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271,765 research outcomes, page 1 of 27,177
  • publication . Article . Other literature type . 2019
    Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation
    Open Access English
    Authors:
    Joshua R. Smith; Katelyn E. Uithoven; Thomas P. Olson; Jose R. Medina-Inojosa; Erik H. Van Iterson; Ray W. Squires;
    Persistent Identifiers

    doi: 10.3390/jcm8010119

    pmc: PMC6352218

    pmid: 30669449

    Publisher: MDPI AG
    Project: NIH | Peripheral Mechanisms of ... (5R01HL126638-02)

    5 kg/m2) were included. History of diabetes (Odds Ratio (OR): 0.17, 95% Confidence Interval (CI): 0.04&ndash

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  • publication . Article . Other literature type . 2019
    The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells
    Open Access
    Authors:
    Adam C. Goldring; Maryline Beurg; Robert Fettiplace;
    Persistent Identifiers

    doi: 10.1113/jp278799

    pmc: PMC6910908

    pmid: 31633194

    Publisher: Wiley
    Project: NIH | The development of mechan... (5R01DC015439-02)

    Key points Hair cell mechanoelectrical transducer channels are opened by deflections of the hair bundle about a resting position set by incompletely understood adaptation mechanisms.We used three characteristics to define adaptation in hair cell mutants of transmembrane...

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  • publication . Article . Other literature type . 2018
    Mapping the genetic basis of breast microcalcifications and their role in metastasis
    Open Access English
    Authors:
    Chao Zheng; Chao Zheng; Santosh Kumar Paidi; Asif Rizwan; Ishan Barman; Kristine Glunde; Kristine Glunde; Menglin Cheng;
    Persistent Identifiers

    doi: 10.1038/s41598-018-29330-9

    pmc: PMC6056534

    pmid: 30038419

    Publisher: Nature Publishing Group UK
    Project: NIH | Spectroscopy assisted mec... (1DP2GM128198-01), NIH | Hypoxia-derived molecular... (5R01CA213492-02), NIH | MIT Laser Biomedical Rese... (5P41EB015871-28), NIH | Molecular studies of the ... (1R01CA213428-01A1), NIH | Multi-scale Molecular Ima... (5R01CA154725-04)

    Abstract Breast cancer screening and early stage diagnosis is typically performed by X-ray mammography, which detects microcalcifications. Despite being one of the most reliable features of nonpalpable breast cancer, the processes by which these microcalcifications form...

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  • publication . Article . Other literature type . 2016
    Reinventing Biostatistics Education for Basic Scientists
    Open Access English
    Authors:
    Zoran Obradovic; Jerome P. Trzeciakowski; Jelena Milin-Lazovic; Tracey L. Weissgerber; Natasa Milic; Natasa Milic; Vesna D. Garovic; Stacey J. Winham;
    Persistent Identifiers

    doi: 10.1371/journal.pbio.1002430

    pmc: PMC4825954

    pmid: 27058055

    Publisher: Public Library of Science
    Project: NIH | Mayo Clinic Interdiscipli... (5K12HD065987-02)

    How is biostatistics education failing to meet the needs of basic scientists, and what can we do to fix this? This Perspective discusses strategies for making biostatistics an integral part of postgraduate and continuing education for basic scientists, ensuring that cou...

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  • publication . Article . 2001
    Detection of mutations in the dystrophin gene via automated DHPLC screening and direct sequencing
    Open Access English
    Authors:
    Louis M. Kunkel; Louis M. Kunkel; Johan T. den Dunnen; Basil T. Darras; Kristine F O'Brien; Richard R. Bennett;
    Persistent Identifiers

    doi: 10.1186/1471-2156-2-17

    pmc: PMC59832

    pmid: 11710958

    Publisher: BioMed Central
    Project: NIH | CORE--MOLECULAR GENETICS ... (5P30HD018655-21)

    <p>Abstract</p> <p>Background</p> <p>Currently molecular diagnostic laboratories focus only on the identification of large deletion and duplication mutations (spanning one exon or more) for Duchenne Muscular Dystrophy (DMD) yielding 65% of causative mutations. These mut...

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  • publication . Article . 2018
    7B2 chaperone knockout in APP model mice results in reduced plaque burden
    Open Access English
    Authors:
    Polymnia Georgiou; Timothy S. Jarvela; Jason L. Eriksen; Iris Lindberg; Todd D. Gould; Tasha Womack;
    Persistent Identifiers

    doi: 10.1038/s41598-018-28031-7

    pmc: PMC6023903

    pmid: 29955078

    Publisher: Nature Publishing Group UK
    Project: NIH | PLASTICITY AT SYNAPSES IN... (7R01DK045741-08), NIH | Diabetes and its Metaboli... (5T32DK098107-04)

    Abstract Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poor...

