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22 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Tasos Gogakos; Tasos Gogakos; J. Fraser Glickman; Antonio Luz; Antonio Luz; Thomas Tuschl; Thomas Tuschl; Jessica Vincent; Rei Okamoto; Jumpei Aida; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Chemistry Biology Interfa... (4T32GM065086-14), NIH | Deciphering Post-transcri... (1R35GM119569-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Posttranscriptional regul... (5R01GM104962-02)

    Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS cr...

  • publication . Article . 2017
    Open Access English
    Authors:
    Yehuda Goldgur; Barbara S. Remus; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2018
    Open Access English
    Authors:
    Banerjee, Ankan; Ghosh, Shreya; Goldgur, Yehuda; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2019
    Open Access English
    Authors:
    Ankan Banerjee; Annum Munir; Leonora Abdullahu; Masad J. Damha; Yehuda Goldgur; Stewart Shuman;
    Publisher: Nature Publishing Group
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | New frontiers in extracel... (1R35GM122575-01)

    Tpt1 catalyzes the final essential step in yeast tRNA splicing and is a potential antifungal target. Here the authors provide structural insights into how Tpt1 recognizes a 2’-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation.

  • publication . Article . 2017
    Open Access
    Authors:
    Wenfu Ma; Elena Goldberg; Jonathan Goldberg; Jonathan Goldberg;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03)

    Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostas...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Frederick C. Streich; Christopher D. Lima; Christopher D. Lima;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    Summary Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear an...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Michael G. Kharas; Fraser Glickman; Gerard Minuesa; Sun Mi Park; Carolina Adura; Saroj Gourkanti; Levi N. Naden; Christina S. Leslie; Steven K. Albanese; Wei Xie; ...
    Publisher: Nature Publishing Group
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing MSI2 in le... (5R01CA193842-02)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Zhong Deng; Hongda Huang; Paul M. Lieberman; Fang Lu; Andreas Wiedmer; Dinshaw J. Patel; Olga Vladimirova;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | CONSOLIDATED BASIC CANCER... (5P30CA010815-28), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Chromatin Regulation of K... (1P01CA174439-01A1)

    The histone H3.3 chaperone DAXX is implicated in formation of heterochromatin and transcription silencing, especially for newly infecting DNA virus genomes entering the nucleus. Epstein-Barr virus (EBV) can efficiently establish stable latent infection as a chromatinize...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Dinshaw J. Patel; Jennifer Gebetsberger; Aiming Ren; Aiming Ren; Michael Andreas Juen; Christoph Kreutz; Ronald Micura; Nikola Vušurović; Pu Gao;
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | Biochemical and structura... (5U19CA179564-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), FWF | Single-molecule FRET inve... (I 1040), FWF | Seeing the invisible &#x9... (P 28725), SNSF | Exploring the function an... (P2BEP3_162061), FWF | Resolving excited states ... (P 26550), NIH | MOUSE GENETICS (2P30CA008748-43)

    The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architect...

  • publication . Article . 2018
    Open Access English
    Authors:
    Garg, Angad; Goldgur, Yehuda; Schwer, Beate; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | mRNA Capping Enzyme (2R01GM052470-09), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Pho7, a member of the Zn2Cys6 family of fungal transcription factors, is the key transcriptional activator underlying fission yeast phosphate homeostasis, a physiological response to phosphate starvation in which the pho1, pho84 and tgp1 genes are upregulated. ...

22 research outcomes, page 1 of 3