption of heavy metals from aqueous solutions. This is achieved by fabricating a healthy and environmentally friendly polydimethylsiloxane (PDMS) foam with a mussel inspired PDA layer deposited on the surface. Critical adsorption parameters (pH, temperature and PDA thickness) are optimized by the application of experimental design methodology. Adsorption kinetics and isotherms are studied in detail evidencing a good fitting with Langmuir isotherm and pseudo-second-order kinetics thus suggesting the occurrence of a chemical sorption process with monolayer nature between metals and PDMS/PDA foam. Intraparticle diffusion model evidences good accessibility and high affinity of binding sites on PDA surface. Once adsorbed, metals are reduced to a lower toxic form and can be then removed by a mild acidic treatment thus being easily collected and stocked.

  • Open Access Italian
    Authors: 
    Zicchittu, P;
    Publisher: Centro di Iniziativa Giuridica Piero Calamandrei
    Country: Italy
Advanced search in
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arrow_drop_down
Searching FieldsTerms
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arrow_drop_down
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Include:
2,321,324 Research products, page 1 of 232,133
  • Open Access English
    Authors: 
    Mark Ahearne; Daniel J. Kelly;
    Project: EC | STEMREPAIR (258463)

    The limited intrinsic repair capacity of articular cartilage has led to the investigation of different treatment options to promote its regeneration. The delivery of hydrogels containing stem or progenitor cells and growth factor releasing microspheres represents an attractive approach to cartilage repair. In this study, the influence of the encapsulating hydrogel on the ability of progenitor cells coupled with TGF-β3 releasing microspheres to form cartilaginous tissue was investigated. Fibrin, agarose and gellan gum hydrogels containing TGF-β3 loaded gelatin microspheres and progenitor cells derived from the infrapatellar fat-pad of the knee were cultured for 21 days in a chemically defined media. In the presence of TGF-β3 releasing microspheres, gellan gum hydrogels were observed to facilitate greater cell proliferation than fibrin or agarose hydrogels. Histological and biochemical analysis of the hydrogels indicated that fibrin was the least chondro-inductive of the three hydrogels, while agarose and gellan gum appeared to support more robust cartilage formation as demonstrated by greater sGAG accumulation within these constructs. Gellan gum hydrogels also stained more intensely for collagen type II and collagen type I, suggesting that although total collagen synthesis was higher in these constructs, that the phenotype may be more fibrocartilaginous in nature than normal hyaline cartilage. This study demonstrates how the encapsulating hydrogel can have a significant impact on the ability of stem cells to form cartilage when incorporated into a growth factor delivery system.

  • Open Access
    Authors: 
    Giuseppe Dari-Mattiacci; Eric Langlais; Bruno Lovat; Francesco Parisi;
    Publisher: Elsevier BV

    This paper presents a general rent-seeking model in which participants decide on entry before choosing their levels of efforts. The conventional wisdom in the rent-seeking literature suggests that the rent dissipation increases with the number of potential participants and with their productivity of effort. In this paper, we show that this result of the rent-seeking literature is far from general and applies only when participants are relatively weak and enter the game with certainty. In the presence of strong competitors, the expected total dissipation actually decreases, since participation in the game is less frequent. We further consider the impact of competitors' exit option, distinguishing between "redistributive rent-seeking" and "productive rent-seeking" situations. In redistributive rent-seeking, no social loss results from the fact that all competitors exit the race. In productive rent-seeking, instead, lack of participation creates a social loss (the "lost treasure" effect), since valuable rents are left unexploited. We show that the lost-treasure effect perfectly counterbalances the reduction in rent dissipation due to competitors' exit. Hence, unlike redistributive rent-seeking, in productive rent-seeking the total social loss remains equal to the entire rent even when parties grow stronger or the number of players increases.

