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845 research outcomes, page 5 of 85
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Lijuan Zhang;
    Publisher: Public Library of Science
    Project: CIHR , NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | "MR Morphometrics and Cog... (5K01AG030514-02)

    Detecting early morphological changes in the brain and making early diagnosis are important for Alzheimer's disease (AD). High resolution magnetic resonance imaging can be used to help diagnosis and prediction of the disease. In this paper, we proposed a machine learnin...

  • publication . Article . 2018
    Open Access English
    Authors:
    Lee, Younghee; Han, Seonggyun; Kim, Dongwook; Kim, Dokyoon; Horgousluoglu, Emrin; Risacher, Shannon L.; Saykin, Andrew J; Nho, Kwangsik;
    Publisher: American Medical Informatics Association
    Project: NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Neurogenesis in Adult Bra... (5R03AG054936-02), NIH | Bioinformatics Strategies... (5R01LM011360-03), NIH | Integrating Neuroimaging,... (1R01LM012535-01), NSF | III: Small: Collaborative... (1117335), NIH | Clinical Core - Pharmacog... (1P50GM115318-01), NIH | Sensory and Perceptual Me... (5K01AG049050-02), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08), NIH | National Cell Repository ... (5U24AG021886-09),...

    Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products. We developed a splicing decision model to identify actionable loci among common SNPs for gene regu...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Farzaneh Elahifasaee; Fan Li; Ming Yang;
    Publisher: Hindawi
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    <jats:p>Magnetic resonance (MR) imaging is a widely used imaging modality for detection of brain anatomical variations caused by brain diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). AD considered as an irreversible neurodegenerative disor...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Vermunt, Lisa; van Paasen, Alegría J.L.; Teunissen, Charlotte E.; Scheltens, Philip; Visser, Pieter Jelle; Tijms, Betty M.; for the Alzheimer's Disease Neuroimaging Initiative;
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , EC | EPAD (115736)

    OBJECTIVE: To identify potential predictors for outcome in individuals with mild cognitive impairment (MCI) who have reverted to normal cognition (NC). METHODS: We selected individuals with MCI, who reverted at follow-up to NC, with follow-up after reversion from Alzhei...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Lorenzi, Marco; Ayache, Nicholas; Pennec, Xavier;
    Publisher: HAL CCSD
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | CORE-- CLINICAL (3P30AG010129-11S1), CIHR , NIH | "MR Morphometrics and Cog... (5K01AG030514-02)

    International audience; In this study we introduce the regional flux analysis, a novel approach to deformation based morphometry based on the Helmholtz decomposition of deformations parameterized by stationary velocity fields. We use the scalar pressure map associated t...

  • publication . Article . 2019
    Open Access English
    Authors:
    Zhanxiong Wu; Zhanxiong Wu; Dong Xu; Dong Xu; Thomas Potter; Yingchun Zhang; The Alzheimer's Disease Neuroimaging Initiative;
    Publisher: Frontiers Media S.A.
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Alzheimer's disease (AD) causes the progressive deterioration of neural connections, disrupting structural connectivity (SC) networks within the brain. Graph-based analyses of SC networks have shown that topological properties can reveal the course of AD propagation. Di...

  • publication . Article . 2015
    Open Access English
    Authors:
    Grill, Joshua D; Raman, Rema; Ernstrom, Karin; Aisen, Paul; Dowsett, Sherie A; Chen, Yun-Fei; Liu-Seifert, Hong; Hake, Ann Marie; Miller, David S; Doody, Rachelle S; ...
    Publisher: BioMed Central
    Project: NIH | ALZHEIMERS DISEASE COOPER... (5U01AG010483-07), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | A Phase 2 Trial of AAV-NG... (1R01AG030048-01A1), NIH | UCLA Alzheimers Disease R... (3P50AG016570-07S1), NIH | VITAMIN E TRIAL IN PERSON... (5R01AG016381-07)

    © 2015 Grill et al.; licensee BioMed Central. Introduction: Most Alzheimer's disease (AD) clinical trials enroll participants multinationally. Yet, few data exist to guide investigators and sponsors regarding the types of patients enrolled in these studies and whether p...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Whitwell, J. L.; Weigand, S. D.; Boeve, B. F.; Senjem, M. L.; Gunter, J. L.; DeJesus-Hernandez, M.; Rutherford, N. J.; Baker, M.; Knopman, D. S.; Wszolek, Z. K.; ...
    Publisher: Oxford University Press (OUP)
    Project: NIH | Progranulin, TAR DNA bind... (2R56AG026251-03A1), NIH | An Investigation Into Aty... (5R21AG038736-02), NIH | PD iPS Cell Line Research... (1RC2NS070276-01), NIH | ALZHEIMERS DISEASE PATIEN... (2U01AG006786-04), NIH | Mayo Alzheimers Disease R... (3P50AG016574-06S1), NIH | Tau and Neurodegeneration... (3P01AG017216-07S1), NIH | Genetic Consortium for La... (5U24AG026395-04), NIH | PIB PET Scanning in Speec... (5R01DC010367-02), NIH | The ARIC and Neurocogniti... (5R01HL070825-03), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01),...

    A major recent discovery was the identification of an expansion of a non-coding GGGGCC hexanucleotide repeat in the C9ORF72 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis. Mutations in two other genes are known to account for familial fr...

  • publication . Article . 2014
    Open Access English
    Authors:
    Pérez-Palma E; Bi, Bustos; Cf, Villamán; Ma, Alarcón; Me, Avila; Gd, Ugarte; Ae, Reyes; Opazo C; Giancarlo De Ferrari; Disease Neuroimaging Initiative, Alzheimer S.; ...
    Publisher: PUBLIC LIBRAY OF SCIENCE
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Genome-wide association studies (GWAS) have successfully identified several risk loci for Alzheimer's disease (AD). Nonetheless, these loci do not explain the entire susceptibility of the disease, suggesting that other genetic contributions remain to be identified. Here...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Shannon L Risacher; Sungeun eKim; Sungeun eKim; Li eShen; Li eShen; Kwangsik eNho; Tatiana eForoud; Robert C Green; Ronald C Petersen; Clifford R Jack; ...
    Publisher: Frontiers Media S.A.
    Project: NIH | Indiana Clinical and Tran... (1TL1RR025759-01), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | ALZHEIMERS DISEASE COOPER... (5U01AG010483-07), NIH | Amyloid Imaging in Fronto... (1R01AG027859-01A1), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NIH | A Phase 2 Trial of AAV-NG... (1R01AG030048-01A1), NIH | CORE-- CLINICAL (3P30AG010129-11S1), CIHR , NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08),...

    Objective: Our goal was to evaluate the association of APOE with amyloid deposition, cerebrospinal fluid levels (CSF) of Aβ, tau, and p-tau, brain atrophy, cognition and cognitive complaints in E-MCI patients and cognitively healthy older adults (HC) in the ADNI-2 cohor...

845 research outcomes, page 5 of 85
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