<p>Background &amp; Aims We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. Methods We performed a GWAS of 862 persons with DILI ...

Objectives To summarise evidence on temporary discontinuation of medications to prevent acute kidney injury (AKI). Design Systematic review and meta-analysis of randomised and non-randomised studies. Participants Adults taking diuretics, ACE inhibitors (ACEI), angiotens...

Abstract Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics techno...

Abstract Individuals with grapheme-colour synaesthesia experience anomalous colours when reading achromatic text. These unusual experiences have been said to resemble ‘normal’ colour perception or colour imagery, but studying the nature of synaesthesia remains difficult...

AbstractAutonomic arousal is often indexed by spontaneous fluctuations in skin conductance. Here, we derive a simple measure of sympathetic arousal, using a convolution model of how sudomotor bursting causes fluctuations in skin conductivity. Under this model, the time-...

<jats:title>Abstract</jats:title><jats:p>Whether a pathogen entering a new host species results in a single infection or in onward transmission, and potentially an outbreak, depends upon the progression of infection in the index case. Although index infections are rarel...

Background Several studies have demonstrated a link between young people’s sexual behavior and levels of parental monitoring, parent-child communication, and parental discipline in Western countries. However, little is known about this association in African settings, e...

<jats:p>Genome-wide testing methods include array comparative genomic hybridisation (aCGH), multiple gene panels, whole exome sequencing (WE) and whole genome sequencing (WGS). Here we introduce some of the key ethical and social considerations relating to informed cons...

Background: Although left ventricular noncompaction (LVNC) has been associated with an increased risk of adverse cardiovascular events, the accurate incidence of cardiovascular morbidity and mortality is unknown. We, therefore, aimed to assess the incidence rate of LVNC...

We present here a study of a eukaryotic trans-prenylsynthase from the malaria pathogen Plasmodium vivax. Based on the results of biochemical assays and contrary to previous indications, this enzyme catalyzes the production of geranylgeranyl pyrophosphate (GGPP) rather t...