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105,392 research outcomes, page 1 of 10,540
  • publication . Article . 2011
    Open Access English
    Authors:
    Oguike, Mary Chiaka; Betson, Martha; Burke, Martina; Nolder, Debbie; Stothard, J. Russell; Kleinschmidt, Immo; Proietti, Carla; Bousema, Teun; Ndounga, Mathieu; Tanabe, Kazuyuki; ...
    Persistent Identifiers
    Publisher: Elsevier
    Country: United Kingdom
    Project: EC | FIGHTMAL (218164), WT

    It has been proposed that ovale malaria in humans is caused by two closely related but distinct species of malaria parasite, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. It was recently shown that these two parasite types are sympatric at the country level. ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Daniel Stabler; Pier P. Paoli; Susan W. Nicolson; Geraldine A. Wright;
    Persistent Identifiers
    Publisher: The Company of Biologists
    Project: UKRI | Can bees meet their nutri... (BB/I000968/1), WT

    ABSTRACT Animals carefully regulate the amount of protein that they consume. The quantity of individual essential amino acids (EAAs) obtained from dietary protein depends on the protein source, but how the proportion of EAAs in the diet affects nutrient balancing has ra...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Michael Mülleder; Kate Campbell; Olga Matsarskaia; Florian Eckerstorfer; Markus Ralser;
    Publisher: F1000Research
    Project: EC | METABOLICREGULATORS (260809), WT | Metabolic cooperation in ... (200829), WT | Genome-wide analysis of t... (093735)

    Auxotrophic markers are useful tools in cloning and genome editing, enable a large spectrum of genetic techniques, as well as facilitate the study of metabolite exchange interactions in microbial communities. If unused background auxotrophies are left uncomplemented how...

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  • publication . Article . 2016
    Open Access
    Authors:
    Diogo Ribeiro; Marcus D.R. Klarqvist; Ulrica K. Westermark; Ganna Oliynyk; Johanna Dzieran; Anna Kock; Carolina Savatier Banares; Falk Hertwig; John Inge Johnsen; Matthias Fischer; ...
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: WT

    SummaryMYCN amplification and MYC signaling are associated with high-risk neuroblastoma with poor prognosis. Treating these tumors remains challenging, although therapeutic approaches stimulating differentiation have generated considerable interest. We have previously s...

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  • IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated wi...

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Sanna-Cherchi, Simone; Kiryluk, Krzysztof; Burgess, Katelyn E.; Bodria, Monica; Sampson, Matthew G.; Hadley, Dexter; Nees, Shannon N.; Verbitsky, Miguel; Perry, Brittany J.; Sterken, Roel; ...
    Persistent Identifiers
    Publisher: University of Chicago Press
    Countries: Croatia, Italy
    Project: NIH | Genetics of Renal Hypodys... (5R01DK080099-05), EC | HYPERGENES (201550), WT , NIH | Quantitative Genetics of ... (1K23DK090207-01)

    We examined the burden of large, rare, copy-number variants (CNVs) in 192 individuals with renal hypodysplasia (RHD) and replicated findings in 330 RHD cases from two independent cohorts. CNV distribution was significantly skewed toward larger gene-disrupting events in ...

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  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Aryal, Prafulla; Sansom, Mark S.P.; Tucker, Stephen J.;
    Persistent Identifiers
    Country: United Kingdom
    Project: WT

    Abstract Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorabl...

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  • publication . Article . 2010
    Open Access English
    Authors:
    Baxter, Simon W.; Nadeau, Nicola J.; Maroja, Luana S.; Wilkinson, Paul; Counterman, Brian A.; Dawson, Anna; Beltran, Margarita; Perez-Espona, Silvia; Chamberlain, Nicola; Ferguson, Laura; ...
    Publisher: Public Library of Science
    Countries: United States, United Kingdom
    Project: NSF | Collaborative Research: M... (0715096), WT , NSF | The Developmental Archite... (0344705)

    Wing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection. The loci controlling such patterns are “hotspots” for adaptive evolution with great allelic diversity across different ...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Yung, Billy; Hemberger, Myriam; Watson, Erica; Senner, Claire Elizabeth; Jones, Carolyn P; Kaufman, Randal J; Charnock-Jones, Stephen; Burton, Graham;
    Publisher: John Wiley & Sons, Ltd
    Country: United Kingdom
    Project: NIH | Regulation of ER stress-i... (7R01DK088227-03), NIH | Role of the Unfolded Prot... (5R37DK042394-13), NIH | Genetic Core (5P01HL057346-13), NIH | Regulation of Factor FVII... (5R01HL052173-15), WT | The impact of oxidative a... (084804)

    Abstract We recently reported the first evidence of placental endoplasmic reticulum (ER) stress in the pathophysiology of human intrauterine growth restriction. Here, we used a mouse model to investigate potential underlying mechanisms. Eif2s1tm1RjK mice, in which Ser51...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Vanessa L.S. LaPointe; Amanda Verpoorte; Molly M. Stevens;
    Persistent Identifiers
    Publisher: Public Library of Science
    Country: United Kingdom
    Project: WT

    Many cartilage tissue engineering approaches aim to differentiate human mesenchymal stem cells (hMSCs) into chondrocytes and develop cartilage in vitro by targeting cell-matrix interactions. We sought to better inform the design of cartilage tissue engineering scaffolds...

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105,392 research outcomes, page 1 of 10,540