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57,273 research outcomes, page 4 of 5,728
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Olivier Brönnimann;
    Publisher: Wiley
    Project: EC | CONSTRAINTS (639706), RCUK | The role of trade-offs in... (NE/M018458/1), SNSF | Roles of Class IA PI3K is... (PBLAP3_140100), EC | GEODEM (658651), SFI | POPSTAR-SFI: Plant popula... (15/ERCD/2803), ARC | Discovery Early Career Re... (DE140100505)

    Abstract Correlative species distribution models are based on the observed relationship between species’ occurrence and macroclimate or other environmental variables. In climates predicted less favourable populations are expected to decline, and in favourable climates t...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    M. Sivade; M. Koch; A. Shrivastava; D. Alonso-López; J. De Las Rivas; N. del-Toro; C. W. Combe; B. H. M. Meldal; J. Heimbach; J. Rappsilber; ...
    Publisher: BMC
    Project: WT | Core Funding for the Well... (203149), RCUK | MIDAS - Molecular Interac... (BB/L024179/1), WT | Protein structures in the... (103139)

    [Background]: A number of different molecular interactions data download formats now exist, designed to allow access to these valuable data by diverse user groups. These formats include the PSI-XML and MITAB standard interchange formats developed by Molecular Interactio...

  • publication . Article . 2012
    Open Access
    Authors:
    Jakub Nedbal; Philip S Hobson; David J Fear; Rainer Heintzmann; Hannah J Gould;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Exploring, Understanding ... (G0501494), RCUK | Light Efficient Detection... (EP/F069731/1), RCUK | Mechanism and manipulatio... (BB/H019634/1)

    We present a web engine boosted fluorescence in-situ hybridization (webFISH) algorithm using a genome-wide sequence similarity search to design target-specific single-copy and repetitive DNA FISH probes. The webFISH algorithm featuring a user-friendly interface (http://...

  • publication . Article . 2015
    Open Access English
    Authors:
    Hyde, PJ; Fisher, J; Hall, RM;
    Publisher: John Wiley and Sons Inc.
    Project: WT | Engineering Solutions for... (088908), RCUK | DTA - University of Leeds (EP/P504988/1), NIH | Wear Analysis of Interver... (5R01AR052653-03)

    The effect of kinematics, loading and centre of rotation on the wear of an unconstrained total disc replacement have been investigated using the ISO 18192-1 standard test as a baseline. Mean volumetric wear rate and surface morphological effects were reported. Changing ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Hughes, Katherine; Watson, Christine;
    Publisher: MDPI AG
    Project: RCUK | Lysosomes in the mammary ... (MR/J001023/1), RCUK | The inflammatory microenv... (MR/N022963/1)

    Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most usually activated by phosphorylation of a specific tyrosine residue, a staggering wealth of research has delineat...

  • publication . Article . 2019
    Open Access English
    Authors:
    Matthews, Nicholas E.; Stamford, Laurence; Shapira, Philip;
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), RCUK | DTA - The University of M... (EP/M506436/1), RCUK | DTP - The University of M... (EP/M507969/1), RCUK | DTP 2016-2017 The Univers... (EP/N509565/1)

    Graphical abstract

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Rogers Mark F; Shihab Hashem A; Mort Matthew; Cooper David N; Gaunt Tom R; Campbell Colin;
    Publisher: Oxford University Press
    Project: RCUK | Novel Methodology for pre... (EP/M01715X/1), RCUK | An Active Learning Approa... (EP/K008250/1)

    Abstract Summary We present FATHMM-XF, a method for predicting pathogenic point mutations in the human genome. Drawing on an extensive feature set, FATHMM-XF outperforms competitors on benchmark tests, particularly in non-coding regions where the majority of pathogenic ...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Ganyani, Tapiwa; Roosa, Kimberlyn; Faes, Christel; Hens, Niel; Chowell, Gerardo;
    Publisher: Cambridge University Press (CUP)
    Project: RCUK | US-UK EEID Collab: Risks ... (BB/M008894/1), NSF | US-UK Collab: Risks of An... (1414374)

    <jats:title>Abstract</jats:title><jats:p>We assess the relationship between epidemic size and the scaling of epidemic growth of Ebola epidemics at the level of administrative areas during the 2014–16 Ebola epidemic in West Africa. For this purpose, we quantify growth sc...

  • publication . Article . 2012
    Open Access English
    Authors:
    Oczypok, Elizabeth A.; Etheridge, Timothy; Freeman, Jacob; Stodieck, Louis; Johnsen, Robert; Baillie, David; Szewczyk, Nathaniel J.;
    Publisher: Royal Society, The
    Project: NIH | Gene Networks Regulating ... (7R01AR054342-02), RCUK | A genetic model for under... (G0801271)

    The ultimate survival of humanity is dependent upon colonization of other planetary bodies. Key challenges to such habitation are (patho)physiologic changes induced by known, and unknown, factors associated with long-duration and distance space exploration. However, we ...

  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    Siddhant Gangapurwala; Alexander Mitchell; Ioannis Havoutis;
    Project: RCUK | Robust Legged Locomotion ... (EP/S002383/1)

    Deep reinforcement learning (RL) uses model-free techniques to optimize task-specific control policies. Despite having emerged as a promising approach for complex problems, RL is still hard to use reliably for real-world applications. Apart from challenges such as preci...

57,273 research outcomes, page 4 of 5,728
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