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Il 'Venice Squeeze Project', coordinato da Claudia Antonetti, è la prima iniziativa in Italia che intende promuovere il riconoscimento del valore storico e documentario dei calchi epigrafici. Questo progetto ha tra i suoi obiettivi la digitalizzazione e pubblicazione online nel sito web 'E-stampages' della collezione di calchi epigrafici dell’Università Ca’ Foscari. La collezione, che è la più consistente e coerente in Italia, comprende un gruppo più rilevante di calchi prodotti da iscrizioni provenienti dalla Grecia Occidentale, insieme a un nucleo minore di calchi da epigrafi dalla Sicilia e dall’area dell’antica Venetia, per un totale di 605 esemplari. 'E-stampages' è punto di riferimento internazionale per la pubblicazione digitale di cachi epigrafici. Lo standard di digitalizzazione seguito da questo progetto prevede per ogni esemplare una fotografia del recto e del verso e una riproduzione 3D, corredate da metadati che descrivono il calco, il testo e il supporto epigrafico. 'E-stampages' è ad accesso aperto e i dati sono interpolabili e riutilizzabili. Cf. l’articolo citato in ‘Note’. The ‘Venice Squeeze Project’, coordinated by Claudia Antonetti, is the first initiative in Italy to enhance the historical and documentary value of the epigraphic squeezes. Its aims include publishing the Ca’ Foscari collection of epigraphic squeezes within the ’E-stampages’ website. The collection is the richest and most coherent in Italy and it counts 605 items. Most squeezes were produced from inscriptions from Central Greece. A smaller group of squeezes reproduces inscriptions from Sicily and Ancient Venetia. ‘E-stampages’ is an international reference point for digital publishing of epigraphic squeezes. According to the ‘E-stampages digitization standard, each item is reproduced by a photo of the obverse and reverse and a 3D model. The images are supplied with metadata on the squeeze, text and stone. ‘E-stampages is open access and data is interoperable and reusable. Cf. the paper quoted in ‘Notes’.

The Covid-19 pandemic caused by the novel coronavirus SARS-CoV-2 has completely reshaped the lives of people around the world, including higher education students. Beyond serious health consequences for a proportion of those directly affected by the virus, the pandemic holds important implications for the life and work of higher education students, considerably affecting their physical and mental well-being. To capture how students perceived the first wave of the pandemic���s impact, one of the most comprehensive and large-scale online surveys across the world was conducted. Carried out between 5 May 2020 and 15 June 2020, the survey came at a time when most countries were experiencing the arduous lockdown restrictions. The online questionnaire was prepared in seven different languages (English, Italian, North Macedonian, Portuguese, Romanian, Spanish, Turkish) and covered various aspects of higher education students��� life, including socio-demographic and academic characteristics, academic life, infrastructure and skills for studying from home, social life, emotional life and life circumstances. Using the convenience sampling method, the online questionnaire was distributed to higher education students (aged 18 and over) and enrolled in a higher education institution. The final dataset consisted of 31,212 responses from 133 countries and 6 continents. The data may prove useful for researchers studying the pandemic���s impacts on various aspects of student life. Policymakers can utilize the data to determine the best solutions as they formulate policy recommendations and strategies to support students during this and any future pandemic. Acknowledgments: The extensive dataset could not be collected without the numerous international partners who provided the exceptional assistance with questionnaire translation and/or data collection. This work also acknowledges the international partners, who may have been unintentionally omitted from authorship due to the snowball recruitment technique. Special thanks go also to anonymous global survey participants for their valuable insights into the lives of students, which they shared selflessly. The authors also acknowledge the CovidSocLab project (http://www.covidsoclab.org/) as a working platform for international collaboration. Funding: The authors acknowledge the financial support from the Slovenian Research Agency (research core funding No. P5-0093).

Dimorfismo sessuale e diritto divino. Transizione sessuale e diritto matrimoniale canonico. Il transessualismo come causa di inesistenza dell'attogiuridico del matrimonio canonico. La partecipazione del transessuale alla vita della Chiesa

L’elaborato, prendendo avvio dall’evoluzione della partecipazione dei privati ai processi decisionali degli enti locali, opera un approfondimento sul rapporto tra istanze partecipative ed esigenze di efficienza delle politiche pubbliche dall’angolo prospettico del settore dei servizi pubblici locali, recentemente novellato per opera del d.lgs. n. 201/2022. Sebbene la norma in parola annoveri la centralità dell’utenza tra i principi guida della disciplina e affermi il più ampio coinvolgimento nell’istituzione e organizzazione dei servizi, in concreto tale coinvolgimento pare incontrare ancora diverse resistenze.

