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22 research outcomes, page 1 of 3
  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Guoli Shi; Abhilash I. Chiramel; Saliha Majdoul; Kin Kui Lai; Sudipto Das; Paul A. Beare; Thorkell Andresson; Sonja M. Best; Alex A. Compton;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractInfection by SARS-CoV-2 generally causes mild symptoms but can lead to severe disease and death in certain populations, including the immunocompromised. Drug repurposing efforts are underway to identify compounds that interfere with SARS-CoV-2 replication or the...

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  • publication . Article . Preprint . 2021
    Open Access
    Authors:
    Kelly D. Sullivan; Matthew D. Galbraith; Kohl T. Kinning; Kyle Bartsch; Nik Levinsky; Paula Araya; Keith P. Smith; Ross E. Granrath; Jessica R. Shaw; Ryan Baxter; ...
    Publisher: Elsevier BV

    COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients, including matched analysis of the whol...

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  • publication . Preprint . Article . 2021
    Open Access
    Authors:
    Hutchison, James M.; Capone, Ricardo; Luu, Dustin D.; Hadziselimovic, Arina; Van Horn, Wade D.; Sanders, Charles R.;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractSARS-CoV-2 envelope protein (S2-E) is a conserved membrane protein that is essential to coronavirus assembly and budding. Here, we describe the recombinant expression and purification of S2-E into amphipol-class amphipathic polymer solutions. The physical proper...

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  • publication . Preprint . Article . 2020
    Open Access
    Authors:
    Yongjun Tan; Theresa Schneider; Matthew Leong; L. Aravind; Dapeng Zhang;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    ABSTRACTA novel coronavirus (SARS-CoV-2) is the causative agent of an emergent severe respiratory disease (COVID-19) in humans that is threatening to result in a global health crisis. By using genomic, sequence, structural and evolutionary analysis, we show that Alpha- ...

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  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    Emilie Seydoux; Leah J. Homad; Anna J. MacCamy; K. Rachael Parks; Nicholas K. Hurlburt; Madeleine F. Jennewein; Nicholas R. Akins; Andrew B. Stuart; Yu-Hsin Wan; Junli Feng; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days post-infection. Forty-four S2P-specific monoclonal antibodies were generated, three of whic...

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  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Benjamin P. Geisler; Lara Zahabi; Adam E. Lang; Naomi Eastwood; Elaine Tennant; Ljiljan Lukic; Elad Sharon; Hai-Hua Chuang; Chang-Berm Kang; Knakita Clayton-Johnson; ...
    Publisher: BMC

    Abstract Background Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern respiratory syndrome that could inform cl...

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  • publication . Preprint . Article . Other literature type . 2020
    Open Access
    Authors:
    Jared S. Morse; Tyler Lalonde; Shiqing Xu; Wenshe R. Liu;
    Publisher: American Chemical Society (ACS)

    What′s sauce for the goose? Little is known about the coronavirus causing the current outbreak; however, it shares strong sequence homology with its better‐studied cousin SARS‐CoV. Based on previous studies of targeting SARS‐CoV, we suggest four potential candidates tha...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Bo Wang; Oliver Van Oekelen; Tarek H. Mouhieddine; Diane Marie Del Valle; Joshua Richter; Hearn Jay Cho; Shambavi Richard; Ajai Chari; Sacha Gnjatic; Miriam Merad; ...
    Publisher: Cold Spring Harbor Laboratory

    Abstract Background The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients during the pandemic in New York City. The pandemic directly impacted cancer patients and the or...

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  • <p>We prepared the three-dimensional model of the 2019-nCoV 3C-like protease (3CL<sup>pro</sup>) using the crystal structure of the highly-similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding and ...

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  • publication . Preprint . Other literature type . Article . 2020
    Open Access English
    Authors:
    Sara Cleemput; Wim Dumon; Vagner Fonseca; Wasim Abdool Karim; Marta Giovanetti; Luiz Carlos Junior Alcantara; Koen Deforche; Tulio de Oliveira;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | VIROGENESIS (634650), NIH | H3ABioNet: informatics so... (5U24HG006941-07)

    Em decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto. Submitted by Raphael Belchior (raphael.rodrigues@icict.fiocruz.br) on 2020-03-17T00:53:39Z No. of bitstreams: 3 btaa145.pdf: 362976 bytes, checksum: 0d2469a8ebdc8f9bc014de13bd6...

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22 research outcomes, page 1 of 3