handle: 11562/1125564 , 10278/3727121 , 11384/104844
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The Covid-19 pandemic caused by the novel coronavirus SARS-CoV-2 has completely reshaped the lives of people around the world, including higher education students. Beyond serious health consequences for a proportion of those directly affected by the virus, the pandemic holds important implications for the life and work of higher education students, considerably affecting their physical and mental well-being. To capture how students perceived the first wave of the pandemic���s impact, one of the most comprehensive and large-scale online surveys across the world was conducted. Carried out between 5 May 2020 and 15 June 2020, the survey came at a time when most countries were experiencing the arduous lockdown restrictions. The online questionnaire was prepared in seven different languages (English, Italian, North Macedonian, Portuguese, Romanian, Spanish, Turkish) and covered various aspects of higher education students��� life, including socio-demographic and academic characteristics, academic life, infrastructure and skills for studying from home, social life, emotional life and life circumstances. Using the convenience sampling method, the online questionnaire was distributed to higher education students (aged 18 and over) and enrolled in a higher education institution. The final dataset consisted of 31,212 responses from 133 countries and 6 continents. The data may prove useful for researchers studying the pandemic���s impacts on various aspects of student life. Policymakers can utilize the data to determine the best solutions as they formulate policy recommendations and strategies to support students during this and any future pandemic. Acknowledgments: The extensive dataset could not be collected without the numerous international partners who provided the exceptional assistance with questionnaire translation and/or data collection. This work also acknowledges the international partners, who may have been unintentionally omitted from authorship due to the snowball recruitment technique. Special thanks go also to anonymous global survey participants for their valuable insights into the lives of students, which they shared selflessly. The authors also acknowledge the CovidSocLab project (http://www.covidsoclab.org/) as a working platform for international collaboration. Funding: The authors acknowledge the financial support from the Slovenian Research Agency (research core funding No. P5-0093).
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citations | 1 | |
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influence | Average | |
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handle: 1234/2833111 , 11562/693159 , 11368/2833111
This work presents a method for early detection of epileptic seizures from EEG data, taking into account information about both the temporal and the spatial evolution of the seizures. The system was designed using over 8 hours of EEG, including 10 seizures in 5 patients. Seizure detection was accomplished in three main stages: multiresolution overcomplete decomposition by the à-trous algorithm, feature extraction by computing power spectral density and sample entropy values of subbands and detection by using z-test and support vector machines (SVM). Results highlight large differences between the sub-band sample entropy values during ictal and normal EEG epochs, respectively, reveling a substantial increase of such parameter during the crisis. This enables high detection accuracy and specificity especially in beta and gamma bands (16-125 Hz). The detection performance of the proposed method was evaluated based on the ground truth provided by the expert neurophysiologist, and the results show that our technique is capable to obtain a high accuracy (above the 95% on average), with a high temporal resolution. This enables reaching very low detection latency and early detection of the seizures onset. Furthermore, spatial information, within the limits of the acquisition, on the evolution of the crisis is maintained since all the channels are separately processed.
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bronze |
citations | 0 | |
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handle: 11562/320470
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handle: 11562/241769
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Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications.
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citations | 30 | |
popularity | Top 10% | |
influence | Average | |
impulse | Top 10% |
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handle: 11562/934076 , 11562/734965
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In this issue of Evidence-Based Mental Health , Gartlehner and Gaynes1 comment (see page 98) on our recently published systematic review2 that investigated the comparative efficacy and acceptability of 12 new generation antidepressants (see page 107) . In their view, methodological shortcomings limit the validity of our results and the conclusions reached. In this commentary, our aim is to explain the rationale for doing this systematic review, outline its main findings and address the points raised by Gartlehner and Gaynes.1 Scientific debate can illuminate and clarify complex analyses and we are, therefore, delighted to respond to their critique. While we consider that some of the issues raised are substantive and merit reasoned response, we also believe that some of their criticisms seem rather overstated. We understand that Gartlehner and Gaynes too have published an analysis comparing antidepressants and we note that this is now the third occasion on which they have published similar criticisms of our work.3 ,4 In most countries, demonstration of a difference against placebo, and not against an active comparator, makes a new drug eligible for registration. The European Medicines Agency, for example, is willing to evaluate new antidepressants in the absence of comparison with active existing treatments.5 In situations where no (or a few) active treatments are available, this may not be important. In the field of antidepressants, however, where many potentially effective agents are already available, this process has serious implications. The approval of a new antidepressant as effective and safe in comparison solely with placebo allows the marketing of new drugs that may, in fact, be potentially more effective, similarly effective or even less effective than others currently in use. Many antidepressants have never been directly compared with each other. The picture is further complicated by …
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citations | 5 | |
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handle: 11562/334448
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handle: 11562/1062600
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handle: 11562/1125564 , 10278/3727121 , 11384/104844
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The Covid-19 pandemic caused by the novel coronavirus SARS-CoV-2 has completely reshaped the lives of people around the world, including higher education students. Beyond serious health consequences for a proportion of those directly affected by the virus, the pandemic holds important implications for the life and work of higher education students, considerably affecting their physical and mental well-being. To capture how students perceived the first wave of the pandemic���s impact, one of the most comprehensive and large-scale online surveys across the world was conducted. Carried out between 5 May 2020 and 15 June 2020, the survey came at a time when most countries were experiencing the arduous lockdown restrictions. The online questionnaire was prepared in seven different languages (English, Italian, North Macedonian, Portuguese, Romanian, Spanish, Turkish) and covered various aspects of higher education students��� life, including socio-demographic and academic characteristics, academic life, infrastructure and skills for studying from home, social life, emotional life and life circumstances. Using the convenience sampling method, the online questionnaire was distributed to higher education students (aged 18 and over) and enrolled in a higher education institution. The final dataset consisted of 31,212 responses from 133 countries and 6 continents. The data may prove useful for researchers studying the pandemic���s impacts on various aspects of student life. Policymakers can utilize the data to determine the best solutions as they formulate policy recommendations and strategies to support students during this and any future pandemic. Acknowledgments: The extensive dataset could not be collected without the numerous international partners who provided the exceptional assistance with questionnaire translation and/or data collection. This work also acknowledges the international partners, who may have been unintentionally omitted from authorship due to the snowball recruitment technique. Special thanks go also to anonymous global survey participants for their valuable insights into the lives of students, which they shared selflessly. The authors also acknowledge the CovidSocLab project (http://www.covidsoclab.org/) as a working platform for international collaboration. Funding: The authors acknowledge the financial support from the Slovenian Research Agency (research core funding No. P5-0093).