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57,273 research outcomes, page 2 of 5,728
  • publication . Article . 2015
    Open Access English
    Authors:
    Carrara, M; Prischi, F; Nowak, P; Ali, M;
    Publisher: BlackWell Publishing Ltd
    Project: RCUK | Structural and mechanisti... (MR/L007436/1)

    Stress caused by accumulation of misfolded proteins within the endoplasmic reticulum (ER) elicits a cellular unfolded protein response (UPR) aimed at maintaining protein-folding capacity. PERK, a key upstream component, recognizes ER stress via its luminal sensor/transd...

  • publication . Preprint . Research . 2019
    Open Access English
    Authors:
    Pollington, TM; Tildesley, MJ; Hollingsworth, TD; Chapman, LAC;
    Project: RCUK | EPSRC and MRC Centre for ... (EP/L015374/1)

    Comment: Corresponding author is Timothy M. Pollington. Equal contributions by T. D\'eirdre Hollingsworth and Lloyd A. C. Chapman. 42 pgs, 7866 words, 1 fig., 1 table. Right-to-reply date added, refs' DoI links shortened

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Md Shaifur Rahman;
    Project: RCUK | Acellular Approaches for ... (MR/K026682/1)

    Background Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSCs that circumvent these aging-associated drawbacks...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Jubb, Harry; Blundell, Tom L.; Ascher, David B.;
    Publisher: Pergamon Press
    Project: RCUK | Understanding and Modulat... (BB/J500574/1), WT , NHMRC | Development of small mole... (1072476)

    The transient assembly of multiprotein complexes mediates many aspects of cell regulation and signalling in living organisms. Modulation of the formation of these complexes through targeting protein–protein interfaces can offer greater selectivity than the inhibition of...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Gregson, John; Kaptoge, Stephen; Bolton, Thomas; Pennells, Lisa; Willeit, Peter; Burgess, Stephen; Bell, Steven; Sweeting, Michael; Rimm, Eric B; Kabrhel, Christopher; ...
    Project: EC | EPICHEART (268834), EC | EPIC-CVD (279233), RCUK | Study of the interplay of... (G0800270)

    Key Points Question To what extent are established cardiovascular risk factors associated with risk of venous thromboembolism (VTE)? Findings In this analysis of individual participant data from the Emerging Risk Factors Collaboration and the UK Biobank including 1.1 mi...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Clark, Michael B.; Wrzesinski, Tomasz; Garcia, Aintzane B.; Hall, Nicola A. L.; Kleinman, Joel E.; Hyde, Thomas; Weinberger, Daniel R.; Harrison, Paul J.; Haerty, Wilfried; Tunbridge, Elizabeth M.;
    Publisher: Springer Science and Business Media LLC
    Project: NHMRC | Discovery and characteris... (1072662), WT | Capture NanoporeSeq: A no... (201879), RCUK | Brain-enriched voltage-ga... (MR/P026028/1)

    <jats:title>Abstract</jats:title><jats:p>RNA splicing is a key mechanism linking genetic variation with psychiatric disorders. Splicing profiles are particularly diverse in brain and difficult to accurately identify and quantify. We developed a new approach to address t...

  • publication . Article . 2014
    Open Access
    Authors:
    Bullen, A.; Taylor, R.R.; Kachar, B.; Moores, C.; Fleck, R.A.; Forge, A.;
    Publisher: Elsevier BV
    Project: RCUK | Structural organisations ... (BB/I02123X/1)

    In the preservation of tissues in as ‘close to life’ state as possible, rapid freeze fixation has many benefits over conventional chemical fixation. One technique by which rapid freeze-fixation can be achieved, high pressure freezing (HPF), has been shown to enable ice ...

  • publication . Article . 2017
    Open Access
    Authors:
    Roberts, GC; Zothner, C; Remenyi, R; Merits, A; Stonehouse, NJ; Harris, M;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | The Molecular Biology of ... (BB/K003801/1)

    Abstract Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread across the globe and as far north as southern Europe. There is currently no vaccine or anti-viral treatment available. Although there has been a recent increase in CHIKV re...

  • publication . Article . 2013
    Open Access
    Authors:
    Marsden, Alexander J.; Asensio, Maria-Carmen; Avila, José; Dudin, Pavel; Barinov, Alexei; Moras, Paolo; Sheverdyaeva, Polina M.; White, T. W.; Maskery, Ian; Costantini, Giovanni; ...
    Publisher: Wiley
    Project: RCUK | Warwick Centre for Analyt... (EP/F034210/1)

    Angle-resolved photoemission spectroscopy (ARPES) and X-ray photoemission spectroscopy have been used to characterise epitaxially ordered graphene grown on copper foil by low-pressure chemical vapour deposition. A short vacuum anneal to 200 °C allows observation of orde...

  • publication . Article . 2014
    Open Access
    Authors:
    Holly L. Baines; James B. Stewart; Craig Stamp; Anze Zupanic; Thomas B.L. Kirkwood; Nils-Göran Larsson; Douglass M. Turnbull; Laura C. Greaves;
    Project: RCUK | University of Newcastle C... (G0700718), WT | Mitochondrial DNA - expre... (096919), RCUK | Systems biology approach ... (BB/H011471/1), RCUK | Doctoral Training Grant (BB/F016980/1)

    Highlights • Colonic crypts with mitochondrial dysfunction accumulate with age in PolgA+/mut mice. • Mitochondrial dysfunction is caused by clonally expanded mtDNA point mutations. • The mutations are random and their expansion is not subject to selective constraints. •...

57,273 research outcomes, page 2 of 5,728
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