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6 research outcomes, page 1 of 1
  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Scott A. Armstrong; Scott A. Armstrong; Eric Still; Richard Koche; Alex Kentsis; Alex Kentsis; Anton G. Henssen; Anton G. Henssen; Elias Rodriguez-Fos; Ian C. MacArthur; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT

    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly...

  • publication . Preprint . 2016
    Open Access
    Authors:
    Kristina M. Knapp; Alex Kentsis; Esther Drill; Dean Pavlick; Steven M. Kornblau; Shan Zhong; Mithat Gönen; Ross L. Levine; Fiona C. Brown; Todd A. Alonzo; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Children's Oncology Group... (5U10CA180899-04), NIH | MOUSE GENETICS (2P30CA008748-43)

    <jats:title>Abstract</jats:title><jats:p>Despite intense efforts, the cure rates of children and adults with AML remain unsatisfactory in large part due to resistance to chemotherapy. Whilst cytogenetic risk stratification proved valuable in identifying causes of therap...

  • publication . Preprint . Other literature type . Article . 2015
    Open Access English
    Authors:
    Anton G. Henssen; Cédric Feschotte; Alex Kentsis; Melissa Burns; Christopher E. Mason; Jorge Gandara; Eric Still; Eileen Jiang; Mondira Ray; Amy Eisenberg; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02)

    eLife digest Transposons are mobile genetic elements that can be cut out of and inserted into DNA. They are present in most living things and make up almost half of the human genome. Transposons help to rearrange and increase the variety of DNA sequences, which can driv...

  • publication . Preprint . Other literature type . Article . 2016
    Open Access
    Authors:
    Anton G. Henssen; Alex Kentsis; Alex Kentsis; Daniel E. Bauer; Mithat Gönen; Scott A. Armstrong; Scott A. Armstrong; Luca Pinello; Eileen Jiang; Richard Koche; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Discovering disease-causa... (5K99HG008399-02), NIH | Epigenetic regulation of ... (4K08DK093705-05)

    <jats:title>Abstract</jats:title><jats:p><jats:bold>Background.</jats:bold> Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities o...

  • publication . Conference object . Preprint . 2017
    Open Access
    Authors:
    Casie Reed; Elizabeth Mullen; Scott A. Armstrong; Cristina R. Antonescu; Zhiping Weng; Stephen P. Jackson; Andrew N. Blackford; Richard Koche; Alex Kentsis; Catherine Reeves; ...
    Publisher: Georg Thieme Verlag KG
    Project: NIH | Administrative Core (5P50CA140146-04), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Clinical and Translationa... (3UL1TR000457-08S1), WT , NIH | MSKCC Pilot Center for Pr... (5U54OD020355-04)

    <jats:title>Abstract</jats:title><jats:p>Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the <jats:italic>piggyBac transposable element derived 5</jats:italic> (<jats:italic>PGBD5</...

  • publication . Article . 2017
    Open Access
    Authors:
    Sagar Chhangawala; Alex Kentsis; Alex Kentsis; Mojdeh Shakiba; Paolo Cifani;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Phosphoproteomic signatur... (5R21CA188881-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Aberrant activation of HG... (5K08CA160660-02), NIH | Aberrant signaling in acu... (5R01CA204396-03)

    Background High-accuracy mass spectrometry enables near comprehensive quantification of the components of the cellular proteomes, increasingly including their chemically modified variants. Likewise, large-scale libraries of quantified synthetic peptides are becoming ava...

6 research outcomes, page 1 of 1