Quick search
Advanced search in
Field to searchTerm
Add rule
Filters (2 )
Download Results
449 research outcomes, page 4 of 45
  • publication . Article . 2014
    Open Access English
    Authors:
    Xin Qiu; Xiaowei Shen; Osvaldo Espin-Garcia; Abul Azad; Geoffrey Liu; Wei Xu;
    Publisher: BioMed Central
    Project: NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    In a genome-wide association study, association between disease trait and hundreds of thousands of genetic markers are tested. Several methods have been proposed to control the false discovery rate in such high-throughput data to adjust for multiple hypotheses testing. ...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Wang, Yuanjia; Sha, Nanshi; Fang, Yixin;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Functional Data Analysis ... (5R03AG031113-02)

    <p>Abstract</p> <p>Single-locus analysis is often used to analyze genome-wide association (GWA) data, but such analysis is subject to severe multiple comparisons adjustment. Multivariate logistic regression is proposed to fit a multi-locus model for case-control data. H...

  • publication . Article . 2014
    Open Access English
    Authors:
    Nalpathamkalam, Thomas; Derkach, Andriy; Paterson, Andrew D; Merico, Daniele;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | Discovery of Functional V... (5U01DK085524-05)

    Grouping variants based on gene mapping can augment the power of rare variant association tests. Weighting or sorting variants based on their expected functional impact can provide additional benefit. We defined groups of prioritized variants based on systematic annotat...

  • publication . Article . 2018
    Open Access English
    Authors:
    Wang Wei; Wei Zhi;
    Publisher: BioMed Central
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | Multiethnic Study of Type... (5U01DK085526-05)

    Advances in next-generation sequencing technology have made it possible to comprehensively interrogate the entire spectrum of genomic variations including rare variants. They may help capture the remaining genetic heritability which has not been fully explained by previ...

  • publication . Article . 2009
    Open Access English
    Authors:
    Wang, Xuexia; Qin, Huaizhen; Sha, Qiuying;
    Publisher: Springer Nature
    Project: NIH | Statistical Methods for M... (1R01GM069940-01A2), NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    In genome-wide association studies, new schemes are needed to incorporate multiple-locus information. In this article, we proposed a two-stage sliding-window approach to detect associations between a disease and multiple genetic polymorphisms. In the proposed approach, ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Summaira Yasmeen; Patricia Burger; Stefanie Friedrichs; Sergi Papiol; Heike Bickeböller;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Abstract In GAW20, we investigated the association of specific genetic regions of interest (ROIs) with log-transformed triglyceride (TG) levels following lipid-lowering medication using epigenetic and genetic markers. The goal was to incorporate kernels for cytosine-pho...

  • publication . Article . 2009
    Open Access English
    Authors:
    Hae-Won Uh; Henk Jan van der Wijk; Jeanine J Houwing-Duistermaat;
    Publisher: BMC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>We investigated efficient case-control association analysis using family data. The outcome of interest was coronary heart disease. We employed existing and new methods that take into account the correlations among related individuals to obtain the pro...

  • publication . Article . 2011
    Open Access
    Authors:
    Niu Yue S; Hao Ning; An Lingling;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>Genome-wide association studies have been firmly established in investigations of the associations between common genetic variants and complex traits or diseases. However, a large portion of complex traits and diseases cannot be explained well by comm...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Qiu, Yumou; Xu, Zheng; Cui, Juan; Duan, Qing; Wu, Cong; Jia, Qidong; Clarke, Jennifer;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Abstract Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different g...

  • publication . Article . 2018
    Open Access
    Authors:
    Xuexia Wang; Felix Boekstegers; Regina Brinster;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Abstract Background This paper summarizes the contributions from the Genome-wide Association Study group (GWAS group) of the GAW20. The GWAS group contributions focused on topics such as association tests, phenotype imputation, and application of empirical kinships. The...

449 research outcomes, page 4 of 45
Last index information