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  • publication . Article . 2011
    MoVam7, a conserved SNARE involved in vacuole assembly, is required for growth, endocytosis, ROS accumulation, and pathogenesis of Magnaporthe oryzae.
    Open Access English
    Authors:
    Min Guo; Zhongqiang Qi; Xianying Dou; Qi Wang; Wei Wang; Ping Wang; Zhengguang Zhang; Xiaobo Zheng; Wenwen Song; Haifeng Zhang;
    Persistent Identifiers

    doi: 10.1371/journal.pone.0016439

    pmc: PMC3025985

    pmid: 21283626

    Publisher: Public Library of Science (PLoS)
    Project: NIH | G-protein signaling in Cr... (5R01AI054958-04)

    Soluble NSF attachment protein receptor (SNARE) proteins play a central role in membrane fusion and vesicle transport of eukaryotic organisms including fungi. We previously identified MoSce22 as a homolog of Saccharomyces cerevisiae SNARE protein Sec22 to be involved in...

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  • publication . Article . 2013
    Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse model.
    Open Access English
    Authors:
    Greg Poffenberger; John Virostko; Adrienne N. Dula; Armandla Radhika; Alvin C. Powers; Daniel J. Moore;
    Persistent Identifiers

    doi: 10.1371/journal.pone.0057784

    pmc: PMC3590285

    pmid: 23483929

    Publisher: Public Library of Science (PLoS)
    Project: NIH | Molecular Mechanisms of H... (5U01DK089572-03), NIH | South-Eastern Center for ... (5U24CA126588-02), NIH | Coordinating Center for B... (5U01DK072473-05), NIH | VEGF and Islet Vasculariz... (5R01DK069603-04), NIH | UCHSC DIABETES ENDOCRINOL... (5P30DK057516-04), NIH | Pancreatic Islet Imaging ... (5R01DK068764-02), NIH | GLP-1 to Enhance Islet Tr... (4R33DK066636-03)

    We generated a mouse model (MIP-Luc-VU-NOD) that enables non-invasive bioluminescence imaging (BLI) of beta cell loss during the progression of autoimmune diabetes and determined the relationship between BLI and disease progression. MIP-Luc-VU-NOD mice displayed insulit...

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  • publication . Other literature type . Review . Article . 2010
    The clinical use of structural MRI in Alzheimer disease
    Open Access
    Authors:
    Nick C. Fox; Clifford R. Jack; Philip Scheltens; Paul M. Thompson; Giovanni B. Frisoni;
    Persistent Identifiers

    doi: 10.1038/nrneurol.2009.215

    pmc: PMC2938772

    pmid: 20139996

    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic influences on the... (5R01HD050735-02), NIH | MR HIPPOCAMPAL CHANGES IN... (5R01AG011378-03), RCUK | Defining diseases and tra... (G0801306), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Improving Diagnosis And M... (G0601846), NIH | IN VIVO CORRELATES OF NEU... (3P41RR013642-04S3), NIH | Alzheimers Disease in Mil... (5R01AG020098-05), NIH | GCRC (3M01RR000865-25S1)

    Structural imaging based on magnetic resonance is an integral part of the clinical assessment of patients with suspected Alzheimer dementia. Prospective data on the natural history of change in structural markers from preclinical to overt stages of Alzheimer disease are...

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  • publication . Article . 2019
    Experiencing sexual harassment by males and associated substance use & poor mental health outcomes among adolescent girls in the US
    Open Access
    Authors:
    Jay G. Silverman; Alma I. Behar; Alma I. Behar; Elizabeth Reed; Elizabeth Reed; Niloufar Agah; Marissa Salazar; Marissa Salazar; Eric R. Walsh-Buhi; Anita Raj; ...
    Persistent Identifiers

    doi: 10.1016/j.ssmph.2019.100476

    pmc: PMC6978506

    pmid: 31998825

    Publisher: Elsevier BV
    Project: NIH | Training Program in Subst... (2T32DA023356-06), NIH | STI Risk among adolescent... (1R21HD073610-01A1), NIH | ESTIMA: Empowerment of Se... (5K01MH099969-04)

    Purpose Among a sample of adolescent girls, we assessed: 1) prevalence of sexual harassment by type, place of occurrence, and perpetrators; 2) association with substance use and poor mental health outcomes; and 3) the proportion of girls experiencing sexual harassment i...

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271,765 research outcomes, page 1 of 27,177