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356 research outcomes, page 1 of 36
  • publication . Article . 2017
    Open Access Russian
    Authors:
    V. A. Kozlov; D. V. Demina;
    Persistent Identifiers
    Publisher: SPb RAACI

    Increasing amounts of literature data suggest the leading role of indoleamine 2,3-deoxygenase (IDO) enzyme in regulation of immunosuppressive mechanisms. IDO is produced, mostly, by dendritic cells, being induced, e.g., under IFNγ involvement. Its function is to provide...

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  • publication . Article . 2017
    Open Access
    Authors:
    M. M. Zafranskaya; D. B. Nizhegorodova;
    Persistent Identifiers
    Publisher: SPb RAACI

    The ability of mesenchymal stem cells (MSC) to influence the regulatory/suppressive effect in the autoimmune process and promote remyelination allows to consider them a new method of multiple sclerosis (MS) therapy, by means of modifying the disease activity. Genetic st...

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  • publication . Article . 2017
    Open Access Russian
    Persistent Identifiers
    Publisher: SPb RAACI

    Associations between IL1B (rs1143634), IL1RN (VNTR, intron 2), IL4 (VNTR, intron 3), TNFA (rs1800629, rs361525), IL6 (rs1800795), and IL10 (rs1800896) genetic polymorphisms in women with recurrent miscarriage (RM) were analyzed. We studied DNA samples of 112 women with ...

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  • In vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene) in Mph remai...

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  • The article considers the experience of Russian and leading foreign regulatory agencies in organisation and conduction of preclinical and clinical trials of human immunoglobulin products. The authors suggest a classification of human immunoglobulins and provide updated ...

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  • Pre-eclampsia is a multisystemic disease that occurs in the second half of pregnancy, being characterized by the development of hypertension and proteinuria. Pre-eclampsia is still one of the main causes of maternal and neonatal morbidity and mortality. Pre-eclampsia is...

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  • <jats:p>Recent studies have provided strong evidence that long-term ethanol consumption leads to activation the mechanisms of neuroimmune signaling. Recently, much attention has been focused on the study of toll-like receptors (Toll-like receptors, TLRs), which play one...

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  • publication . Article . 2017
    Open Access Russian
    Persistent Identifiers
    Publisher: SPb RAACI

    There are no effective approaches to treatment and prevention of many infectious diseases representing a significant danger to humans. So far, mass vaccine immunization is among the most efficient and widely used approaches to prevent outbreaks of viral and bacterial in...

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  • publication . Article . 2020
    Open Access
    Authors:
    E. V. Kuvschinova; L. M. Kurtasova; A. G. Borisov; A. R. Schmidt; T. A. Gerasimova;
    Persistent Identifiers
    Publisher: SPb RAACI

    Aclinical case ofprimary immunodeficiency state (PIDS) is described: X-linked agammaglobulinemia in the boy of 8 years old. The results of molecular genetic studies: gene btk (ex 1-19) genome version GRCh38.p5, transcript version ENST00000308731 single nucleotide substi...

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  • publication . Article . 2020
    Open Access
    Authors:
    M. S. Bochkova; V. P. Timganova; P. V. Khramtsov; S. V. Uzhviyuk; K. Yu. Shardina; A. I. Nechaev; M. B. Raev; S. A. Zamorina;
    Persistent Identifiers
    Publisher: SPb RAACI

    <jats:p>Graphene and its derivatives are increasingly used in biomedical research. Therefore, the mechanisms and consequences of the interaction of graphene nanoparticles with living objects are intensively studied. The immune system is involved in protecting the body a...

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356 research outcomes, page 1 of 36