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  • Briefings in Functional Genomics

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  • Open Access English
    Authors: 
    Kafkas, Alex; Montaldi, Daniela;
    Country: United Kingdom
    Project: WT | Is the medial temporal lo... (094597)

    The efficiency of the memory system lies not only in its readiness to detect and retrieve old stimuli but also in its ability to detect and integrate novel information. In this review, we discuss recent evidence suggesting that the neural substrates sensitive to detecti...

  • Open Access
    Authors: 
    Rebecca Preston; Richard W. Naylor; Graham A. Stewart; Agnieszka Bierzynska; Moin A. Saleem; Martin Lowe; Rachel Lennon;
    Publisher: Springer Science and Business Media LLC
    Country: United Kingdom
    Project: WT | Renewal of the Wellcome T... (203128), WT | Targeting force regulatio... (202860), WT

    Abstract Background Lowe syndrome and Dent-2 disease are caused by mutations in the OCRL gene, which encodes for an inositol 5-phosphatase. The renal phenotype associated with OCRL mutations typically comprises a selective proximal tubulopathy, which can manifest as Fan...

  • Open Access English
    Authors: 
    Christopher J. Tape; Stephanie Ling; Maria Dimitriadi; Kelly M. McMahon; Jonathan D. Worboys; Hui Sun Leong; Ida C. Norrie; Crispin J. Miller; George Poulogiannis; Douglas A. Lauffenburger; +1 more
    Countries: United States, United Kingdom
    Project: WT | Quantitative proteomic di... (098847), NIH | Engineered Antibody EGFR ... (5R01CA096504-05), NIH | Regulatory Networks in Ca... (3U54CA112967-05S2)

    Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS[superscript G12D]) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate ph...

  • Open Access English
    Authors: 
    Nestor-Bergmann, Alexander; Johns, Emma; Woolner, Sarah; Jensen, Oliver E.;
    Country: United Kingdom
    Project: WT | Mitotic spindle orientati... (098390)

    We consider a cellular monolayer, described using a vertex-based model, for which cells form a spatially disordered array of convex polygons that tile the plane. Equilibrium cell configurations are assumed to minimize a global energy defined in terms of cell areas and p...

  • Open Access English
    Authors: 
    Laura O'Donovan; Nicola Jane Williams; Stephen Wilkinson;
    Country: United Kingdom
    Project: WT | The Donation and Transfer... (097897), WT

    Abstract Introduction In 2014, Brännström and colleagues reported the first human live birth following uterine transplantation (UTx). Research into this treatment for absolute uterine factor infertility has since grown with clinical trials currently taking place across...

  • Open Access English
    Authors: 
    David Wong; Stephen Gerry; Farah E. Shamout; David A. Clifton; Marco A. F. Pimentel; Peter J. Watkinson;
    Country: United Kingdom
    Project: WT

    ObjectivesNational guidelines for identifying physiological deterioration and sepsis in hospitals depend on thresholds for blood pressure that do not account for age or sex. In populations outside hospital, differences in blood pressure are known to occur with both vari...

  • Open Access English
    Authors: 
    Judit Dénes; Francesca Swords; Eleanor Rattenberry; Karen Stals; Martina Owens; Treena Cranston; Paraskevi Xekouki; Linda B. Moran; Ajith Kumar; Christopher A. Wassif; +41 more
    Publisher: Endocrine Society
    Country: United Kingdom
    Project: WT

    Context: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or in the same family. Coexistence of the two diseases could be due to either a common pathogenic mechanism or a coincidence. Objective: The objective of the invest...

  • Open Access English
    Authors: 
    Dodds, Richard M.; Syddall, Holly E.; Cooper, Rachel; Benzeval, Michaela; Deary, Ian J.; Dennison, Elaine M.; Der, Geoffrey; Gale, Catharine R.; Inskip, Hazel M.; Jagger, Carol; +9 more
    Country: United Kingdom
    Project: UKRI | The Newcastle 85+ Study: ... (G0500997), WT | Lifecourse trajectory of ... (099055), UKRI | Statistics and Econometri... (MC_UU_12013/9), NIH | English Longitudinal Stud... (3R01AG017644-14S2), WT | The Avon Longitudinal Stu... (092731), UKRI | Life course determinants ... (MC_UU_12019/4), UKRI | Integrative epidemiology ... (MC_UU_12013/5)

    Introduction:\ud \ud Epidemiological studies have shown that weaker grip strength in later life is associated with disability, morbidity, and mortality. Grip strength is a key component of the sarcopenia and frailty phenotypes and yet it is unclear how individual measur...

  • Open Access
    Authors: 
    Richard B. Tunnicliffe; Guillaume M. Hautbergue; Stuart A. Wilson; Priti Kalra; Alexander P. Golovanov;
    Publisher: Public Library of Science (PLoS)
    Country: United Kingdom
    Project: UKRI | Studies of multi-componen... (BB/F000588/1), WT

    The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery. ORF57 protein specifically recognizes viral mRNA transcripts, and binds to proteins of the cel...

  • Open Access English
    Authors: 
    Richard Kwizera; Felix Bongomin; Ronald Olum; William Worodria; Freddie Bwanga; David B. Meya; Bruce Kirenga; Robin Gore; David W. Denning; Stephen J. Fowler;
    Publisher: Public Library of Science (PLoS)
    Country: United Kingdom
    Project: WT

    Background Diagnosis of fungal allergies in asthma remains problematic in low-and middle-income countries due to non-availability of point-of-care testing. In this study, we aimed to evaluate the performance of an Aspergillus immunochromatographic technology (ICT) IgG/...