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271,765 research outcomes, page 1 of 27,177
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Joshua R. Smith; Katelyn E. Uithoven; Thomas P. Olson; Jose R. Medina-Inojosa; Erik H. Van Iterson; Ray W. Squires;
    Persistent Identifiers
    Publisher: MDPI AG
    Project: NIH | Peripheral Mechanisms of ... (5R01HL126638-02)

    5 kg/m2) were included. History of diabetes (Odds Ratio (OR): 0.17, 95% Confidence Interval (CI): 0.04&ndash

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  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Adam C. Goldring; Maryline Beurg; Robert Fettiplace;
    Persistent Identifiers
    Publisher: Wiley
    Project: NIH | The development of mechan... (5R01DC015439-02)

    Key points Hair cell mechanoelectrical transducer channels are opened by deflections of the hair bundle about a resting position set by incompletely understood adaptation mechanisms.We used three characteristics to define adaptation in hair cell mutants of transmembrane...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Chao Zheng; Chao Zheng; Santosh Kumar Paidi; Asif Rizwan; Ishan Barman; Kristine Glunde; Kristine Glunde; Menglin Cheng;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: NIH | Spectroscopy assisted mec... (1DP2GM128198-01), NIH | Hypoxia-derived molecular... (5R01CA213492-02), NIH | MIT Laser Biomedical Rese... (5P41EB015871-28), NIH | Molecular studies of the ... (1R01CA213428-01A1), NIH | Multi-scale Molecular Ima... (5R01CA154725-04)

    Abstract Breast cancer screening and early stage diagnosis is typically performed by X-ray mammography, which detects microcalcifications. Despite being one of the most reliable features of nonpalpable breast cancer, the processes by which these microcalcifications form...

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  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Zoran Obradovic; Jerome P. Trzeciakowski; Jelena Milin-Lazovic; Tracey L. Weissgerber; Natasa Milic; Natasa Milic; Vesna D. Garovic; Stacey J. Winham;
    Persistent Identifiers
    Publisher: Public Library of Science
    Project: NIH | Mayo Clinic Interdiscipli... (5K12HD065987-02)

    How is biostatistics education failing to meet the needs of basic scientists, and what can we do to fix this? This Perspective discusses strategies for making biostatistics an integral part of postgraduate and continuing education for basic scientists, ensuring that cou...

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  • publication . Article . 2001
    Open Access English
    Authors:
    Louis M. Kunkel; Louis M. Kunkel; Johan T. den Dunnen; Basil T. Darras; Kristine F O'Brien; Richard R. Bennett;
    Persistent Identifiers
    Publisher: BioMed Central
    Project: NIH | CORE--MOLECULAR GENETICS ... (5P30HD018655-21)

    <p>Abstract</p> <p>Background</p> <p>Currently molecular diagnostic laboratories focus only on the identification of large deletion and duplication mutations (spanning one exon or more) for Duchenne Muscular Dystrophy (DMD) yielding 65% of causative mutations. These mut...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Polymnia Georgiou; Timothy S. Jarvela; Jason L. Eriksen; Iris Lindberg; Todd D. Gould; Tasha Womack;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: NIH | PLASTICITY AT SYNAPSES IN... (7R01DK045741-08), NIH | Diabetes and its Metaboli... (5T32DK098107-04)

    Abstract Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poor...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Min Guo; Zhongqiang Qi; Xianying Dou; Qi Wang; Wei Wang; Ping Wang; Zhengguang Zhang; Xiaobo Zheng; Wenwen Song; Haifeng Zhang;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: NIH | G-protein signaling in Cr... (5R01AI054958-04)

    Soluble NSF attachment protein receptor (SNARE) proteins play a central role in membrane fusion and vesicle transport of eukaryotic organisms including fungi. We previously identified MoSce22 as a homolog of Saccharomyces cerevisiae SNARE protein Sec22 to be involved in...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Greg Poffenberger; John Virostko; Adrienne N. Dula; Armandla Radhika; Alvin C. Powers; Daniel J. Moore;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Molecular Mechanisms of H... (5U01DK089572-03), NIH | South-Eastern Center for ... (5U24CA126588-02), NIH | Coordinating Center for B... (5U01DK072473-05), NIH | VEGF and Islet Vasculariz... (5R01DK069603-04), NIH | UCHSC DIABETES ENDOCRINOL... (5P30DK057516-04), NIH | Pancreatic Islet Imaging ... (5R01DK068764-02), NIH | GLP-1 to Enhance Islet Tr... (4R33DK066636-03)

    We generated a mouse model (MIP-Luc-VU-NOD) that enables non-invasive bioluminescence imaging (BLI) of beta cell loss during the progression of autoimmune diabetes and determined the relationship between BLI and disease progression. MIP-Luc-VU-NOD mice displayed insulit...

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  • publication . Other literature type . Review . Article . 2010
    Open Access
    Authors:
    Nick C. Fox; Clifford R. Jack; Philip Scheltens; Paul M. Thompson; Giovanni B. Frisoni;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic influences on the... (5R01HD050735-02), NIH | MR HIPPOCAMPAL CHANGES IN... (5R01AG011378-03), RCUK | Defining diseases and tra... (G0801306), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Improving Diagnosis And M... (G0601846), NIH | IN VIVO CORRELATES OF NEU... (3P41RR013642-04S3), NIH | Alzheimers Disease in Mil... (5R01AG020098-05), NIH | GCRC (3M01RR000865-25S1)

    Structural imaging based on magnetic resonance is an integral part of the clinical assessment of patients with suspected Alzheimer dementia. Prospective data on the natural history of change in structural markers from preclinical to overt stages of Alzheimer disease are...

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  • publication . Article . 2019
    Open Access
    Authors:
    Jay G. Silverman; Alma I. Behar; Alma I. Behar; Elizabeth Reed; Elizabeth Reed; Niloufar Agah; Marissa Salazar; Marissa Salazar; Eric R. Walsh-Buhi; Anita Raj; ...
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: NIH | Training Program in Subst... (2T32DA023356-06), NIH | STI Risk among adolescent... (1R21HD073610-01A1), NIH | ESTIMA: Empowerment of Se... (5K01MH099969-04)

    Purpose Among a sample of adolescent girls, we assessed: 1) prevalence of sexual harassment by type, place of occurrence, and perpetrators; 2) association with substance use and poor mental health outcomes; and 3) the proportion of girls experiencing sexual harassment i...

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271,765 research outcomes, page 1 of 27,177