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449 research outcomes, page 3 of 45
  • publication . Article . 2016
    Open Access
    Authors:
    Pitsillides, Achilleas N.; Choi, Seung-Hoan; Hogan, John D.; Hong, Jaeyoung; Lin, Honghuang;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Background Expression quantitative trait locus (eQTL) maps are considered a valuable resource in studying complex diseases. The availability of gene expression data from the Genetic Analysis Workshop 19 (GAW19) provides a great opportunity to investigate the association...

  • publication . Article . 2009
    Open Access English
    Authors:
    Parkhomenko Elena; Tritchler David; Lemire Mathieu; Hu Pingzhao; Beyene Joseph;
    Publisher: BioMed Central
    Project: NSERC , NIH | Genetic Analysis of Commo... (5R01GM031575-22), CIHR

    <p>Abstract</p> <p>In high-dimensional studies such as genome-wide association studies, the correction for multiple testing in order to control total type I error results in decreased power to detect modest effects. We present a new analytical approach based on the high...

  • publication . Article . 2014
    Open Access
    Authors:
    Zhang, Tian-Xiao; Xie, Yi-Ran; Rice, John P;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | NIMH Center for Collabora... (3U24MH068457-07S2), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | Multiethnic Study of Type... (5U01DK085526-05)

    Rare variants have been proposed to play a significant role in the onset and development of common diseases. However, traditional analysis methods have difficulties in detecting association signals for rare causal variants because of a lack of statistical power. We prop...

  • publication . Article . 2007
    Open Access English
    Authors:
    Yang, Yang; Tashman, Adam P; Lee, Jung Yeon; Yoon, Seungtai; Mao, Wenyang; Ahn, Kwangmi; Kim, Wonkuk; Mendell, Nancy R; Gordon, Derek; Finch, Stephen J;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | PLEIOTROPIC EFFECTS OF GE... (3R01MH071523-01A2S1)

    <p>Abstract</p> <p>About 28% of genes appear to have an expression pattern that follows a mixture distribution. We use first- and second-order partial correlation coefficients to identify trios and quartets of non-sex-linked genes that are highly associated and that are...

  • publication . Article . 2014
    Open Access English
    Authors:
    Ally Rogers; Andrew Beck; Nathan L Tintle;
    Publisher: Springer Nature
    Project: NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Evaluating the Cost Effec... (3R15HG004543-01S2), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Analyzing the behavior an... (2R15HG006915-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    Genotype errors are well known to increase type I errors and/or decrease power in related tests of genotype-phenotype association, depending on whether the genotype error mechanism is associated with the phenotype. These relationships hold for both single and multimarke...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Haakon E Nustad; Christian M Page; Andrew H Reiner; Manuela Zucknick; Marissa LeBlanc;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Abstract Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate genome-wide patterns of DNA methylation heritability...

  • publication . Article . 2017
    Open Access English
    Authors:
    Carla Chia-Ming Chen; Jonathan Macgregor Keith; Kerrie Lee Mengersen;
    Publisher: Public Library of Science
    Project: NHMRC | Statistical Methods and A... (389892), NIH | Genetic Analysis of Commo... (5R01GM031575-22), ARC | Statistical methods for d... (DP0879308), ARC | Statistical Methods for D... (DP1095849)

    Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understa...

  • publication . Article . 2011
    Open Access English
    Authors:
    Libo Wang; Vitara Pungpapong; Yanzhu Lin; Min Zhang; Dabao Zhang;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Early Cancer Detection &P... (5U01CA128535-04), NSF | CAREER: A New Regularizat... (0844945)

    Genome-wide association studies have successfully identified numerous loci at which common variants influence disease risks or quantitative traits of interest. Despite these successes, the variants identified by these studies have generally explained only a small fracti...

  • publication . Article . 2009
    Open Access English
    Authors:
    Park Yong-Moon; Province Michael A; Gao Xiaoyi; Feitosa Mary; Wu Jun; Ma Duanduan; Rao DC; Kraja Aldi T;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>We investigated the association of metabolic syndrome (MetS) with a 500 k and a 50 k single-nucleotide polymorphism (SNP) gene chip in the Framingham Heart Study. We cross-sectionally evaluated the MetS longitudinal trends. Data analyzed were from the...

  • publication . Article . 2016
    Open Access English
    Authors:
    Zhang, Dongni; Cui, Hongzhu; Korkin, Dmitry; Wu, Zheyang;
    Publisher: Springer Nature
    Project: NSF | MRI: Acquisition of a Hig... (1337943), WT , NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Statistical association studies are an important tool in detecting novel disease genes. However, for sequencing data, association studies confront the challenge of low power because of relatively small data sample size and rare variants. Incorporating biological informa...

449 research outcomes, page 3 of 45
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