  • Open Access Italian
    Authors: 
    LUCCHESE F; SALERNO G; CUTINI, Maurizio; CANEVA, Giulia; CESCHIN, SIMONA;
    Country: Italy
  • Open Access
    Authors: 
    Concetto Puglisi; Filippo Samperi; Sabrina Carroccio; Giorgio Montaudo;
    Country: Italy

    The MALDI-TOF technique allows the detection of intact polymer molecules up to high masses and therefore offers the opportunity to study directly the thermal degradation processes occurring in polymeric materials by analyzing conveniently exposed (i.e., partially degraded) polymer samples. This opens new vistas in polymer analysis and deserves careful exploration, due to the relevance of polymer degradation phenomena in everyday practice.The thermal decomposition of poly(bisphenol A carbonate) (PC) has been investigated by heating isothermally at 300, 350, 400, and 450 °C and subsequent analysis of the pyrolysis residue by means of MALDI mass spectrometry. The MALDI mass spectra of the pyrolysis residues obtained at 300 °C showed a progressive reduction of the abundance of cyclic oligomers, whereas the relative abundance of the other compounds was unaffected. At 350 °C, the occurrence of an extensive hydrolysis reaction was responsible for the degradation of cycles and linear chains bearing tert-butylphenyl carbonate end groups with subsequent formation of abundant open chain PC oligomers with phenol end groups. Furthermore, at these two temperatures, cyclic oligomers never disappear in the MALDI spectra, even at higher heating time (60 min), suggesting the presence of an equilibrium between the rate of cleavage and the rate of formation of cycles. PC chains terminated with phenol groups at both ends, together with pyrolyzed chains bearing phenyl and isopropylidene end groups, generated by the disproportionation of the aliphatic bridge of bisphenol A, were observed in the MALDI spectra of pyrolysis residue obtained at 400 °C. Condensed aromatic compounds such as xanthones, which are considered to be the precursors of a graphite-like structure of the charred residue, were also detected in the MALDI spectra of PC samples heated at 400 °C and they became the most intense species at 450 °C. The PC samples heated at temperature higher than 450 °C consisted of insoluble carbonaceous materials not suitable for MALDI analysis.

  • Publication . Conference object . Preprint . Article . 2010 . Embargo End Date: 01 Jan 2010
    Open Access
    Authors: 
    V. La Parola; L. Ducci; P. Romano; L. Sidoli; G. Cusumano; S. Vercellone; V. Mangano; J. A. Kennea; H. A. Krimm; D. N. Burrows; +4 more
    Publisher: arXiv

    IGR J16479-4514 is a member of the Supergiant Fast X-ray transient (SFXT) class. We present the light curves of its latest outburst, which occurred on January 29, 2009. During this outburst, IGR J16479-4514 showed prolonged activity lasting several days. The presence of eclipses was successfully tested. Comment: Proceeding of X-ray Astronomy 2009 (Bologna, Italy September 7-11, 2009)

  • Publication . Part of book or chapter of book . 2012
    Open Access
    Authors: 
    Trevisan Semi, Emanuela;
    Publisher: Marsilio
    Country: Italy
  • Open Access Italian
    Authors: 
    pecchinenda;
    Country: Italy
  • Publication . Conference object . 2004
    Open Access English
    Authors: 
    ALOISIO, Giovanni; CAFARO, Massimo; S. FIORE; M. MIRTO;
    Publisher: Springer-Verlag and IFMBE, the International Federation for Medical and Biological Engineering
    Country: Italy
  • Open Access English
    Authors: 
    Antonio Turco; Antonio Pennetta; Antonio Caroli; Elisabetta Mazzotta; Anna Grazia Monteduro; Elisabetta Primiceri; Giuseppe E. De Benedetto; Cosimino Malitesta;
    Country: Italy

    Herein we present a straightforward approach for the use of polydopamine (PDA) in adsorption of heavy metals from aqueous solutions. This is achieved by fabricating a healthy and environmentally friendly polydimethylsiloxane (PDMS) foam with a mussel inspired PDA layer deposited on the surface. Critical adsorption parameters (pH, temperature and PDA thickness) are optimized by the application of experimental design methodology. Adsorption kinetics and isotherms are studied in detail evidencing a good fitting with Langmuir isotherm and pseudo-second-order kinetics thus suggesting the occurrence of a chemical sorption process with monolayer nature between metals and PDMS/PDA foam. Intraparticle diffusion model evidences good accessibility and high affinity of binding sites on PDA surface. Once adsorbed, metals are reduced to a lower toxic form and can be then removed by a mild acidic treatment thus being easily collected and stocked.

  • Open Access Italian
    Authors: 
    Zicchittu, P;
    Publisher: Centro di Iniziativa Giuridica Piero Calamandrei
    Country: Italy
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