Background & Aims Up to 25% of patients diagnosed with primary biliary cirrhosis (PBC) are of childbearing age. However, little is known about disease course during pregnancy. Methods We performed a retrospective analysis of women with PBC during pregnancy using a repre...

Being able to argue with a student to convince her or him about the rationale of tutoring hints is an important component of pedagogy In this paper we present an argumentation framework for implementing persuasive tutoring dialogues The entire interaction between the st...

It is now clear dynamic cardiomyoplasty alone will not be able to support patients in severe cardiogenic shock. On the other hand, implantable univentricular electromechanically driven devices for permanent circulatory support are undergoing early clinical trials. Becau...

We analyze the results of a large simulation of an evolving ecosystem to evaluate its complexity. In particular, we are interested to know how close to a stochastic or a deterministic behavior our simulation is. Four methods have been used for this analysis: Higuchi fra...

Abstract Hemispheric brain lateralization can drive the expression of behavioral asymmetry, or laterality, which varies notably both within and among species. To explain these left–right behavioral asymmetries in animals, predator-mediated selection is often invoked. Re...

Abstract We have investigated the question of erythropoietin (Epo) hypersensitivity versus Epo independence as the basis for the endogenous erythroid bursts (EEBs) that develop in cultures without added Epo from hematopoietic cells of polycythemia vera (PV) patients. Us...

The cornea is the transparent barrier between the eye and the environment. Tissue-engineered corneas are currently developed to replace wounded or diseased corneas. Various experimental applications are also foreseen for these tissues reconstructed in vitro by tissue en...

Participants in means-tested programs must periodically document eligibility through a recertification process. If all cases that fail recertification are ineligible, the exact timing of this process should be irrelevant. We find that later recertification interview as...

Background: PSAP encodes saposin C, the co-activator of glucocerebrosidase, encoded by GBA. GBA mutations are associated with idiopathic/isolated REM sleep behavior disorder (iRBD), a prodromal stage of synucleinopathy. Objective: To examine the role of PSAP mutations i...