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67 research outcomes, page 1 of 7
  • publication . Article . 2009
    Open Access
    Authors:
    Giorgos L. Papadopoulos; Panagiotis Alexiou; Manolis Maragkakis; Martin Reczko; Artemis G. Hatzigeorgiou;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Summary: DIANA-mirPath is a web-based computational tool developed to identify molecular pathways potentially altered by the expression of single or multiple microRNAs. The software performs an enrichment analysis of multiple microRNA target genes comparing each set of ...

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  • publication . Other literature type . Article . 2015
    Open Access English
    Authors:
    Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc R. J. Carlson; Benilton S. Carvalho; Héctor Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; ...
    Persistent Identifiers

    Bioconductor is an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology. The project aims to enable interdisciplinary research, collaboration and rapid development of scientific softw...

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  • publication . Article . 2009
    Open Access
    Authors:
    Panagiotis Alexiou; Thanasis Vergoulis; Martin Gleditzsch; George Prekas; Theodore Dalamagas; Molly Megraw; Ivo Grosse; Timos Sellis; Artemis G. Hatzigeorgiou;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3 0 UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims t...

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  • publication . Article . 2016
    Closed Access
    Authors:
    Vasiliki D. Kostiou; Margarita C. Theodoropoulou; Stavros J. Hamodrakas;
    Persistent Identifiers
    Publisher: Elsevier BV

    Heterotrimeric G-proteins form a major protein family, which participates in signal transduction. They are composed of three subunits, Gα, Gβ and Gγ. The Gα subunit is further divided in four distinct families Gs, Gi/o, Gq/11 and G12/13. The goal of this work was to det...

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  • publication . Article . 2017
    Open Access
    Authors:
    John Alexander; Dimitris Mantzaris; Marianthi Georgitsi; Petros Drineas; Peristera Paschou;
    Persistent Identifiers
    Publisher: Springer Nature
    Project: EC | EMTICS (278367), EC | TS-EUROTRAIN (316978)

    Abstract Background The increasing volume and complexity of high-throughput genomic data make analysis and prioritization of variants difficult for researchers with limited bioinformatics skills. Variant Ranker allows researchers to rank identified variants and determin...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Panagiotis Moulos; Pantelis Hatzis;
    Persistent Identifiers
    Publisher: Oxford University Press

    RNA-Seq is gradually becoming the standard tool for transcriptomic expression studies in biological research. Although considerable progress has been recorded in the development of statistical algorithms for the detection of differentially expressed genes using RNA-Seq ...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Kleanthi Lakiotaki; Evgenia Kartsaki; Alexandros Kanterakis; Theodora Katsila; George P. Patrinos; George Potamias;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: WT , EC | RD-CONNECT (305444)

    One of the challenges that arise from the advent of personal genomics services is to efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge. Existing services are limited to either providing static views of PGx variants or applying a s...

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  • publication . Article . 2013
    Open Access
    Authors:
    Maria I. Klapa; Kalliopi Tsafou; Evangelos Theodoridis; Athanasios K. Tsakalidis; Nicholas K. Moschonas;
    Persistent Identifiers
    Publisher: Springer Nature

    Abstract Background Understanding the topology and dynamics of the human protein-protein interaction (PPI) network will significantly contribute to biomedical research, therefore its systematic reconstruction is required. Several meta-databases integrate source PPI dat...

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  • publication . Article . 2006
    Open Access English
    Authors:
    Iain W. Manfield; Chih-Hung Jen; John W. Pinney; Ioannis Michalopoulos; James R. Bradford; Philip M. Gilmartin; David R. Westhead;
    Persistent Identifiers
    Publisher: Oxford University Press

    The Arabidopsis Co-expression Tool, ACT, ranks the genes across a large microarray dataset according to how closely their expression follows the expression of a query gene. A database stores pre-calculated co-expression results for ∼21 800 genes based on data from over ...

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  • publication . Article . 2016
    Open Access
    Authors:
    Aristidis G. Vrahatis; Panos Balomenos; Athanasios K. Tsakalidis; Anastasios Bezerianos;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Summary: DEsubs is a network-based systems biology R package that extracts disease-perturbed subpathways within a pathway network as recorded by RNA-seq experiments. It contains an extensive and customized framework with a broad range of operation modes at all stages of...

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67 research outcomes, page 1 of 7