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  • Publications

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  • Open Access Russian
    Authors: 
    Editorial article;
    Publisher: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»

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  • Open Access
    Authors: 
    S. S. Kurashova; T. K. Dzagurova; A. A. Ishmukhametov; M. S. Egorova; M. V. Balovneva; S. E. Sotskova; E. A. Tkachenko;
    Publisher: SCEEMP

    Addition of adjuvants is a generally recognized method of enhancing the immunogenicity of vaccines. There is a large variety of adjuvants, therefore the choice of an adjuvant is based on the comparison of adjuvants efficacy in animal models, as well as assessment of the...

  • Open Access Russian
    Authors: 
    T. Yu. Kozlova; L. M. Khantimirova; A. V. Rukavishnikov; V. A. Shevtsov;
    Publisher: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»

    This article provides a review on efficacy and safety of tick-borne encephalitis vaccines licensed in the Russian Federation. It highlights that both Russian and imported tick-borne encephalitis vaccines demonstrate high immunogenicity, safety and epidemiological effect...

  • Open Access
    Authors: 
    I. A. Alekseeva; O. V. Perelygina;
    Publisher: SCEEMP

    The study performed as part of evaluation of immunobiological properties of Bordetella pertussis vaccine strains offered an opportunity to standardize pertussis bacterial mass based on the content of surface antigens — agglutinogens 1, 2 and 3. Certain levels of aggluti...

  • Open Access Russian
    Authors: 
    G. A. Trusov; A. A. Chaplenko; I. S. Semenova; E. V. Melnikova; Yu. V. Olefir;
    Publisher: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»

    Flow cytometry is the most common method of identification and quantitation of cell surface markers. Flow cytometry can be used for cell counting and characterization of cell types and subtypes by labeling cells with fluorochrome-conjugated monoclonal antibodies. Manufa...

  • Open Access
    Authors: 
    E. E. Evreinova; L. M. Khantimirova; V. A. Shevtsov; V. A. Merkulov; V. P. Bondarev;
    Publisher: SCEEMP

    Polioviruses belong to Enterovirus C species and cause severe lesions of the nervous system. In the post-polio eradication era, the World Health Organisation recommends inactivated polio vaccines for effective long-term protection of the population. In order to meet the...

  • Open Access

    Current highly sensitive methods for rabies virus and rabies antibodies detection in biological material can be used not only for diagnosis and experimental research, but also for the production of antirabies medicines used for postexposure prophylaxis. The aim of the s...

  • Publication . Article . 2019
    Open Access
    Authors: 
    V. K. Kapitanova; N. E. Petrova; M. Yu. Zhdanova; L. V. Nevskaya;
    Publisher: SCEEMP

    Allergic reactions associated with sensitisation to metals are a common but underexplored problem. Due to the frequent use of metals and their alloys there has been an increase in the number of registered cases of allergic reactions. Recently there have been cases when ...

  • Open Access
    Authors: 
    A. S. Minero; O. B. Runova; O. B. Ustinnikova; A. A. Movsesyants;
    Publisher: SCEEMP

    Quantitative characterisation of excipients in biologicals is an important part of the quality assurance process both at the level of finished products and intermediates, as well as active pharmaceutical ingredients. Ion chromatography with amperometric and conductometr...

  • Open Access
    Authors: 
    M. A. Abdurashitov; N. A. Netesova;
    Publisher: SCEEMP

    Many acute viral infections cause similar clinical symptoms, therefore, establishing the etiology of a viral disease requires the use of whole complexes of serological or PCR tests designed to detect a particular type of pathogen. Modern methods of molecular biology all...