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44,803 research outcomes, page 1 of 4,481
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Daniel E. Vosberg; Daniel E. Vosberg; Cecilia Flores; Marco Leyton;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: NIH | Amphetamine in adolescenc... (5R01DA037911-04), CIHR

    <jats:title>Abstract</jats:title> <jats:p>Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effec...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Maurice J. Chacron; Brent Doiron; Ashok Litwin-Kumar;
    Persistent Identifiers
    Publisher: Public Library of Science
    Project: CIHR , NSF | Correlations in Neural Dy... (0817141)

    Throughout the central nervous system, the timescale over which pairs of neural spike trains are correlated is shaped by stimulus structure and behavioral context. Such shaping is thought to underlie important changes in the neural code, but the neural circuitry respons...

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  • publication . Article . 2006
    Open Access English
    Authors:
    Vitaly Ostroumov; Ahmed Al-Sabi; Robert J. French; Jeffrey R. McArthur;
    Persistent Identifiers
    Publisher: MDPI AG
    Project: CIHR

    Abstract: Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which underlie generation and propagation of rapid electrical signals in nerve, muscle and heart. Nine different NaV receptor sites, for natural ligands and/or drugs, have been identif...

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  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Diancai Cai; Samuel Schacher; Tyler W. Dunn; Jiang-Yuan Hu; Wayne S. Sossin; Larissa Ferguson; David L. Glanzman; Shanping Chen;
    Persistent Identifiers
    Publisher: bioRxiv
    Project: CIHR , NIH | MECHANISMS MEDIATING LONG... (5R01MH060387-03), NIH | Mechanisms of Long-Term M... (4R01MH096120-05), EC | MECCA (340328)

    <jats:title>Abstract</jats:title><jats:p>Persistent activity of protein kinase M (PKM), the truncated form of protein kinase C (PKC), can maintain long-term changes in synaptic strength in many systems including the hermaphrodite marine mollusk, <jats:italic>Aplysia cal...

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  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Andrea M. Kuczynski; Andrea M. Kuczynski; Jennifer A. Semrau; Jennifer A. Semrau; Adam Kirton; Adam Kirton; Adam Kirton; Sean P. Dukelow; Sean P. Dukelow;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: CIHR

    Abstract Background Detailed kinematics of motor impairment of the contralesional (“affected”) and ipsilesional (“unaffected”) limbs in children with hemiparetic cerebral palsy are not well understood. We aimed to 1) quantify the kinematics of reaching in both arms of h...

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  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Khoja, Leila; Butler, Marcus O.; Kang, S. Peter; Ebbinghaus, Scot; Joshua, Anthony M.;
    Persistent Identifiers
    Publisher: Springer Nature
    Project: CIHR

    The development of the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab and its approval in 2011 for the treatment of metastatic melanoma has heralded a new era in immuno-oncology. Subsequently, novel agents against the programmed death receptor 1 (PD-1)...

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  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Christopher C. Miller; Ilyse Darwish; W. Conrad Liles; Kevin C. Kain;
    Persistent Identifiers
    Publisher: Ivyspring International Publisher
    Project: CIHR

    In vitro, nitric oxide (NO) has been shown to have antimicrobial activity against a wide range of viruses, including influenza A virus. Therefore, we hypothesized that inhaled nitric oxide (iNO) would increase survival in vivo by reducing the viral load in C57Bl/6 mice ...

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  • publication . Article . 2009
    Open Access English
    Authors:
    Michael J. Hendzel; Joan Allalunis-Turner; Jianxun Han; Ivy Ma;
    Persistent Identifiers
    Publisher: Springer Nature
    Project: CIHR

    Introduction Notch is a family of transmembrane protein receptors whose activation requires proteolytic cleavage by γ-secretase. Since aberrant Notch signaling can induce mammary carcinomas in transgenic mice and high expression levels of Notch receptors and ligands cor...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Judy Jung; Christopher Lo; Christopher Lo; Camilla Zimmermann; Camilla Zimmermann; Anne Rydall; Rinat Nissim; Rinat Nissim; Sarah Hales; Sarah Hales; ...
    Persistent Identifiers
    Publisher: BioMed Central
    Project: CIHR

    Background We have developed a novel and brief semi-structured psychotherapeutic intervention for patients with advanced or metastatic cancer, called Managing Cancer And Living Meaningfully. We describe here the methodology of a randomized controlled trial to test the e...

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  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Paromita Deb-Rinker; Chantal Nelson; K.S. Joseph; Laura Arbour; Phil Murphy; Shiliang Liu; Michael S. Kramer; Elizabeth K. Darling; Susie Dzakpasu; Michiel VandenHof; ...
    Persistent Identifiers
    Publisher: Wiley
    Project: CIHR

    Abstract Background There is no international consensus on the definition and components of severe maternal morbidity (SMM). Objectives To propose a comprehensive definition of SMM, to create an empirically justified list of SMM types and subtypes, and to use this to ex...

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44,803 research outcomes, page 1 of 4,481