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  • Authors: Mastoor M. Abushaega; Yahya H. Daehy; Saleh Alghamdi; Krishna K. Krishnan; +1 Authors

    © 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Jens Birkholzer; Joseph P. Morris; John R. Bargar; F. Brondolo; +24 Authors

    This paper describes a new modeling framework for microscopic to reservoir-scale simulations of hydraulic fracturing and production. The approach builds upon a fusion of two existing high-performance simulators for reservoir-scale behavior: the GEOS code for hydromechanical evolution during stimulation and the TOUGH+ code for multi-phase flow during production. The reservoir-scale simulations are informed by experimental and modeling studies at the laboratory scale to incorporate important micro-scale mechanical processes and chemical reactions occurring within the fractures, the shale matrix, and at the fracture-fluid interfaces. These processes include, among others, changes in stimulated fracture permeability as a result of proppant behavior rearrangement or embedment, or mineral scale precipitation within pores and microfractures, at µm to cm scales. In our new modeling framework, such micro-scale testing and modeling provides upscaled hydromechanical parameters for the reservoir scale models. We are currently testing the new modeling framework using field data and core samples from the Hydraulic Fracturing Field Test (HFTS), a recent field-based joint research experiment with intense monitoring of hydraulic fracturing and shale production in the Wolfcamp Formation in the Permian Basin (USA). Below, we present our approach coupling the reservoir simulators GEOS and TOUGH+ informed by upscaled parameters from micro-scale experiments and modeling. We provide a brief overview of the HFTS and the available field data, and then discuss the ongoing application of our new workflow to the HFTS data set.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio Istituziona...arrow_drop_down
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    Energies
    Other literature type . Article . 2021 . Peer-reviewed
    License: CC BY
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    Energies
    Article . 2021
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    DOAJ
    Article . 2021
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    Energies
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      Energies
      Other literature type . Article . 2021 . Peer-reviewed
      License: CC BY
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      Energies
      Article . 2021
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      DOAJ
      Article . 2021
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      Energies
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Stefano Antonini; Giovanni Montani;

    We analyze the semiclassical polymer dynamics of the inhomogeneous Mixmaster model by choosing the cubed scale factor as the discretized configurational variable, while the anisotropies remain pure Einsteinian variables. Such a modified theory of gravity should be regarded as the appropriate framework to describe the behavior of quantum mean values, both in polymer quantum mechanics and in Loop Quantum Cosmology. We first construct the generalized Kasner solution, including a massless scalar field and a cosmological constant in the dynamics. They account for a quasi-isotropization, inflationary-like mechanism. The resulting scenario links a singularity-free Kasner-like regime with a homogeneous and isotropic de Sitter phase. Subsequently, we investigate the role of the three-dimensional scalar curvature, demonstrating that a bounce of the point-universe against the potential walls can always occur within the polymer framework, also in the presence of a scalar field. However, the absence of the singularity implies that the curvature is bounded. Therefore, the point-universe undergoes an oscillatory regime until it oversteps the potential walls (if the Big Bounce is not reached before). After that, a final stable Kasner-like regime will last all the way toward the Big Bounce. Thus, the present study demonstrates that, as soon as a discretization of the volume of the universe is performed, the generic cosmological solution is non-chaotic and free from singularities. It is likely that the same result can be achieved also in the loop quantum cosmology approach. Comment: 11 pages, 4 figures, to appear on Physics Letters B

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    arXiv.org e-Print Archive
    Other literature type . Preprint . 2018
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    DOAJ
    Article . 2019
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    ENEA Open Archive
    Article . 2019
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    Physics Letters B
    Article . 2019
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    Physics Letters B
    Article . 2019 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    https://doi.org/10.48550/arxiv...
    Article . 2018
    License: arXiv Non-Exclusive Distribution
    Data sources: Datacite
    ENEA Open Archive
    Article . Other ORP type . 2019
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      arXiv.org e-Print Archive
      Other literature type . Preprint . 2018
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      DOAJ
      Article . 2019
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      ENEA Open Archive
      Article . 2019
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      Physics Letters B
      Article . 2019
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      Physics Letters B
      Article . 2019 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      https://doi.org/10.48550/arxiv...
      Article . 2018
      License: arXiv Non-Exclusive Distribution
      Data sources: Datacite
      ENEA Open Archive
      Article . Other ORP type . 2019
      Data sources: ENEA Open Archive
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    Authors: Tweats, David; Eastmond, David A; Lynch, Anthony M; Elhajouji, Azeddine; +6 Authors

    Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between induced aneuploidy occurring after exposure and clonal aneuploidy present in tumours is not clear. Recent evidence indicates that the induction of chromosomal instability (CIN), may be more important than aneuploidy per se, in the carcinogenic process. Down Syndrome, trisomy 21, is associated with altered hematopoiesis in utero which, in combination with subsequent mutations, results in an increased risk for acute megakaryoblastic and lymphoblastic leukemias. In contrast, there is reduced cancer risk for most solid tumours in Down Syndrome. Mouse models with high levels of aneuploidy are also associated with increased cancer risk for particular tumours with long latencies, but paradoxically other types of tumour often show decreased incidence. The aneugens reviewed that induce cancer in humans and animals all possess other carcinogenic properties, such as mutagenicity, clastogenicity, cytotoxicity, organ toxicities, hormonal and epigenetic changes which likely account for, or interact with aneuploidy, to cause carcinogenesis. Although the role that aneuploidy plays in carcinogenesis has not been fully established, in many cases, it may not play a primary causative role. Tubulin-disrupting aneugens that do not possess other properties linked to carcinogenesis, were not carcinogenic in rodents. Similarly, in humans, for the tubulin-disrupting aneugens colchicine and albendazole, there is no reported association with increased cancer risk. There is a need for further mechanistic studies on agents that induce aneuploidy, particularly by mechanisms other than tubulin disruption and to determine the role of aneuploidy in pre-neoplastic events and in early and late stage neoplasia.

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    ENEA Open Archive
    Article . 2019
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    ENEA Open Archive
    Article . 2019
    Data sources: ENEA Open Archive
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      Article . 2019
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      ENEA Open Archive
      Article . 2019
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    Authors: Nicolò G. M. Cultrera; Vania Sarri; Livia Lucentini; Marilena Ceccarelli; +5 Authors

    Gene sequence variation in cultivated olive (Olea europaea L. subsp. europaea var. europaea), the most important oil tree crop of the Mediterranean basin, has been poorly evaluated up to now. A deep sequence analysis of fragments of four genes, OeACP1, OeACP2, OeLUS and OeSUT1, in 90 cultivars, revealed a wide range of polymorphisms along all recognized allele forms and unexpected allele frequencies and genotype combinations. High linkage values among most polymorphisms were recorded within each gene fragment. The great sequence variability corresponded to a low number of alleles and, surprisingly, to a small fraction of genotype combinations. The distribution, frequency, and combination of the different alleles at each locus is possibly due to natural and human pressures, such as selection, ancestrality, or fitness. Phylogenetic analyses of allele sequences showed distant and complex patterns of relationships among cultivated olives, intermixed with other related forms, highlighting an evolutionary connection between olive cultivars and the O. europaea subspecies cuspidata and cerasiformis. This study demonstrates how a detailed and complete sequence analysis of a few gene portions and a thorough genotyping on a representative set of cultivars can clarify important issues related to sequence polymorphisms, reconstructing the phylogeny of alleles, as well as the genotype combinations. The identification of regions representing blocks of recombination could reveal polymorphisms that represent putatively functional markers. Indeed, specific mutations found on the analyzed OeACP1 and OeACP2 fragments seem to be correlated to the fruit weight.

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    CNR ExploRA
    Article . 2019
    Data sources: CNR ExploRA
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    ENEA Open Archive
    Article . 2019
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    DOAJ
    Article . 2019
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    Article . 2019
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      CNR ExploRA
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      ENEA Open Archive
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      DOAJ
      Article . 2019
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      Article . 2019
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    Authors: Joaquín Guillermo Ramírez-Gil; Andrew Townsend Peterson;
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    Journal of Plant Protection Research
    Article . Other ORP type . 2023 . 2019 . Peer-reviewed
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      Journal of Plant Protection Research
      Article . Other ORP type . 2023 . 2019 . Peer-reviewed
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    Authors: Hayes, Mark A; Caselli, Federica;
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    Analytical and Bioanalytical Chemistry
    Article . 2020 . Peer-reviewed
    License: Springer TDM
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      Analytical and Bioanalytical Chemistry
      Article . 2020 . Peer-reviewed
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    Authors: Abdullaziz, Osamah Ibrahiem; Talat, Samer T.; Chiu, Chen-Hao; Wang, Li-Chun;

    In moving train networks, two-hop architecture is adopted to improve users experience by reducing the interaction between on-board users and base stations on the train route. In addition, edge networking have emerged as a solution for bringing services to the proximity of the users. However, deploying two-hop and edge networks do not guarantee a continuous service delivery for train users. When a large number of users transit from the train to the land, they experience service interruption due to control signalling storm and backhaul latency. In this paper, we propose a holistic edge service management system to provide mobile service continuity. The contribution of this paper is twofold. First, we develop an enhanced handover scheme that reduces control signals by handling user mobility at the edge. Second, we develop a pre-copy migration scheme that eliminates backhaul latency by relocating containerized applications to the user proximity across edge train networks. Our experimental results show that the two proposed solution can reduce the control signals and migration downtime by 50% and 36%, respectively. This work has been partially funded by the H2020 col-laborative Europe/Taiwan research project 5G-CORAL (grant no. 761586). This research is also partially supported by the Ministry of Science and Technology, under the Grant Number MOST 108-2634-F-009-006 - through Pervasive Artificial Intelligence Research (PAIR) Labs, Taiwan. This paper has been presented at : IEEE International Symposium on Personal, Indoor and Mobile Radio Communications (IEEE PIMRC 2019). 8-11 September 2019 Istanbul, Turkey In press / En prensa

