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Advanced well differentiated neuroendocrine tumors (NET) have poor sensitivity to chemotherapy. Biotherapy and targeted therapy are the main treatment options for these patients. Approaches to the 2nd and subsequent lines of treatment have not been developed to date. VE...

The purpose of the study was to investigate the influence of polysaccharides Tussilagofarfara L. on erythroid sprout hematopoiesis, tumor growth and metastasis in mice with Lung cancer-67 during therapy with cisplatin and etoposide. It was found that the use of polysacc...

Melanoma is one of the most dangerous forms of skin cancer. Aggressive growth with a high risk of distant metastasis is the cause of the high death rate from skin melanoma worldwide. Melanoma that has metastasized beyond the lymph nodes requires more aggressive treatmen...

We present the case of a 67-year-old patient diagnosed with retroperitoneal leiomyosarcoma and solitary pulmonary metastasis. The patient underwent left lower lobectomy and retroperitoneal tumor extirpation simultaneously. This surgery resulted in good outcomes and sign...

Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovari...

Formation of intra-abdominal adhesions is a common consequence of abdominal surgery. Operative trauma is an essential component of any surgical intervention. This problem is particularly relevant in patients with intestinal obstruction resulting from a tumor, when it is...

In the literature there has been increased interest in the study of androgenetic receptors (AR) in different molecular subtypes of breast cancer (BC) but we haven’t found consensus about the role of levels of androgens and their metabolites in samples of biological flui...

Uveal melanoma (UM) is the most common primary intra-ocular malignancy. Uveal melanoma is distinct from other subtypes of melanoma by its molecular and genetic characteristics. Somatic mutations in UM tumor involve genes, such as BAP1, EIF1AX, GNA11, GNAQ and SF3B1, tha...

Nowadays, colorectal anastomotic leak is a threatening surgical complication, especially in low and ultralow rectal resections. Attempts to resolve this problem fultimately lead to the creation of permanent stoma. Preservation of rectal anastomosis is an important task,...

Treatment of advanced soft tissue sarcoma (STS) has passed a difficult and long way of evolution from amputation surgery to complex limb-salvage interventions, but the problem of local recurrence is relevant today as 100 years ago. Tactics of monitoring after treatment ...