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85,258 research outcomes, page 1 of 8,526
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Nicoletti, Paola; Aithal, Guruprasad; Bjornsson, Einar; Andrade, Raul; Sawle, Ashley; Arrese, Marco; Barnhart, Huiman; Bondon-Guitton, Emmanuelle; Hayashi, Paul; Bessone, Fernando; ...
    Project: NIH | UT Southwestern: Clinical... (5U01DK083023-02), NIH | CTSA INFRASTRUCTURE FOR A... (5UL1RR024986-05), NIH | Indiana Clinical and Tran... (3UL1RR025761-02S6), NIH | Research Network for Drug... (5U01DK065193-02), NIH | Hepatotoxicity Clinical R... (5U01DK065238-05), NIH | Continuation and Expansio... (5U01DK083027-04), NIH | North Carolina Translatio... (5UL1TR001111-05), NIH | Mount Sinai Regional Drug... (5U01DK100928-03), NIH | Michigan Hepatotoxicity C... (5U01DK065184-07), NIH | Drug-Induced Liver Injury... (5U01DK065201-09),...

    <p>Background &amp; Aims We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. Methods We performed a GWAS of 862 persons with DILI ...

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  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Alison Richards; Alison Richards; Andrew Morden; Andrew Morden; Laurie A. Tomlinson; Jeremy Horwood; Jeremy Horwood; Tracey Stone; Tracey Stone; Fergus Caskey; ...
    Publisher: BMJ Publishing Group
    Project: WT | Drug-associated acute kid... (101143)

    Objectives To summarise evidence on temporary discontinuation of medications to prevent acute kidney injury (AKI). Design Systematic review and meta-analysis of randomised and non-randomised studies. Participants Adults taking diuretics, ACE inhibitors (ACEI), angiotens...

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  • publication . Article . Other literature type . Conference object . 2018
    Open Access English
    Authors:
    Muzlifah Haniffa; Peter Vegh;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: WT | Functional heterogeneity ... (107931), WT

    Abstract Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics techno...

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  • publication . Other literature type . Conference object . Article . 2018
    Open Access
    Authors:
    Anina N. Rich; Joel Pearson; Rocco Chiou; Rocco Chiou; Sebastian Rogers;
    Publisher: Elsevier BV
    Project: WT | Dissecting the dynamics b... (201381), NHMRC | Controlling intrusive ima... (1046198), ARC | Discovery Projects - Gran... (DP140101560), NHMRC | Enhancing the treatment o... (1024800), NHMRC | Fighting mental disorders... (1049596)

    Abstract Individuals with grapheme-colour synaesthesia experience anomalous colours when reading achromatic text. These unusual experiences have been said to resemble ‘normal’ colour perception or colour imagery, but studying the nature of synaesthesia remains difficult...

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  • publication . Article . 2010
    Open Access English
    Authors:
    Karl J. Friston; Dominik R. Bach; Raymond J. Dolan;
    Project: WT

    AbstractAutonomic arousal is often indexed by spontaneous fluctuations in skin conductance. Here, we derive a simple measure of sympathetic arousal, using a convolution model of how sudomotor bursting causes fluctuations in skin conductivity. Under this model, the time-...

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  • publication . Preprint . 2020
    Open Access English
    Authors:
    Nardus Mollentze; Pablo R. Murcia; Roman Biek; Katie Hampson; Daniel G. Streicker;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Respiratory infections (MC_UU_12014/9), WT | Mitigating bat viruses: f... (217221), WT | The Science of Rabies Eli... (207569), WT | Hierarchical epidemiology... (095787), WT | Managing viral emergence ... (102507)

    <jats:title>Abstract</jats:title><jats:p>Whether a pathogen entering a new host species results in a single infection or in onward transmission, and potentially an outbreak, depends upon the progression of infection in the index case. Although index infections are rarel...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Chinelo C. Okigbo; Caroline W. Kabiru; Joyce Mumah; Sanyu A. Mojola; Donatien Beguy;
    Persistent Identifiers
    Publisher: BioMed Central
    Project: WT

    Background Several studies have demonstrated a link between young people’s sexual behavior and levels of parental monitoring, parent-child communication, and parental discipline in Western countries. However, little is known about this association in African settings, e...

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  • publication . Article . 2016
    Open Access
    Authors:
    Katherine Bernadette Burke; Angus John Clarke;
    Persistent Identifiers
    Publisher: BMJ
    Project: WT

    <jats:p>Genome-wide testing methods include array comparative genomic hybridisation (aCGH), multiple gene panels, whole exome sequencing (WE) and whole genome sequencing (WGS). Here we introduce some of the key ethical and social considerations relating to informed cons...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Aung, Nay; Doimo, Sara; Ricci, Fabrizio; Sanghvi, Mihir M.; Pedrosa, Cesar; Woodbridge, Simon P.; Al-Balah, Amer; Zemrak, Filip; Khanji, Mohammed Y.; Munroe, Patricia B.; ...
    Publisher: Lippincott Williams & Wilkins
    Project: WT | The genetic architecture ... (203553)

    Background: Although left ventricular noncompaction (LVNC) has been associated with an increased risk of adverse cardiovascular events, the accurate incidence of cardiovascular morbidity and mortality is unknown. We, therefore, aimed to assess the incidence rate of LVNC...

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  • publication . Article . 2011
    Open Access
    Authors:
    Roslin Russell; Raymond Hui; Y Zhao; Udo Oppermann; Jocelyne Lew; Frank H. Ebetino; Jennifer D. Artz; James E. Dunford; Aiping Dong; Matthieu Schapira; ...
    Persistent Identifiers
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: CIHR , WT

    We present here a study of a eukaryotic trans-prenylsynthase from the malaria pathogen Plasmodium vivax. Based on the results of biochemical assays and contrary to previous indications, this enzyme catalyzes the production of geranylgeranyl pyrophosphate (GGPP) rather t...

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85,258 research outcomes, page 1 of 8,526