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1109/pimrc....
    Conference object . 2019 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.1109/pimrc....
      Conference object . 2019 . Peer-reviewed
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    Authors: Nasir Saleem; Muhammad Irfan Khattak; Muhammad Yousaf Ali; Muhammad Shafi;

    Speech enhancement is fundamental for various real time speech applications and it is a challenging task in the case of a single channel because practically only one data channel is available. We have proposed a supervised single channel speech enhancement algorithm in this paper based on a deep neural network (DNN) and less aggressive Wiener filtering as additional DNN layer. During the training stage the network learns and predicts the magnitude spectrums of the clean and noise signals from input noisy speech acoustic features. Relative spectral transform-perceptual linear prediction (RASTA-PLP) is used in the proposed method to extract the acoustic features at the frame level. Autoregressive moving average (ARMA) filter is applied to smooth the temporal curves of extracted features. The trained network predicts the coefficients to construct a ratio mask based on mean square error (MSE) objective cost function. The less aggressive Wiener filter is placed as an additional layer on the top of a DNN to produce an enhanced magnitude spectrum. Finally, the noisy speech phase is used to reconstruct the enhanced speech. The experimental results demonstrate that the proposed DNN framework with less aggressive Wiener filtering outperforms the competing speech enhancement methods in terms of the speech quality and intelligibility.

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    Archives of Acoustics
    Article . Other ORP type . 2023 . 2019 . Peer-reviewed
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      Archives of Acoustics
      Article . Other ORP type . 2023 . 2019 . Peer-reviewed
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    Authors: Masi M.; Freda F.; Clement S.; Cimmino A.; +3 Authors

    5), from the culture filtrates of the fungus Cochliobolus australiensis, a foliar pathogen of buffelgrass (Cenchrus ciliaris), an invasive weed in North America. Among the different metabolites 1 showed target-specific activity against the host plant and no toxicity on zebrafish embryos, promoting its potential use to develop a natural bioherbicide formulation to manage buffelgrass. These data and the peculiar structural feature of 1 suggested to carry out a structure-activity relationship study, preparing some key hemisynthetic derivatives and to test their phytotoxicity. In particular, p-bromobenzoyl, 5-azidopentanoyl, stearoyl, mesyl and acetyl esters of radicinin were semisynthesized as well as the monoacetyl ester of 3-epi-radicinin, the diacetyl esters of radicinol and its 3 epimer, and two hexa-hydro derivatives of radicinin. The spectroscopic characterization and the activity by leaf puncture bioassay against buffelgrass of all the derivatives is reported. Most of the compounds showed phytotoxicity but none of them had comparable or higher activity than radicinin. Thus, the presence of an &alpha unsaturated carbonyl group at C-4, as well as, the presence of a free secondary hydroxyl group at C-3 and the stereochemistry of the same carbon proved to be the essential feature for activity. Radicinin (1), is a fungal dihydropyranopyran-4,5-dione isolated together with some analogues, namely 3-epi-radicinin, radicinol, 3-epi-radicinol, and cochliotoxin (2&ndash ,&beta

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    Molecules
    Other literature type . Article . 2019 . Peer-reviewed
    License: CC BY
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    Molecules
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  • Authors: Mastoor M. Abushaega; Yahya H. Daehy; Saleh Alghamdi; Krishna K. Krishnan; +1 Authors

    © 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

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    Authors: Jens Birkholzer; Joseph P. Morris; John R. Bargar; F. Brondolo; +24 Authors

    This paper describes a new modeling framework for microscopic to reservoir-scale simulations of hydraulic fracturing and production. The approach builds upon a fusion of two existing high-performance simulators for reservoir-scale behavior: the GEOS code for hydromechanical evolution during stimulation and the TOUGH+ code for multi-phase flow during production. The reservoir-scale simulations are informed by experimental and modeling studies at the laboratory scale to incorporate important micro-scale mechanical processes and chemical reactions occurring within the fractures, the shale matrix, and at the fracture-fluid interfaces. These processes include, among others, changes in stimulated fracture permeability as a result of proppant behavior rearrangement or embedment, or mineral scale precipitation within pores and microfractures, at µm to cm scales. In our new modeling framework, such micro-scale testing and modeling provides upscaled hydromechanical parameters for the reservoir scale models. We are currently testing the new modeling framework using field data and core samples from the Hydraulic Fracturing Field Test (HFTS), a recent field-based joint research experiment with intense monitoring of hydraulic fracturing and shale production in the Wolfcamp Formation in the Permian Basin (USA). Below, we present our approach coupling the reservoir simulators GEOS and TOUGH+ informed by upscaled parameters from micro-scale experiments and modeling. We provide a brief overview of the HFTS and the available field data, and then discuss the ongoing application of our new workflow to the HFTS data set.

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    Energies
    Other literature type . Article . 2021 . Peer-reviewed
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