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4 research outcomes, page 1 of 1
  • publication . Article . 2005
    Open Access English
    Authors:
    Yi Ru Gan; He Huang; Yong Dong Huang; Chun Ming Rao; Yang Zhao; Jin Sheng Liu; Lei Wu; Dong-Qing Wei;
    Publisher: Elsevier Inc.

    Abstract The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M pro with the octapeptide AVLQSGFR reported recently...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Qi Shi Du; Shuqing Wang; Yu Zhu; Dong-Qing Wei; Hong Guo; Suzanne Sirois; Kuo-Chen Chou;
    Publisher: Elsevier Inc.

    The cleavage mechanism of severe acute respiratory syndrome (SARS) coronavirus main proteinase (M(pro) or 3CL(pro)) for the octapeptide AVLQSGFR is studied using molecular mechanics (MM) and quantum mechanics (QM). The catalytic dyad His-41 and Cys-145 in the active poc...

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  • publication . Article . 2003
    Open Access
    Authors:
    Guang Wu; Shaomin Yan;
    Publisher: Elsevier BV

    In this study, we analyzed the amino acid pairs affected by mutations in two spike proteins from human coronavirus strains 229E and OC43 by means of random analysis in order to gain some insight into the possible mutations in the spike protein from SARS-CoV. The results...

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  • publication . Article . 2004
    Open Access English
    Authors:
    Guang Wu; Shaomin Yan;
    Publisher: Elsevier Inc.

    This is a further study on the severe acute respiratory syndrome (SARS) using the probabilistic models. The purpose was to define the potential targets for anti-SARS drugs in the structural proteins from human SARS related coronavirus (SARS-CoV) while knowing little abo...

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4 research outcomes, page 1 of 1