La produzione e la circolazione di testi, in particolare di carattere agiografico, la traslazione di reliquie, le alleanze matrimoniali ed i trasferimenti temporanei o definitivi di esponenti dell’aristocrazia sono alcune delle chiavi di lettura che possono contribuire a tracciare la storia dei rapporti Nord-Sud nell’altomedioevo. La Toscana da questo punto di vista offre dati interessanti ; ne è un esempio il bavaro Nibelungo, esponente degli Huosi, la cui presenza in Tuscia va inserita in un quadro più ampio che vide l’intensificarsi delle relazioni tra Italia centro-settentrionale e Baviera nella seconda metà dell’VIII secolo. Spesso però la nostra prospettiva è in grado di cogliere solo la superficie degli eventi, mentre è difficile apprezzare la ricaduta dei rapporti internazionali a livello locale. Nel contesto toscano, ed in quello lucchese in particolare, è possibile riscontrarne gli effetti anche all’interno dell’aristocrazia locale, grazie ad una più allargata base partecipativa degli scambi tra Baviera e Toscana tra VIII e IX secolo di quella fino ad ora evidenziata. Questa particolare forma di sincretismo culturale permette meglio di spiegare il radicamento a Lucca della famiglia comitale di Bonifacio, di origine bavara, destinata a reggere le sorti della marca di Tuscia per circa un secolo. meglio di spiegare il radicamento a Lucca della famiglia comitale di Bonifacio, di origine bavara, destinata a reggere le sorti della marca di Tuscia per circa un secolo.

The toxicity and efficacy of intrathecal liposomal cytarabine (LC) were evaluated in children with central nervous system (CNS) relapsed/refractory acute leukemia/lymphoma. Thirty patients (male:female ratio 21:9; median age 9.4 years) with CNS relapsed/resistant disease were treated with intrathecal LC at dosages adjusted for age. Twenty-seven (90%) patients simultaneously received systemic chemotherapy, including concurrent high-dose cytarabine or methotrexate in 21 (70%) cases. Of 28 patients evaluable for response, 25 patients (89%) achieved CNS complete remission and three (11%) partial remission. The median number of intrathecal LC administrations per patient was 4. The cerebrospinal fluid was cleared after a median of 3 intrathecal LC administrations. Neurological toxicity ≥ grade 3 occurred in four (13%) patients. No permanent sequelae were observed. The median overall survival was 20.9 months and the 5-year probability of survival was 46%. These encouraging data suggest that intrathecal LC is well tolerated and effective in children with relapsed/refractory CNS leukemia/lymphoma.

To differentiate gonadotropin deficiency from delayed puberty in teenage boys, 0.1 mg/m2 of triptorelin, a gonadotropin-releasing hormone agonist, was administered subcutaneously at 4 AM. Serum gonadotropins and testosterone levels were determined at baseline and 4 hours after the injection. The increase in blood gonadotropin and testosterone levels was significantly greater in patients with delayed puberty than in those with gonadotropin deficiency.

Among patients with non-small-cell lung cancer (NSCLC), those with pathological stage I have the best expectation of survival; however, survival is reduced to less than 50% in the long term. At present, it is unclear when patients can be reasonably defined as cured, and if they experience a higher incidence of malignant/nonmalignant diseases and a lower expectation of survival than the general population. A total of 134 stage I NSCLC patients, who had undergone resection at the Thoracic Surgery Unit of the General Hospital of Verona (north-eastern Italy) from October 1987 to December 1993, were still disease-free at 5 years. These subjects were further followed up, and morbidity and mortality rates were compared with those recorded in the general population of the same geographical area. The standardised incidence ratios (SIRs) for all malignancies and for lung cancer were higher than expected (2.39, 95% CI=1.6-3.5, P<0.001; 10.1, 95% CI=6.2-15.6, P<0.0001, respectively). The standardised mortality ratio (SMR) was also significantly increased (1.73, 95% CI=1.1-2.6, P=0.013). The excess mortality could be entirely explained by an increase in mortality from lung cancer (5.7, 95% CI=2.8-10.1, P<0.0001). This study shows that patients, resected for pathological stage I NSCLC and tumour-free after 5 years, have a higher incidence of new lung cancer compared with the general population, which in turn determines an excess in all-cause mortality in the following years.