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3 research outcomes, page 1 of 1
  • other research product . 2011
    Open Access English
    Authors:
    Pols, Thijs W.H.; Noriega, Lilia G.; Nomura, Mitsunori; Auwerx, Johan; Schoonjans, Kristina;
    Publisher: S. Karger AG
    Project: EC | SIRTUINS (231138)

    Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling molecules that...

  • other research product . 2011
    Open Access English
    Authors:
    Bai Péter; Oudart Hugues; Gergely Pál; Menissier-de Murcia Josiane; Schreiber Valérie; Sauve Anthony A; Auwerx Johan; Canto Carles; Brunyánszki Attila; Huber Aline; ...
    Project: EC | SIRTUINS (231138)

    SIRT1 is a NAD(+) dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here we tested whether deletion of PARP 2 an alternative NAD(+) consuming enzyme impacts on NAD(+) bioavailability and SIRT1 activity. Our r...

  • other research product . undefined
    Open Access English
    Publisher: Nature Publishing Group
    Project: EC | SIRTUINS (231138)

    Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitr...

3 research outcomes, page 1 of 1