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47,752 research outcomes, page 1 of 4,776
  • publication . Article . 2021
    Open Access
    Authors:
    Zhongbo Chen; Sonja Scholz; Emil Gustavsson; John Hardy; Kerri Kinghorn;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC

    AbstractKnowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic variation ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Merel Kindt; Marieke Soeter;
    Project: EC | ErasingFear (743263)

    The discovery in animal research that fear memories may change upon retrieval has sparked a wave of interest into whether this phenomenon of reconsolidation also occurs in humans. The critical conditions under which memory reconsolidation can be observed and targeted in...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Asli Ayaz; Andreas Staeuble; Morio Hamada; Marie-Angela Wulf; Aman B Saleem; Fritjof Helmchen;
    Publisher: Nature Publishing Group
    Project: EC | BRAINCOMPATH (670757), SNSF | Two-photon imaging of sta... (PMPDP3_145476), SNSF | Sensorimotor integration ... (PZ00P3_161544), SNSF | Calcium imaging of cellul... (CRSII3_147660), WT | Transforming visual image... (200501)

    Nature Communications, 10 (1)

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  • publication . Article . 2019
    Open Access
    Authors:
    Marion Brickwedde; Marie C. Krüger; Hubert R. Dinse;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC

    Cognition and perception are closely coupled to alpha power, but whether there is a link between alpha power and perceptual learning efficacy is unknown. Here we show that somatosensory alpha power can be successfully up- and down-regulated with short-term neurofeedback...

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  • publication . Article . 2019
    Open Access
    Authors:
    Christopher R. Cooney; Zoë K Varley; Lara O Nouri; Christopher J A Moody; Michael D. Jardine; Gavin H. Thomas;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | TOLERATES (615709)

    Sexual selection is proposed to be a powerful driver of phenotypic evolution in animal systems. At macroevolutionary scales, sexual selection can theoretically drive both the rate and direction of phenotypic evolution, but this hypothesis remains contentious. Here, we f...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Netta Shemesh; Juman Jubran; Shiran Dror; Eyal Simonovsky; Omer Basha; Chanan Argov; Idan Hekselman; Mehtap Abu-Qarn; Ekaterina Vinogradov; Omry Mauer; ...

    The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Through computational analyses of large-scale tissue...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Hanna Susi; Benoit Barrès; Pedro F. Vale; Anna-Liisa Laine;
    Project: EC | PATHEVOL (281517), AKA | Finnish Centre of Excelle... (250444), AKA | Studying pathogen evoluti... (133499), AKA | Within host dynamics driv... (136393)

    Co-infection of plants with multiple pathogen strains is predicted to alter disease dynamics. Here, Susi et al. use experimental and natural population data to show that co-infected host plants spread more disease and cause more devastating epidemics than singly infecte...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Jing Xu; Babu J.N. Reddy; Preetha Anand; Zhanyong Shu; Silvia Cermelli; Michelle K. Mattson; Suvranta K. Tripathy; Matthew T. Hoss; Nikita S. James; Stephen J. King; ...
    Project: NIH | Proteomics of the proteas... (5R01GM074830-05), NIH | Develop new mathematical ... (5P50GM076516-07), NIH | In vivo regulation of bi-... (5R01GM064624-07)

    Kinesin-1 is a plus-end microtubule-based motor, and defects in kinesin-based transport are linked to diseases including neurodegeneration. Kinesin can auto-inhibit via a head-tail interaction, but is believed to be active otherwise. Here we report a tail-independent in...

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  • publication . Preprint . Article . Other literature type . 2021
    Open Access English
    Authors:
    Kengo Watanabe; Kazuhiro Morishita; Xiangyu Zhou; Shigeru Shiizaki; Yasuo Uchiyama; Masato Koike; Isao Naguro; Hidenori Ichijo;
    Publisher: Cold Spring Harbor Laboratory

    Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase se...

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  • publication . Article . 2014
    Open Access
    Authors:
    Alexander M. Dunhill; Bjarte Hannisdal; Michael J. Benton;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC

    The fossil record documents the history of life, but the reliability of that record has often been questioned. Spatiotemporal variability in sedimentary rock volume, sampling and research effort especially frustrates global-scale diversity reconstructions. Various propo...

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47,752 research outcomes, page 1 of 4,776